FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896746272> ?p ?o ?g. }

• W2896746272 abstract "Hepatitis C virus (HCV) infection has reached epidemic proportions worldwide. Individuals with chronic HCV infection and without access to treatment are at high risk for developing hepatocellular carcinoma (HCC), a liver cancer that is rapidly fatal after diagnosis. A number of factors have been identified that contribute to HCV-driven carcinogenesis such as scarring of the liver, and chronic inflammation. Recent evidence indicates a direct role for HCV-encoded proteins themselves in oncogenesis of infected hepatocytes. The viral protein HCV core has been shown to interact directly with the host tumor suppressor protein p53, and to modulate p53-activity in a biphasic manner. Here, biochemically-motivated mathematical models of HCV-p53 interactions are developed to elucidate the mechanisms underlying this phenomenon. We show that by itself, direct interaction between HCV core and p53 is insufficient to recapitulate the experimental data. We postulate the existence of an additional factor, activated by HCV core that inhibits p53 function. We present experimental evidence in support of this hypothesis. The model including this additional factor reproduces the experimental results, validating our assumptions. Finally, we investigate what effect HCV core-p53 interactions could have on the capacity of an infected hepatocyte to repair damage to its DNA. Integrating our model with an existing model of the oscillatory response of p53 to DNA damage predicts a biphasic relationship between HCV core and the transformative potential of infected hepatocytes. In addition to providing mechanistic insights, these results suggest a potential biomarker that could help in identifying those HCV patients most at risk of progression to HCC." @default.
• W2896746272 created "2018-10-26" @default.
• W2896746272 creator A5058427076 @default.
• W2896746272 creator A5060684913 @default.
• W2896746272 creator A5063945429 @default.
• W2896746272 date "2018-12-01" @default.
• W2896746272 modified "2023-09-29" @default.
• W2896746272 title "Modeling hepatitis C virus protein and p53 interactions in hepatocytes: Implications for carcinogenesis" @default.
• W2896746272 cites W1561524145 @default.
• W2896746272 cites W1979634817 @default.
• W2896746272 cites W1987941191 @default.
• W2896746272 cites W1992629803 @default.
• W2896746272 cites W1996826591 @default.
• W2896746272 cites W1997268973 @default.
• W2896746272 cites W2008626862 @default.
• W2896746272 cites W2009071546 @default.
• W2896746272 cites W2015816582 @default.
• W2896746272 cites W2026273737 @default.
• W2896746272 cites W2028056951 @default.
• W2896746272 cites W2031183821 @default.
• W2896746272 cites W2037086486 @default.
• W2896746272 cites W2038487518 @default.
• W2896746272 cites W2042158802 @default.
• W2896746272 cites W2053978445 @default.
• W2896746272 cites W2056373849 @default.
• W2896746272 cites W2064883199 @default.
• W2896746272 cites W2065068903 @default.
• W2896746272 cites W2075157427 @default.
• W2896746272 cites W2079229783 @default.
• W2896746272 cites W2092658747 @default.
• W2896746272 cites W2097651998 @default.
• W2896746272 cites W2126209362 @default.
• W2896746272 cites W2141997480 @default.
• W2896746272 cites W2152750766 @default.
• W2896746272 cites W2156882828 @default.
• W2896746272 cites W2160411521 @default.
• W2896746272 cites W2161680561 @default.
• W2896746272 cites W2179429273 @default.
• W2896746272 cites W2213448039 @default.
• W2896746272 cites W2276496337 @default.
• W2896746272 cites W2344591610 @default.
• W2896746272 cites W2419462920 @default.
• W2896746272 cites W2467713285 @default.
• W2896746272 cites W2534504284 @default.
• W2896746272 cites W2606885999 @default.
• W2896746272 cites W2609960515 @default.
• W2896746272 cites W2738933006 @default.
• W2896746272 cites W2781452308 @default.
• W2896746272 cites W2792584735 @default.
• W2896746272 cites W4253306473 @default.
• W2896746272 doi "https://doi.org/10.1016/j.mbs.2018.10.003" @default.
• W2896746272 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30312632" @default.
• W2896746272 hasPublicationYear "2018" @default.
• W2896746272 type Work @default.
• W2896746272 sameAs 2896746272 @default.
• W2896746272 citedByCount "2" @default.
• W2896746272 countsByYear W28967462722020 @default.
• W2896746272 countsByYear W28967462722023 @default.
• W2896746272 crossrefType "journal-article" @default.
• W2896746272 hasAuthorship W2896746272A5058427076 @default.
• W2896746272 hasAuthorship W2896746272A5060684913 @default.
• W2896746272 hasAuthorship W2896746272A5063945429 @default.
• W2896746272 hasConcept C121608353 @default.
• W2896746272 hasConcept C143425029 @default.
• W2896746272 hasConcept C179185449 @default.
• W2896746272 hasConcept C202751555 @default.
• W2896746272 hasConcept C203014093 @default.
• W2896746272 hasConcept C2522874641 @default.
• W2896746272 hasConcept C2776200302 @default.
• W2896746272 hasConcept C2776231280 @default.
• W2896746272 hasConcept C2776408679 @default.
• W2896746272 hasConcept C2776455275 @default.
• W2896746272 hasConcept C2778019345 @default.
• W2896746272 hasConcept C2781197716 @default.
• W2896746272 hasConcept C502942594 @default.
• W2896746272 hasConcept C54355233 @default.
• W2896746272 hasConcept C552990157 @default.
• W2896746272 hasConcept C555283112 @default.
• W2896746272 hasConcept C86803240 @default.
• W2896746272 hasConceptScore W2896746272C121608353 @default.
• W2896746272 hasConceptScore W2896746272C143425029 @default.
• W2896746272 hasConceptScore W2896746272C179185449 @default.
• W2896746272 hasConceptScore W2896746272C202751555 @default.
• W2896746272 hasConceptScore W2896746272C203014093 @default.
• W2896746272 hasConceptScore W2896746272C2522874641 @default.
• W2896746272 hasConceptScore W2896746272C2776200302 @default.
• W2896746272 hasConceptScore W2896746272C2776231280 @default.
• W2896746272 hasConceptScore W2896746272C2776408679 @default.
• W2896746272 hasConceptScore W2896746272C2776455275 @default.
• W2896746272 hasConceptScore W2896746272C2778019345 @default.
• W2896746272 hasConceptScore W2896746272C2781197716 @default.
• W2896746272 hasConceptScore W2896746272C502942594 @default.
• W2896746272 hasConceptScore W2896746272C54355233 @default.
• W2896746272 hasConceptScore W2896746272C552990157 @default.
• W2896746272 hasConceptScore W2896746272C555283112 @default.
• W2896746272 hasConceptScore W2896746272C86803240 @default.
• W2896746272 hasLocation W28967462721 @default.
• W2896746272 hasLocation W28967462722 @default.
• W2896746272 hasOpenAccess W2896746272 @default.
• W2896746272 hasPrimaryLocation W28967462721 @default.

• next