Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896747973> ?p ?o ?g. }
- W2896747973 endingPage "1510" @default.
- W2896747973 startingPage "1503" @default.
- W2896747973 abstract "The recent spread of Zika virus stimulated extensive research on its structure, pathogenesis, and immunology, but mechanistic study of entry has lagged behind, in part due to the lack of a defined reconstituted system. Here, we report Zika membrane fusion measured using a platform that bypasses these barriers, enabling observation of single-virus fusion kinetics without receptor reconstitution. Surprisingly, target membrane binding and low pH are sufficient to trigger viral hemifusion to liposomes containing only neutral lipids. Second, although the extent of hemifusion strongly depends on pH, hemifusion rates are relatively insensitive to pH. Kinetic analysis shows that an off-pathway state is required to capture this pH-dependence and suggests this may be related to viral inactivation. Our surrogate-receptor approach thus yields new understanding of flaviviral entry mechanisms and should be applicable to many emerging viruses." @default.
- W2896747973 created "2018-10-26" @default.
- W2896747973 creator A5007451401 @default.
- W2896747973 creator A5016243291 @default.
- W2896747973 creator A5024261268 @default.
- W2896747973 creator A5065282202 @default.
- W2896747973 creator A5081016259 @default.
- W2896747973 date "2018-10-12" @default.
- W2896747973 modified "2023-10-02" @default.
- W2896747973 title "pH Dependence of Zika Membrane Fusion Kinetics Reveals an Off-Pathway State" @default.
- W2896747973 cites W1599389506 @default.
- W2896747973 cites W1857453373 @default.
- W2896747973 cites W1988313572 @default.
- W2896747973 cites W1992671025 @default.
- W2896747973 cites W1995505267 @default.
- W2896747973 cites W2003925822 @default.
- W2896747973 cites W2016266684 @default.
- W2896747973 cites W2019193901 @default.
- W2896747973 cites W2048172399 @default.
- W2896747973 cites W2048172776 @default.
- W2896747973 cites W2052975546 @default.
- W2896747973 cites W2058972016 @default.
- W2896747973 cites W2066383202 @default.
- W2896747973 cites W2068307678 @default.
- W2896747973 cites W2073049582 @default.
- W2896747973 cites W2087604412 @default.
- W2896747973 cites W2099051954 @default.
- W2896747973 cites W2104428288 @default.
- W2896747973 cites W2108412465 @default.
- W2896747973 cites W2109909805 @default.
- W2896747973 cites W2113093504 @default.
- W2896747973 cites W2122121966 @default.
- W2896747973 cites W2124402308 @default.
- W2896747973 cites W2124454170 @default.
- W2896747973 cites W2124547357 @default.
- W2896747973 cites W2127951618 @default.
- W2896747973 cites W2137159492 @default.
- W2896747973 cites W2138033073 @default.
- W2896747973 cites W2142445664 @default.
- W2896747973 cites W2143312809 @default.
- W2896747973 cites W2143467723 @default.
- W2896747973 cites W2147238119 @default.
- W2896747973 cites W2148263779 @default.
- W2896747973 cites W2171164919 @default.
- W2896747973 cites W2288648350 @default.
- W2896747973 cites W2316180691 @default.
- W2896747973 cites W2327138095 @default.
- W2896747973 cites W2460179838 @default.
- W2896747973 cites W2469610470 @default.
- W2896747973 cites W2470285990 @default.
- W2896747973 cites W2514945204 @default.
- W2896747973 cites W2533102129 @default.
- W2896747973 cites W2546845633 @default.
- W2896747973 cites W2552383104 @default.
- W2896747973 cites W2561350332 @default.
- W2896747973 cites W2586343602 @default.
- W2896747973 cites W2736051115 @default.
- W2896747973 cites W2755048196 @default.
- W2896747973 cites W2774432119 @default.
- W2896747973 cites W2792939613 @default.
- W2896747973 cites W4255375128 @default.
- W2896747973 doi "https://doi.org/10.1021/acscentsci.8b00494" @default.
- W2896747973 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6276045" @default.
- W2896747973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30555902" @default.
- W2896747973 hasPublicationYear "2018" @default.
- W2896747973 type Work @default.
- W2896747973 sameAs 2896747973 @default.
- W2896747973 citedByCount "41" @default.
- W2896747973 countsByYear W28967479732018 @default.
- W2896747973 countsByYear W28967479732019 @default.
- W2896747973 countsByYear W28967479732020 @default.
- W2896747973 countsByYear W28967479732021 @default.
- W2896747973 countsByYear W28967479732022 @default.
- W2896747973 countsByYear W28967479732023 @default.
- W2896747973 crossrefType "journal-article" @default.
- W2896747973 hasAuthorship W2896747973A5007451401 @default.
- W2896747973 hasAuthorship W2896747973A5016243291 @default.
- W2896747973 hasAuthorship W2896747973A5024261268 @default.
- W2896747973 hasAuthorship W2896747973A5065282202 @default.
- W2896747973 hasAuthorship W2896747973A5081016259 @default.
- W2896747973 hasBestOaLocation W28967479731 @default.
- W2896747973 hasConcept C103038307 @default.
- W2896747973 hasConcept C121332964 @default.
- W2896747973 hasConcept C12554922 @default.
- W2896747973 hasConcept C138885662 @default.
- W2896747973 hasConcept C140704245 @default.
- W2896747973 hasConcept C148898269 @default.
- W2896747973 hasConcept C152900378 @default.
- W2896747973 hasConcept C158525013 @default.
- W2896747973 hasConcept C159047783 @default.
- W2896747973 hasConcept C170493617 @default.
- W2896747973 hasConcept C185592680 @default.
- W2896747973 hasConcept C2522874641 @default.
- W2896747973 hasConcept C41625074 @default.
- W2896747973 hasConcept C41895202 @default.
- W2896747973 hasConcept C55493867 @default.
- W2896747973 hasConcept C58475186 @default.
- W2896747973 hasConcept C62520636 @default.