FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896750847> ?p ?o ?g. }

• W2896750847 endingPage "171" @default.
• W2896750847 startingPage "161" @default.
• W2896750847 abstract "Hibernating mammals use strong metabolic rate depression and a reduction in body temperature to near-ambient to survive the cold winter months. During torpor, protein synthesis is suppressed but can resume during interbout arousals. The current study aimed to identify molecular targets responsible for the global suppression of protein synthesis during torpor as well as possible mechanisms that could allow for selective protein translation to continue over this time. Relative changes in protein expression and/or phosphorylation levels of key translation factors (ribosomal protein S6, eIF4E, eIF2α, eEF2) and their upstream regulators (mTOR, TSC2, p70 S6K, 4EBP) were analyzed in liver and kidney of 13-lined ground squirrels (Ictidomys tridecemlineatus) sampled from six points over the torpor-arousal cycle. The results indicate that both organs reduce protein synthesis during torpor by decreasing mTOR and TSC2 phosphorylation between 30 and 70% of control levels. Translation resumes during interbout arousal when p-p70 S6K, p-rpS6, and p-4EBP levels returned to control values or above. Only liver translation factors were activated or disinhibited during periods of torpor itself, with >3-fold increases in total eIF2α and eEF2 protein levels, and a decrease in p-eEF2 (T56) to as low as 16% of the euthermic control value. These data shed light on a possible molecular mechanism involving eIF2α that could enable the translation of key transcripts during times of cell stress." @default.
• W2896750847 created "2018-10-26" @default.
• W2896750847 creator A5038766564 @default.
• W2896750847 creator A5063137585 @default.
• W2896750847 creator A5074785536 @default.
• W2896750847 date "2019-01-01" @default.
• W2896750847 modified "2023-09-27" @default.
• W2896750847 title "The squirrel with the lagging eIF2: Global suppression of protein synthesis during torpor" @default.
• W2896750847 cites W1500923019 @default.
• W2896750847 cites W1620917244 @default.
• W2896750847 cites W1870982485 @default.
• W2896750847 cites W1912491919 @default.
• W2896750847 cites W1969528211 @default.
• W2896750847 cites W1976200896 @default.
• W2896750847 cites W1976418244 @default.
• W2896750847 cites W1978227841 @default.
• W2896750847 cites W1985366099 @default.
• W2896750847 cites W1986235662 @default.
• W2896750847 cites W1987575348 @default.
• W2896750847 cites W1993722975 @default.
• W2896750847 cites W1994963220 @default.
• W2896750847 cites W1998682097 @default.
• W2896750847 cites W2006559495 @default.
• W2896750847 cites W2010217335 @default.
• W2896750847 cites W2011282245 @default.
• W2896750847 cites W2014597404 @default.
• W2896750847 cites W2016107719 @default.
• W2896750847 cites W2016169038 @default.
• W2896750847 cites W2024921031 @default.
• W2896750847 cites W2025562786 @default.
• W2896750847 cites W2026965565 @default.
• W2896750847 cites W2027552568 @default.
• W2896750847 cites W2037313242 @default.
• W2896750847 cites W2045830695 @default.
• W2896750847 cites W2059352954 @default.
• W2896750847 cites W2059451672 @default.
• W2896750847 cites W2088208585 @default.
• W2896750847 cites W2091572909 @default.
• W2896750847 cites W2092887892 @default.
• W2896750847 cites W2093393970 @default.
• W2896750847 cites W2101810211 @default.
• W2896750847 cites W2108456034 @default.
• W2896750847 cites W2110212291 @default.
• W2896750847 cites W2111514839 @default.
• W2896750847 cites W2122481289 @default.
• W2896750847 cites W2131639160 @default.
• W2896750847 cites W2136804822 @default.
• W2896750847 cites W2139424276 @default.
• W2896750847 cites W2144631239 @default.
• W2896750847 cites W2158627852 @default.
• W2896750847 cites W2159714906 @default.
• W2896750847 cites W2188772441 @default.
• W2896750847 cites W2219881886 @default.
• W2896750847 cites W2312282875 @default.
• W2896750847 cites W2323487000 @default.
• W2896750847 doi "https://doi.org/10.1016/j.cbpa.2018.10.014" @default.
• W2896750847 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30343059" @default.
• W2896750847 hasPublicationYear "2019" @default.
• W2896750847 type Work @default.
• W2896750847 sameAs 2896750847 @default.
• W2896750847 citedByCount "13" @default.
• W2896750847 countsByYear W28967508472020 @default.
• W2896750847 countsByYear W28967508472021 @default.
• W2896750847 countsByYear W28967508472022 @default.
• W2896750847 countsByYear W28967508472023 @default.
• W2896750847 crossrefType "journal-article" @default.
• W2896750847 hasAuthorship W2896750847A5038766564 @default.
• W2896750847 hasAuthorship W2896750847A5063137585 @default.
• W2896750847 hasAuthorship W2896750847A5074785536 @default.
• W2896750847 hasConcept C100564792 @default.
• W2896750847 hasConcept C104202773 @default.
• W2896750847 hasConcept C104317684 @default.
• W2896750847 hasConcept C105580179 @default.
• W2896750847 hasConcept C11413529 @default.
• W2896750847 hasConcept C11960822 @default.
• W2896750847 hasConcept C119865680 @default.
• W2896750847 hasConcept C126322002 @default.
• W2896750847 hasConcept C134018914 @default.
• W2896750847 hasConcept C149364088 @default.
• W2896750847 hasConcept C153911025 @default.
• W2896750847 hasConcept C161295673 @default.
• W2896750847 hasConcept C2780926556 @default.
• W2896750847 hasConcept C3675279 @default.
• W2896750847 hasConcept C39685955 @default.
• W2896750847 hasConcept C41008148 @default.
• W2896750847 hasConcept C48103436 @default.
• W2896750847 hasConcept C54355233 @default.
• W2896750847 hasConcept C62478195 @default.
• W2896750847 hasConcept C66538056 @default.
• W2896750847 hasConcept C71924100 @default.
• W2896750847 hasConcept C86554907 @default.
• W2896750847 hasConcept C86803240 @default.
• W2896750847 hasConcept C93734116 @default.
• W2896750847 hasConcept C95444343 @default.
• W2896750847 hasConcept C98490376 @default.
• W2896750847 hasConceptScore W2896750847C100564792 @default.
• W2896750847 hasConceptScore W2896750847C104202773 @default.
• W2896750847 hasConceptScore W2896750847C104317684 @default.

• next