FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W289675265> ?p ?o ?g. }

• W289675265 endingPage "20" @default.
• W289675265 startingPage "15" @default.
• W289675265 abstract "Fluoride ion, presumably an Al3+-F- complex, has been proposed to activate the guanine nucleotide regulatory protein (G-protein) of the visual system, transducin, by associating with GDP at the nucleotide-binding site and thus mimicking the effects of non-hydrolysable GTP analogues [Bigay, Deterre, Pfister & Chabre (1985) FEBS Lett. 191, 181-85]. We have examined this proposed model by using the adenylate cyclase complexes of frog erythrocytes, S49 lymphoma cells and human platelets. Preincubation of plasma membranes from frog erythrocytes and S49 cells with 20 mM-fluoride for 20 min at 30 degrees C strongly stimulated adenylate cyclase activity. In contrast, the preactivated membranes were still able to bind beta-adrenergic agonist with high affinity, as determined by radioligand-binding techniques. Moreover, high-affinity agonist binding in fluoride-treated membranes was fully sensitive to guanine nucleotide, which decreased beta-adrenergic-receptor affinity for agonist. Very similar results were obtained for [3H]prostaglandin E1 binding to S49 membranes pretreated with fluoride. Incubation of human platelet membranes with increasing concentrations of fluoride (1-50 mM) resulted in biphasic regulation of adenylate cyclase activity, with inhibition observed at concentrations greater than 10 mM. Preincubation of platelet membranes with 20 mM-fluoride did not affect agonist high-affinity binding to alpha 2-adrenergic receptors, nor receptor regulation by guanine nucleotide. These results suggest that the model developed from the study of transducin may not be generally applicable to the G-proteins of the adenylate cyclase system." @default.
• W289675265 created "2016-06-24" @default.
• W289675265 creator A5077755519 @default.
• W289675265 creator A5078695502 @default.
• W289675265 date "1988-08-15" @default.
• W289675265 modified "2023-09-25" @default.
• W289675265 title "Differential effects of fluoride on adenylate cyclase activity and guanine nucleotide regulation of agonist high-affinity receptor binding" @default.
• W289675265 cites W129838049 @default.
• W289675265 cites W1488907873 @default.
• W289675265 cites W1493609355 @default.
• W289675265 cites W1511887721 @default.
• W289675265 cites W1511914548 @default.
• W289675265 cites W1534116154 @default.
• W289675265 cites W1544256708 @default.
• W289675265 cites W1545247716 @default.
• W289675265 cites W1546511617 @default.
• W289675265 cites W1553946369 @default.
• W289675265 cites W1558437811 @default.
• W289675265 cites W1567061008 @default.
• W289675265 cites W1585952967 @default.
• W289675265 cites W1597332117 @default.
• W289675265 cites W1598028013 @default.
• W289675265 cites W1639941291 @default.
• W289675265 cites W1926371675 @default.
• W289675265 cites W1974855626 @default.
• W289675265 cites W1980068966 @default.
• W289675265 cites W1984080990 @default.
• W289675265 cites W1992742082 @default.
• W289675265 cites W2029328131 @default.
• W289675265 cites W2031750572 @default.
• W289675265 cites W2046753575 @default.
• W289675265 cites W2048378513 @default.
• W289675265 cites W2049337902 @default.
• W289675265 cites W2073121576 @default.
• W289675265 cites W2076118656 @default.
• W289675265 cites W2080875376 @default.
• W289675265 cites W2107465400 @default.
• W289675265 cites W2120640452 @default.
• W289675265 cites W2128635872 @default.
• W289675265 cites W2139129258 @default.
• W289675265 cites W2179950846 @default.
• W289675265 cites W224433986 @default.
• W289675265 cites W229759121 @default.
• W289675265 cites W2398877864 @default.
• W289675265 cites W2409804777 @default.
• W289675265 cites W2416237023 @default.
• W289675265 cites W2419580313 @default.
• W289675265 cites W4290473520 @default.
• W289675265 cites W72308821 @default.
• W289675265 doi "https://doi.org/10.1042/bj2540015" @default.
• W289675265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1135032" @default.
• W289675265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2845943" @default.
• W289675265 hasPublicationYear "1988" @default.
• W289675265 type Work @default.
• W289675265 sameAs 289675265 @default.
• W289675265 citedByCount "26" @default.
• W289675265 countsByYear W2896752652012 @default.
• W289675265 countsByYear W2896752652014 @default.
• W289675265 crossrefType "journal-article" @default.
• W289675265 hasAuthorship W289675265A5077755519 @default.
• W289675265 hasAuthorship W289675265A5078695502 @default.
• W289675265 hasBestOaLocation W2896752652 @default.
• W289675265 hasConcept C104317684 @default.
• W289675265 hasConcept C118716 @default.
• W289675265 hasConcept C12554922 @default.
• W289675265 hasConcept C170493617 @default.
• W289675265 hasConcept C180526460 @default.
• W289675265 hasConcept C181199279 @default.
• W289675265 hasConcept C185592680 @default.
• W289675265 hasConcept C2778301229 @default.
• W289675265 hasConcept C2778938600 @default.
• W289675265 hasConcept C2780069284 @default.
• W289675265 hasConcept C41625074 @default.
• W289675265 hasConcept C512185932 @default.
• W289675265 hasConcept C55493867 @default.
• W289675265 hasConcept C80631254 @default.
• W289675265 hasConcept C86803240 @default.
• W289675265 hasConceptScore W289675265C104317684 @default.
• W289675265 hasConceptScore W289675265C118716 @default.
• W289675265 hasConceptScore W289675265C12554922 @default.
• W289675265 hasConceptScore W289675265C170493617 @default.
• W289675265 hasConceptScore W289675265C180526460 @default.
• W289675265 hasConceptScore W289675265C181199279 @default.
• W289675265 hasConceptScore W289675265C185592680 @default.
• W289675265 hasConceptScore W289675265C2778301229 @default.
• W289675265 hasConceptScore W289675265C2778938600 @default.
• W289675265 hasConceptScore W289675265C2780069284 @default.
• W289675265 hasConceptScore W289675265C41625074 @default.
• W289675265 hasConceptScore W289675265C512185932 @default.
• W289675265 hasConceptScore W289675265C55493867 @default.
• W289675265 hasConceptScore W289675265C80631254 @default.
• W289675265 hasConceptScore W289675265C86803240 @default.
• W289675265 hasIssue "1" @default.
• W289675265 hasLocation W2896752651 @default.
• W289675265 hasLocation W2896752652 @default.
• W289675265 hasLocation W2896752653 @default.
• W289675265 hasLocation W2896752654 @default.
• W289675265 hasOpenAccess W289675265 @default.

• next