FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896760004> ?p ?o ?g. }

• W2896760004 endingPage "421" @default.
• W2896760004 startingPage "421" @default.
• W2896760004 abstract "Botulinum neurotoxins (BoNTs) are categorised into immunologically distinct serotypes BoNT/A to /G). Each serotype can also be further divided into subtypes based on differences in amino acid sequence. BoNTs are ~150 kDa proteins comprised of three major functional domains: an N-terminal zinc metalloprotease light chain (LC), a translocation domain (HN), and a binding domain (HC). The HC is responsible for targeting the BoNT to the neuronal cell membrane, and each serotype has evolved to bind via different mechanisms to different target receptors. Most structural characterisations to date have focussed on the first identified subtype within each serotype (e.g., BoNT/A1). Subtype differences within BoNT serotypes can affect intoxication, displaying different botulism symptoms in vivo, and less emphasis has been placed on investigating these variants. This review outlines the receptors for each BoNT serotype and describes the basis for the highly specific targeting of neuronal cell membranes. Understanding receptor binding is of vital importance, not only for the generation of novel therapeutics but also for understanding how best to protect from intoxication." @default.
• W2896760004 created "2018-10-26" @default.
• W2896760004 creator A5009694357 @default.
• W2896760004 creator A5042847807 @default.
• W2896760004 creator A5086966211 @default.
• W2896760004 date "2018-10-20" @default.
• W2896760004 modified "2023-09-26" @default.
• W2896760004 title "Variations in the Botulinum Neurotoxin Binding Domain and the Potential for Novel Therapeutics" @default.
• W2896760004 cites W1212061175 @default.
• W2896760004 cites W1512249026 @default.
• W2896760004 cites W1512697776 @default.
• W2896760004 cites W1569966670 @default.
• W2896760004 cites W1626933118 @default.
• W2896760004 cites W1688629966 @default.
• W2896760004 cites W1802770608 @default.
• W2896760004 cites W1831356709 @default.
• W2896760004 cites W1874976250 @default.
• W2896760004 cites W1964336064 @default.
• W2896760004 cites W1965556555 @default.
• W2896760004 cites W1969532190 @default.
• W2896760004 cites W1969789782 @default.
• W2896760004 cites W1977132430 @default.
• W2896760004 cites W1985297128 @default.
• W2896760004 cites W1986815482 @default.
• W2896760004 cites W1988075499 @default.
• W2896760004 cites W1990636181 @default.
• W2896760004 cites W1990770950 @default.
• W2896760004 cites W1992192055 @default.
• W2896760004 cites W1993581461 @default.
• W2896760004 cites W1995616760 @default.
• W2896760004 cites W1998156768 @default.
• W2896760004 cites W2000928010 @default.
• W2896760004 cites W2002090038 @default.
• W2896760004 cites W2003381605 @default.
• W2896760004 cites W2003626688 @default.
• W2896760004 cites W2005898230 @default.
• W2896760004 cites W2006583398 @default.
• W2896760004 cites W2007113735 @default.
• W2896760004 cites W2008146383 @default.
• W2896760004 cites W2009018979 @default.
• W2896760004 cites W2009698093 @default.
• W2896760004 cites W2011748656 @default.
• W2896760004 cites W2011949386 @default.
• W2896760004 cites W2017697138 @default.
• W2896760004 cites W2018321735 @default.
• W2896760004 cites W2021055218 @default.
• W2896760004 cites W2025609921 @default.
• W2896760004 cites W2025682195 @default.
• W2896760004 cites W2027690554 @default.
• W2896760004 cites W2027872729 @default.
• W2896760004 cites W2033701533 @default.
• W2896760004 cites W2035026956 @default.
• W2896760004 cites W2035545621 @default.
• W2896760004 cites W2036059965 @default.
• W2896760004 cites W2040007369 @default.
• W2896760004 cites W2041010702 @default.
• W2896760004 cites W2045544140 @default.
• W2896760004 cites W2048591784 @default.
• W2896760004 cites W2048927738 @default.
• W2896760004 cites W2050874350 @default.
• W2896760004 cites W2053492423 @default.
• W2896760004 cites W2053901147 @default.
• W2896760004 cites W2055630989 @default.
• W2896760004 cites W2056155828 @default.
• W2896760004 cites W2057554063 @default.
• W2896760004 cites W2058336470 @default.
• W2896760004 cites W2058845974 @default.
• W2896760004 cites W2060407338 @default.
• W2896760004 cites W2061704677 @default.
• W2896760004 cites W2063099628 @default.
• W2896760004 cites W2065909915 @default.
• W2896760004 cites W2066038385 @default.
• W2896760004 cites W2072108954 @default.
• W2896760004 cites W2073850595 @default.
• W2896760004 cites W2076386790 @default.
• W2896760004 cites W2078970687 @default.
• W2896760004 cites W2079728044 @default.
• W2896760004 cites W2082381961 @default.
• W2896760004 cites W2083277025 @default.
• W2896760004 cites W2084706576 @default.
• W2896760004 cites W2085752802 @default.
• W2896760004 cites W2089457319 @default.
• W2896760004 cites W2089899426 @default.
• W2896760004 cites W2090106870 @default.
• W2896760004 cites W2091460376 @default.
• W2896760004 cites W2093498483 @default.
• W2896760004 cites W2093558788 @default.
• W2896760004 cites W2096738649 @default.
• W2896760004 cites W2101211619 @default.
• W2896760004 cites W2107096504 @default.
• W2896760004 cites W2107653044 @default.
• W2896760004 cites W2122823722 @default.
• W2896760004 cites W2124576725 @default.
• W2896760004 cites W2126213235 @default.
• W2896760004 cites W2128833323 @default.
• W2896760004 cites W2130650278 @default.
• W2896760004 cites W2130853126 @default.
• W2896760004 cites W2132639205 @default.

• next