FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896760528> ?p ?o ?g. }

• W2896760528 abstract "Abstract We previously demonstrated that Cry j1, the major pollen allergen of Cryptomeria japonica (Japanese cedar), transiently increases protease activity and intracellular Ca 2+ concentration in cultured human keratinocytes, and delays recovery after stratum corneum barrier disruption in human skin ex vivo . Topical application of tranexamic acid or trypsin-type serine protease inhibitors accelerates barrier recovery. We hypothesized that tranexamic acid might prevent the transient protease activity increase and the barrier recovery delay induced by Cry j1. Here, we tested this hypothesis and examined the mechanism involved. In cultured human keratinocytes, knock-down of protease-activated receptor 1 (PAR-1) reduced the transient increase of calcium induced by Cry j1, whereas knock-down of PAR-2 did not. Knock-down of thrombin significantly reduced the transient increases of calcium concentration and protease activity. Tranexamic acid, soybean trypsin inhibitor, or bivalirudin (a thrombin inhibitor) also reduced the calcium elevation induced by Cry j1 and/or thrombin. Co-application of tranexamic acid or bivalirudin with Cry j1 to human skin ex vivo blocked the delay of barrier recovery. These results suggest that thrombin and PAR-1 or PAR-1-like receptor might mediate the adverse effects of Cry j1 on human epidermal keratinocytes, and could open up a new strategy for treating inflammatory skin diseases." @default.
• W2896760528 created "2018-10-26" @default.
• W2896760528 creator A5032755468 @default.
• W2896760528 creator A5052637025 @default.
• W2896760528 creator A5072318133 @default.
• W2896760528 date "2018-10-23" @default.
• W2896760528 modified "2023-10-11" @default.
• W2896760528 title "Tranexamic acid blocks the thrombin-mediated delay of epidermal permeability barrier recovery induced by the cedar pollen allergen, Cry j1" @default.
• W2896760528 cites W1479990836 @default.
• W2896760528 cites W1539126918 @default.
• W2896760528 cites W1559151919 @default.
• W2896760528 cites W1640160692 @default.
• W2896760528 cites W1796640198 @default.
• W2896760528 cites W1811402656 @default.
• W2896760528 cites W1979236963 @default.
• W2896760528 cites W1985737035 @default.
• W2896760528 cites W1990176006 @default.
• W2896760528 cites W1991202990 @default.
• W2896760528 cites W2012238881 @default.
• W2896760528 cites W2012761317 @default.
• W2896760528 cites W2020831130 @default.
• W2896760528 cites W2034643342 @default.
• W2896760528 cites W2038747404 @default.
• W2896760528 cites W2047515048 @default.
• W2896760528 cites W2050925937 @default.
• W2896760528 cites W2085319206 @default.
• W2896760528 cites W2091468884 @default.
• W2896760528 cites W2096778485 @default.
• W2896760528 cites W2098516009 @default.
• W2896760528 cites W2155552330 @default.
• W2896760528 cites W2159278900 @default.
• W2896760528 cites W2166170833 @default.
• W2896760528 cites W2173040607 @default.
• W2896760528 cites W2327790980 @default.
• W2896760528 cites W2330540452 @default.
• W2896760528 cites W2604215835 @default.
• W2896760528 cites W2622940266 @default.
• W2896760528 doi "https://doi.org/10.1038/s41598-018-33898-7" @default.
• W2896760528 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6199325" @default.
• W2896760528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30353092" @default.
• W2896760528 hasPublicationYear "2018" @default.
• W2896760528 type Work @default.
• W2896760528 sameAs 2896760528 @default.
• W2896760528 citedByCount "6" @default.
• W2896760528 countsByYear W28967605282020 @default.
• W2896760528 countsByYear W28967605282021 @default.
• W2896760528 countsByYear W28967605282023 @default.
• W2896760528 crossrefType "journal-article" @default.
• W2896760528 hasAuthorship W2896760528A5032755468 @default.
• W2896760528 hasAuthorship W2896760528A5052637025 @default.
• W2896760528 hasAuthorship W2896760528A5072318133 @default.
• W2896760528 hasBestOaLocation W28967605281 @default.
• W2896760528 hasConcept C141071460 @default.
• W2896760528 hasConcept C181199279 @default.
• W2896760528 hasConcept C185592680 @default.
• W2896760528 hasConcept C203014093 @default.
• W2896760528 hasConcept C2776714187 @default.
• W2896760528 hasConcept C2777292125 @default.
• W2896760528 hasConcept C2777807008 @default.
• W2896760528 hasConcept C2779637338 @default.
• W2896760528 hasConcept C2991743468 @default.
• W2896760528 hasConcept C55493867 @default.
• W2896760528 hasConcept C71924100 @default.
• W2896760528 hasConcept C86803240 @default.
• W2896760528 hasConcept C89560881 @default.
• W2896760528 hasConcept C98274493 @default.
• W2896760528 hasConceptScore W2896760528C141071460 @default.
• W2896760528 hasConceptScore W2896760528C181199279 @default.
• W2896760528 hasConceptScore W2896760528C185592680 @default.
• W2896760528 hasConceptScore W2896760528C203014093 @default.
• W2896760528 hasConceptScore W2896760528C2776714187 @default.
• W2896760528 hasConceptScore W2896760528C2777292125 @default.
• W2896760528 hasConceptScore W2896760528C2777807008 @default.
• W2896760528 hasConceptScore W2896760528C2779637338 @default.
• W2896760528 hasConceptScore W2896760528C2991743468 @default.
• W2896760528 hasConceptScore W2896760528C55493867 @default.
• W2896760528 hasConceptScore W2896760528C71924100 @default.
• W2896760528 hasConceptScore W2896760528C86803240 @default.
• W2896760528 hasConceptScore W2896760528C89560881 @default.
• W2896760528 hasConceptScore W2896760528C98274493 @default.
• W2896760528 hasIssue "1" @default.
• W2896760528 hasLocation W28967605281 @default.
• W2896760528 hasLocation W28967605282 @default.
• W2896760528 hasLocation W28967605283 @default.
• W2896760528 hasLocation W28967605284 @default.
• W2896760528 hasLocation W28967605285 @default.
• W2896760528 hasOpenAccess W2896760528 @default.
• W2896760528 hasPrimaryLocation W28967605281 @default.
• W2896760528 hasRelatedWork W2026960302 @default.
• W2896760528 hasRelatedWork W2034091109 @default.
• W2896760528 hasRelatedWork W2036951984 @default.
• W2896760528 hasRelatedWork W2054083197 @default.
• W2896760528 hasRelatedWork W2065840164 @default.
• W2896760528 hasRelatedWork W2107256410 @default.
• W2896760528 hasRelatedWork W2114609271 @default.
• W2896760528 hasRelatedWork W2139138166 @default.
• W2896760528 hasRelatedWork W2152016385 @default.
• W2896760528 hasRelatedWork W2189951998 @default.
• W2896760528 hasVolume "8" @default.
• W2896760528 isParatext "false" @default.

• next