FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896763251> ?p ?o ?g. }

• W2896763251 endingPage "19037" @default.
• W2896763251 startingPage "19025" @default.
• W2896763251 abstract "Blunted melanocortin 1 receptor (MC1R) signaling promotes melanocyte genomic instability in part by attenuating cAMP-mediated DNA repair responses, particularly nucleotide excision repair (NER), which recognizes and clears mutagenic photodamage. cAMP-enhanced NER is mediated by interactions between the ataxia telangiectasia-mutated and Rad3-related (ATR) and xeroderma pigmentosum complementation group A (XPA) proteins. We now report a critical role for sirtuin 1 (SIRT1) in regulating ATR-mediated phosphorylation of XPA. SIRT1 deacetylates XPA at residues Lys-63, Lys-67, and Lys-215 to promote interactions with ATR. Mutant XPA containing acetylation mimetics at residues Lys-63, Lys-67, and Lys-215 exhibit blunted UV-dependent ATR–XPA interactions even in the presence of cAMP signals. ATR-mediated phosphorylation of XPA on Ser-196 enhances cAMP-mediated optimization of NER and is promoted by SIRT1-mediated deacetylation of XPA on Lys-63, Lys-67, and Lys-215. Interference with ATR-mediated XPA phosphorylation at Ser-196 by persistent acetylation of XPA at Lys-63, Lys-67, and Lys-215 delays repair of UV-induced DNA damage and attenuates cAMP-enhanced NER. Our study identifies a regulatory ATR–SIRT1–XPA axis in cAMP-mediated regulation melanocyte genomic stability, involving SIRT1-mediated deacetylation (Lys-63, Lys-67, and Lys-215) and ATR-dependent phosphorylation (Ser-196) post-translational modifications of the core NER factor XPA. Blunted melanocortin 1 receptor (MC1R) signaling promotes melanocyte genomic instability in part by attenuating cAMP-mediated DNA repair responses, particularly nucleotide excision repair (NER), which recognizes and clears mutagenic photodamage. cAMP-enhanced NER is mediated by interactions between the ataxia telangiectasia-mutated and Rad3-related (ATR) and xeroderma pigmentosum complementation group A (XPA) proteins. We now report a critical role for sirtuin 1 (SIRT1) in regulating ATR-mediated phosphorylation of XPA. SIRT1 deacetylates XPA at residues Lys-63, Lys-67, and Lys-215 to promote interactions with ATR. Mutant XPA containing acetylation mimetics at residues Lys-63, Lys-67, and Lys-215 exhibit blunted UV-dependent ATR–XPA interactions even in the presence of cAMP signals. ATR-mediated phosphorylation of XPA on Ser-196 enhances cAMP-mediated optimization of NER and is promoted by SIRT1-mediated deacetylation of XPA on Lys-63, Lys-67, and Lys-215. Interference with ATR-mediated XPA phosphorylation at Ser-196 by persistent acetylation of XPA at Lys-63, Lys-67, and Lys-215 delays repair of UV-induced DNA damage and attenuates cAMP-enhanced NER. Our study identifies a regulatory ATR–SIRT1–XPA axis in cAMP-mediated regulation melanocyte genomic stability, involving SIRT1-mediated deacetylation (Lys-63, Lys-67, and Lys-215) and ATR-dependent phosphorylation (Ser-196) post-translational modifications of the core NER factor XPA. Withdrawal: Sirtuin 1-mediated deacetylation of XPA DNA repair protein enhances its interaction with ATR protein and promotes cAMP-induced DNA repair of UV damageJournal of Biological ChemistryVol. 296PreviewVOLUME 293 (2018) PAGES 19025–19037 Full-Text PDF Open AccessExpression of Concern: Sirtuin 1-mediated deacetylation of XPA DNA repair protein enhances its interaction with ATR protein and promotes cAMP-induced DNA repair of UV damage.Journal of Biological ChemistryVol. 295Issue 41PreviewVOLUME 293 (2018) PAGES 19025–19037 Full-Text PDF Open Access" @default.
• W2896763251 created "2018-10-26" @default.
• W2896763251 creator A5015978857 @default.
• W2896763251 creator A5018391981 @default.
• W2896763251 creator A5028221691 @default.
• W2896763251 creator A5052166954 @default.
• W2896763251 creator A5055207647 @default.
• W2896763251 creator A5078924265 @default.
• W2896763251 date "2018-12-01" @default.
• W2896763251 modified "2023-10-15" @default.
• W2896763251 title "Sirtuin 1-mediated deacetylation of XPA DNA repair protein enhances its interaction with ATR protein and promotes cAMP-induced DNA repair of UV damage" @default.
• W2896763251 cites W1607596288 @default.
• W2896763251 cites W1942110646 @default.
• W2896763251 cites W1967049460 @default.
• W2896763251 cites W1967630574 @default.
• W2896763251 cites W1968552183 @default.
• W2896763251 cites W1974022382 @default.
• W2896763251 cites W1979028355 @default.
• W2896763251 cites W1979580952 @default.
• W2896763251 cites W1981605211 @default.
• W2896763251 cites W1984093745 @default.
• W2896763251 cites W1994422535 @default.
• W2896763251 cites W1996393189 @default.
• W2896763251 cites W2005863107 @default.
• W2896763251 cites W2006809167 @default.
• W2896763251 cites W2022732422 @default.
• W2896763251 cites W2022811243 @default.
• W2896763251 cites W2025589989 @default.
• W2896763251 cites W2025654886 @default.
• W2896763251 cites W2029090108 @default.
• W2896763251 cites W2031707796 @default.
• W2896763251 cites W2034710079 @default.
• W2896763251 cites W2038144270 @default.
• W2896763251 cites W2038180878 @default.
• W2896763251 cites W2050293032 @default.
• W2896763251 cites W2056501544 @default.
• W2896763251 cites W2057834096 @default.
• W2896763251 cites W2067131659 @default.
• W2896763251 cites W2073667001 @default.
• W2896763251 cites W2074851554 @default.
• W2896763251 cites W2077289900 @default.
• W2896763251 cites W2083874142 @default.
• W2896763251 cites W2087177695 @default.
• W2896763251 cites W2096125037 @default.
• W2896763251 cites W2097124161 @default.
• W2896763251 cites W2103451229 @default.
• W2896763251 cites W2110817748 @default.
• W2896763251 cites W2112636438 @default.
• W2896763251 cites W2116594363 @default.
• W2896763251 cites W2118964113 @default.
• W2896763251 cites W2126666661 @default.
• W2896763251 cites W2133318290 @default.
• W2896763251 cites W2134471382 @default.
• W2896763251 cites W2137370771 @default.
• W2896763251 cites W2137855486 @default.
• W2896763251 cites W2138214273 @default.
• W2896763251 cites W2138759171 @default.
• W2896763251 cites W2149793889 @default.
• W2896763251 cites W2153466677 @default.
• W2896763251 cites W2162136322 @default.
• W2896763251 cites W2162249357 @default.
• W2896763251 cites W2269031989 @default.
• W2896763251 cites W2293228432 @default.
• W2896763251 cites W2400580371 @default.
• W2896763251 cites W2400984959 @default.
• W2896763251 cites W2474228978 @default.
• W2896763251 cites W2508979819 @default.
• W2896763251 cites W2525360026 @default.
• W2896763251 cites W2591944756 @default.
• W2896763251 cites W2593147816 @default.
• W2896763251 cites W2745330422 @default.
• W2896763251 cites W2753492878 @default.
• W2896763251 cites W2753570822 @default.
• W2896763251 cites W2755981740 @default.
• W2896763251 cites W2795713411 @default.
• W2896763251 cites W4211123988 @default.
• W2896763251 doi "https://doi.org/10.1074/jbc.ra118.003940" @default.
• W2896763251 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8027263" @default.
• W2896763251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34237903" @default.
• W2896763251 hasPublicationYear "2018" @default.
• W2896763251 type Work @default.
• W2896763251 sameAs 2896763251 @default.
• W2896763251 citedByCount "27" @default.
• W2896763251 countsByYear W28967632512019 @default.
• W2896763251 countsByYear W28967632512020 @default.
• W2896763251 countsByYear W28967632512021 @default.
• W2896763251 countsByYear W28967632512022 @default.
• W2896763251 countsByYear W28967632512023 @default.
• W2896763251 crossrefType "journal-article" @default.
• W2896763251 hasAuthorship W2896763251A5015978857 @default.
• W2896763251 hasAuthorship W2896763251A5018391981 @default.
• W2896763251 hasAuthorship W2896763251A5028221691 @default.
• W2896763251 hasAuthorship W2896763251A5052166954 @default.
• W2896763251 hasAuthorship W2896763251A5055207647 @default.
• W2896763251 hasAuthorship W2896763251A5078924265 @default.
• W2896763251 hasBestOaLocation W28967632511 @default.
• W2896763251 hasConcept C104317684 @default.
• W2896763251 hasConcept C104451858 @default.

• next