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- W2896763984 abstract "Syzygium cumini is a well known bioactive plant which has been widely used for thetreatment of various diseases in traditional and folk medicine. The present investigation wasaimed to determine the tocolytic activity of the aqueous seed extract of Syzygium cumini(AESC) in animal models. The in vitro antioxidant activity of AESC was evaluated by DPPHand ABTS radical scavenging assay which showed the hydrogen donating and free radicalscavenging activity of extract that aids in the prevention of preterm labour. In vivo tocolyticactivity of AESC was evaluated. Group I was given normal saline, Group II oxytocin (1 IU)i.m, Group III atosiban (6mg/kg) i.p, Group IV AESC (200mg/kg) p.o and Group V AESC(400mg/kg), p.o. AESC shows significant reduction in the rate of preterm labour which wascomparable with the standard treated group as well as the normal group. The level of in vivoantioxidant parameters such as catalase, SOD, and GSH were restored in the treated groupcompared to the control group. The study reveals that the extracts have been able to increasethe endogenous antioxidant enzyme activities while reducing the lipid peroxidation. TheAESC was subjected to pharmacological testing in vitro on a piece of isolated rat uteruspreviously pretreated with estradiol valerate, concentrations used were 25 mg/ml and 50mg/ml. The concentrations (25 mg/ml) and (50 mg/ml) produce 50.9 % and 72.7 % inhibitionrespectively. In conclusion, the results indicate the presence of active principles in theaqueous seed extract of Syzygium cumini which may be responsible for the tocolytic activity." @default.
- W2896763984 created "2018-10-26" @default.
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- W2896763984 date "2017-10-01" @default.
- W2896763984 modified "2023-09-27" @default.
- W2896763984 title "Evaluation of Tocolytic Activity of Aqueous Seed Extract of Syzygium Cumini on Oxytocin Induced Preterm Labour" @default.
- W2896763984 hasPublicationYear "2017" @default.
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