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- W2896765746 endingPage "34934" @default.
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- W2896765746 abstract "Survivin, a member of the inhibitor of apoptosis (IAP) protein family plays a significant role in cell fate and function. It is significantly overexpressed in tumor cells and has been identified in most cancer cell types. A novel extracellular population has recently been identified and its function is still unknown. Emerging evidence continues to shed light on the important role the tumor microenvironment (TME) has on tumor survival and progression. This new population of survivin has been seen to enhance the tumor phenotype when internalized by recipient cells. In this paper, we sought to better understand the mechanism by which survivin is taken up by cancer cells and the possible role it plays in this phenomenon. We isolated the exosomal carriers of extracellular survivin and using a lipophilic stain, PKH67, we tracked their uptake with immunofluorescence and flow cytometry. We found that by blocking exosomal survivin, exosome internalization is reduced, signifying a novel function for this protein. We also discovered that the common membrane receptors, transferrin receptor, endothelin B receptor, insulin receptor alpha, and membrane glucocorticoid receptor all facilitate exosomal internalization. This understanding further clarifies the protein-protein interactions in the TME that may influence tumor progression and identifies additional potential chemotherapeutic targets." @default.
- W2896765746 created "2018-10-26" @default.
- W2896765746 creator A5007503726 @default.
- W2896765746 creator A5011944787 @default.
- W2896765746 creator A5024398126 @default.
- W2896765746 creator A5040623212 @default.
- W2896765746 creator A5046343435 @default.
- W2896765746 creator A5049604142 @default.
- W2896765746 creator A5063547685 @default.
- W2896765746 date "2018-10-09" @default.
- W2896765746 modified "2023-10-01" @default.
- W2896765746 title "Exosomal survivin facilitates vesicle internalization" @default.
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