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• W2896766743 abstract "Herein, we report the discovery of a novel potent, selective, CNS penetrant, and orally bioavailable mGlu4 PAM, VU0652957 (VU2957, Valiglurax). VU2957 possessed attractive in vitro and in vivo pharmacological and DMPK properties across species. To advance toward the clinic, a spray-dried dispersion (SDD) formulation of VU2957 was developed to support IND-enabling toxicology studies. Based on its overall profile, VU2957 was evaluated as a preclinical development candidate for the treatment of Parkinson's disease." @default.
• W2896766743 created "2018-10-26" @default.
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• W2896766743 date "2018-10-16" @default.
• W2896766743 modified "2023-10-04" @default.
• W2896766743 title "Discovery of VU2957 (Valiglurax): An mGlu₄ Positive Allosteric Modulator Evaluated as a Preclinical Candidate for the Treatment of Parkinson’s Disease" @default.
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• W2896766743 doi "https://doi.org/10.1021/acsmedchemlett.8b00426" @default.
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