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• W2896768440 abstract "In the past 2 decades, metastasis-associated gene 1 (MTA1) has attracted attention for its close association with cancer progression and its roles in chromatin remodeling processes, making it a central gene in cancer. The present meta-analysis was performed to assess MTA1 expression in solid tumors.This analysis identified studies that evaluated the relationship between MTA1 expression and clinical characteristics or prognosis of patients with solid tumors via the PubMed, Cochrane Library, and Embase electronic databases. Fixed-effect and random-effect meta-analytical techniques were used to correlate MTA1 expression with outcome measures. The outcome variables are shown as odds ratio (OR) or hazard ratio (HR) with 95% confidence interval (CI).Analysis of 40 cohort studies involving 4564 cancer patients revealed a significant association of MTA1 overexpression with tumor patient age (>50 vs. <50 years: combined OR 0.73, 95% CI 0.57-0.94), tumor grade (G3/4 vs. G1/2: combined OR 1.94, 95% CI 1.48-2.53), tumor size (>3 cm vs. <3 cm: combined OR 2.35, 95% CI 1.73-3.19), T stage (T3/4 vs. T1/2: combined OR 2.11, 95% CI 1.74-2.56), lymph node metastasis (yes vs. no: combined OR 2.92, 95% CI 2.26-3.75), distant metastasis (yes vs. no: combined OR 2.26, 95% CI 1.42-3.59), TNM stage (III/IV vs. I/II: combined OR 2.50, 95% CI 1.84-3.38), vascular invasion (yes vs. no: combined OR 2.26, 95% CI 1.92-3.56), and poor overall survival time (HR 1.83; 95% CI: 1.53-2.20; P = .000).Our analyses demonstrate that MTA1 was an effective predictor of a worse prognosis in tumor patients. Moreover, MTA1 may play important role in tumor progression and outcome, and targeting MTA1 may be a new strategy for anti-cancer therapy." @default.
• W2896768440 created "2018-10-26" @default.
• W2896768440 creator A5001601148 @default.
• W2896768440 creator A5024334309 @default.
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• W2896768440 date "2018-10-01" @default.
• W2896768440 modified "2023-09-25" @default.
• W2896768440 title "Prognostic and clinical significance of metastasis-associated gene 1 overexpression in solid cancers" @default.
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• W2896768440 doi "https://doi.org/10.1097/md.0000000000012292" @default.
• W2896768440 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6203568" @default.
• W2896768440 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30313027" @default.
• W2896768440 hasPublicationYear "2018" @default.
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