FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896770837> ?p ?o ?g. }

• W2896770837 endingPage "17" @default.
• W2896770837 startingPage "10" @default.
• W2896770837 abstract "Intervertebral disc (IVD) degeneration has a complex multifactorial origin and it is tightly associated with changes in the secretion of proteoglycans and collagen of the Nucleus Pulposus (NP) extracellular matrix. Chronic infection by Herpes virus has been previously associated with disc degeneration after detection of Herpes Simplex Virus type-1 (HSV-1) and CMV DNA in human excised disc samples. The aim of the present study was to assess the effect of HSV-1 infection on proteoglycan synthesis employing human Nucleus Pulposus (HNPCs) cells as a model of intervertebral disc degeneration. During lytic HSV-1 infection, a significant reduction of Decorin expression was observed 8 h post infection (h.p.i) which furthered deteriorated at 24 h.p.i. Biglycan was also reduced but only 24 h.p.i. Collagen type II, although demonstrated a downward trend, it was not statistically significant, whereas both Versican and Aggrecan showed a substantial decrease at 24 h.p.i. Hyaluronan production was not significantly affected. In a non-productive HSV-1 infection, a substantial reduction of Decorin, Biglycan, Versican and Aggrecan expression was found, similarly to our findings from the lytic infection. Furthermore, collagen type II expression was completely abolished. HAS1 expression was not affected, whereas HAS 2 and 3 were found to be significantly reduced. These results indicate that HSV-1 infection of human NP cells yields a complex effect on host extracellular cell function. The viral-induced changes in proteoglycan and collagen type II concentration may affect cell-matrix interactions and lead to a dysfunctional intervertebral disc which may trigger or promote the degeneration process." @default.
• W2896770837 created "2018-10-26" @default.
• W2896770837 creator A5015474428 @default.
• W2896770837 creator A5023540490 @default.
• W2896770837 creator A5054961651 @default.
• W2896770837 creator A5059184320 @default.
• W2896770837 creator A5085005304 @default.
• W2896770837 date "2019-01-01" @default.
• W2896770837 modified "2023-10-01" @default.
• W2896770837 title "Herpes simplex virus type-1 infection affects the expression of extracellular matrix components in human nucleus pulposus cells" @default.
• W2896770837 cites W143623202 @default.
• W2896770837 cites W1516008369 @default.
• W2896770837 cites W1520612770 @default.
• W2896770837 cites W1767005109 @default.
• W2896770837 cites W1966979772 @default.
• W2896770837 cites W1973559233 @default.
• W2896770837 cites W1975155903 @default.
• W2896770837 cites W1979859583 @default.
• W2896770837 cites W1987720645 @default.
• W2896770837 cites W2002928056 @default.
• W2896770837 cites W2007413067 @default.
• W2896770837 cites W2018587908 @default.
• W2896770837 cites W2020291353 @default.
• W2896770837 cites W2024502560 @default.
• W2896770837 cites W2032518686 @default.
• W2896770837 cites W2034271959 @default.
• W2896770837 cites W2034302277 @default.
• W2896770837 cites W2040215497 @default.
• W2896770837 cites W2049081530 @default.
• W2896770837 cites W2059356397 @default.
• W2896770837 cites W2059823369 @default.
• W2896770837 cites W2069043085 @default.
• W2896770837 cites W2071694837 @default.
• W2896770837 cites W2072936530 @default.
• W2896770837 cites W2076135184 @default.
• W2896770837 cites W2077598782 @default.
• W2896770837 cites W2079875492 @default.
• W2896770837 cites W2081397410 @default.
• W2896770837 cites W2085338873 @default.
• W2896770837 cites W2112458458 @default.
• W2896770837 cites W2115872708 @default.
• W2896770837 cites W2117771108 @default.
• W2896770837 cites W2117980344 @default.
• W2896770837 cites W2124078280 @default.
• W2896770837 cites W2124912335 @default.
• W2896770837 cites W2129837271 @default.
• W2896770837 cites W2131687641 @default.
• W2896770837 cites W2140476594 @default.
• W2896770837 cites W2156987533 @default.
• W2896770837 cites W2162244084 @default.
• W2896770837 cites W2166016039 @default.
• W2896770837 cites W2181303354 @default.
• W2896770837 cites W2234409587 @default.
• W2896770837 cites W2270570738 @default.
• W2896770837 cites W2332848001 @default.
• W2896770837 cites W2334161627 @default.
• W2896770837 cites W2756923516 @default.
• W2896770837 cites W42830026 @default.
• W2896770837 doi "https://doi.org/10.1016/j.virusres.2018.10.010" @default.
• W2896770837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30339788" @default.
• W2896770837 hasPublicationYear "2019" @default.
• W2896770837 type Work @default.
• W2896770837 sameAs 2896770837 @default.
• W2896770837 citedByCount "6" @default.
• W2896770837 countsByYear W28967708372020 @default.
• W2896770837 countsByYear W28967708372021 @default.
• W2896770837 countsByYear W28967708372022 @default.
• W2896770837 countsByYear W28967708372023 @default.
• W2896770837 crossrefType "journal-article" @default.
• W2896770837 hasAuthorship W2896770837A5015474428 @default.
• W2896770837 hasAuthorship W2896770837A5023540490 @default.
• W2896770837 hasAuthorship W2896770837A5054961651 @default.
• W2896770837 hasAuthorship W2896770837A5059184320 @default.
• W2896770837 hasAuthorship W2896770837A5085005304 @default.
• W2896770837 hasConcept C105702510 @default.
• W2896770837 hasConcept C142724271 @default.
• W2896770837 hasConcept C159470946 @default.
• W2896770837 hasConcept C182615771 @default.
• W2896770837 hasConcept C189165786 @default.
• W2896770837 hasConcept C197534660 @default.
• W2896770837 hasConcept C203014093 @default.
• W2896770837 hasConcept C204787440 @default.
• W2896770837 hasConcept C2522874641 @default.
• W2896770837 hasConcept C2776164576 @default.
• W2896770837 hasConcept C2777755357 @default.
• W2896770837 hasConcept C2778916964 @default.
• W2896770837 hasConcept C2779335624 @default.
• W2896770837 hasConcept C2779794767 @default.
• W2896770837 hasConcept C2780723820 @default.
• W2896770837 hasConcept C2781196997 @default.
• W2896770837 hasConcept C3020332539 @default.
• W2896770837 hasConcept C71924100 @default.
• W2896770837 hasConcept C86803240 @default.
• W2896770837 hasConcept C95444343 @default.
• W2896770837 hasConceptScore W2896770837C105702510 @default.
• W2896770837 hasConceptScore W2896770837C142724271 @default.
• W2896770837 hasConceptScore W2896770837C159470946 @default.
• W2896770837 hasConceptScore W2896770837C182615771 @default.

• next