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- W2896772390 abstract "Improved knowledge of blood flow during CPR will provide a platform to understand howto optimise chest compression strategies, to maximise the success of this life-criticalintervention. Modelling the human circulatory system remains, however, a very difficultand challenging task because of its complexity and heterogeneity, both geometrically andfunctionally. The work in this thesis presents the simulation process developed for subjectspecificblood flow modelling of porcine left ventricle during a simulated CPR compression.The building of the process chain required for the computations was described. Theworkflow consists of the fine segmentation of porcine CT data, extraction and processingof the 3D geometrical model, generation of high-quality controlled surface and volumemeshes, definition of appropriate physical models, setting of realistic boundary conditions,and finally evaluation of the simulations. Aspects involving the computational stability andmaterial characterisations essential for reliable computations were presented. Further, theintegration of the individual steps into ANSYS including automation of the process,optimisation and the individualisation of the simulations, indispensable for a clinicalimplementation of such a subject-specific system, were described.Subject-specific model velocity profile of the blood flow from the outlet gave a similarvelocity profile and magnitude expected from a first compression of the left ventricle in aresting state. Moreover, the velocity obtained from the experimental validation modelagreed relatively well with that of the computational model giving the proposed modelvalidity to be used in the investigation of the LV blood flow during compression. Thesimulated blood viscosity profile agreed strongly with the literature blood non-Newtonianprofile.The experimental results of the present physical model agreed relatively well with the datafrom the computational model regarding the deformation of the structural part along withthe velocity magnitude. Despite the fact that the biaxial data showed that the stiffness ofthe 3D printed material was found to be lower than the tissue in the very low strain rate,the preliminary FSI model material loading during the simulation was more significant forthe choice of the hyperelastic material model.The outcomes of this research achieved the aim of implementing a fully coupled FSImethod for the design and optimization of a porcine infant left ventricle during a simulatedCPR compression. This model is considered a platform for investigating infant CPR chestcompression efficacy." @default.
- W2896772390 created "2018-10-26" @default.
- W2896772390 creator A5061282268 @default.
- W2896772390 date "2018-01-01" @default.
- W2896772390 modified "2023-09-26" @default.
- W2896772390 title "Establishing a fluid-structure interaction platform for investigating infant cardiopulmonary resuscitation" @default.
- W2896772390 hasPublicationYear "2018" @default.
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