FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896772753> ?p ?o ?g. }

• W2896772753 abstract "Leukemia and lymphoma are common hematological malignancies in children and young adults, which pose a tremendous threat to the survival of these young patients worldwide, despite availability of various effective treatments. The Hippo pathway is a novel‑signaling pathway that regulates organ size, cell proliferation, apoptosis and tumorigenesis. The chief component of this pathway is the transducer yes‑associated protein (YAP) which is over‑expressed in numerous categories of tumors. However, little is known about the effect of YAP in hematological malignancies. In the present study, YAP expression was screened in several leukemia and lymphoma cell lines, and high YAP expression was demonstrated in Jurkat cells. To further unravel its effect on the biological behavior of Jurkat cells, lentivirus transduced short hairpin RNA (shRNA) technique was used to silence YAP. As expected, the YAP‑specific shRNA dramatically inhibited YAP expression at the mRNA and protein levels. Reduced leukemia cell proliferation and increased cell apoptosis were demonstrated in YAP knockdown Jurkat cells. It was also demonstrated that YAP knockdown resulted in deregulated expression of a cluster of downstream genes crucial to cell proliferation or apoptosis, including protein kinase B, B‑cell lymphoma 2 (BCL2) and BCL2 like protein 1. Consequently, the results of the present study established that suppression of YAP expression serves an important role in Jurkat cell proliferation and apoptosis, which may serve as a potential therapeutic target." @default.
• W2896772753 created "2018-10-26" @default.
• W2896772753 creator A5026276754 @default.
• W2896772753 creator A5029203568 @default.
• W2896772753 creator A5030985084 @default.
• W2896772753 creator A5058166056 @default.
• W2896772753 creator A5064460181 @default.
• W2896772753 creator A5083932079 @default.
• W2896772753 creator A5086051416 @default.
• W2896772753 date "2018-10-15" @default.
• W2896772753 modified "2023-10-16" @default.
• W2896772753 title "Knockdown of the Hippo transducer YAP reduces proliferation and promotes apoptosis in the Jurkat leukemia cell" @default.
• W2896772753 cites W1567765448 @default.
• W2896772753 cites W1591877903 @default.
• W2896772753 cites W1983691421 @default.
• W2896772753 cites W1985268553 @default.
• W2896772753 cites W1990944630 @default.
• W2896772753 cites W1995396494 @default.
• W2896772753 cites W2003773799 @default.
• W2896772753 cites W2012880178 @default.
• W2896772753 cites W2013174659 @default.
• W2896772753 cites W2021267930 @default.
• W2896772753 cites W2031718641 @default.
• W2896772753 cites W2055889431 @default.
• W2896772753 cites W2061531755 @default.
• W2896772753 cites W2064592062 @default.
• W2896772753 cites W2073568903 @default.
• W2896772753 cites W2075452487 @default.
• W2896772753 cites W2077424015 @default.
• W2896772753 cites W2079375831 @default.
• W2896772753 cites W2090168356 @default.
• W2896772753 cites W2107277218 @default.
• W2896772753 cites W2118971140 @default.
• W2896772753 cites W2124059822 @default.
• W2896772753 cites W2134365404 @default.
• W2896772753 cites W2162730852 @default.
• W2896772753 cites W2192080449 @default.
• W2896772753 cites W2406626486 @default.
• W2896772753 cites W2409919881 @default.
• W2896772753 cites W2512575036 @default.
• W2896772753 cites W2574680859 @default.
• W2896772753 cites W2725970815 @default.
• W2896772753 cites W2768202893 @default.
• W2896772753 cites W2783668721 @default.
• W2896772753 cites W2786064714 @default.
• W2896772753 cites W4231346141 @default.
• W2896772753 doi "https://doi.org/10.3892/mmr.2018.9556" @default.
• W2896772753 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6236312" @default.
• W2896772753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30320399" @default.
• W2896772753 hasPublicationYear "2018" @default.
• W2896772753 type Work @default.
• W2896772753 sameAs 2896772753 @default.
• W2896772753 citedByCount "6" @default.
• W2896772753 countsByYear W28967727532020 @default.
• W2896772753 countsByYear W28967727532021 @default.
• W2896772753 crossrefType "journal-article" @default.
• W2896772753 hasAuthorship W2896772753A5026276754 @default.
• W2896772753 hasAuthorship W2896772753A5029203568 @default.
• W2896772753 hasAuthorship W2896772753A5030985084 @default.
• W2896772753 hasAuthorship W2896772753A5058166056 @default.
• W2896772753 hasAuthorship W2896772753A5064460181 @default.
• W2896772753 hasAuthorship W2896772753A5083932079 @default.
• W2896772753 hasAuthorship W2896772753A5086051416 @default.
• W2896772753 hasBestOaLocation W28967727531 @default.
• W2896772753 hasConcept C121608353 @default.
• W2896772753 hasConcept C1491633281 @default.
• W2896772753 hasConcept C172512520 @default.
• W2896772753 hasConcept C173396325 @default.
• W2896772753 hasConcept C179464577 @default.
• W2896772753 hasConcept C190232843 @default.
• W2896772753 hasConcept C190283241 @default.
• W2896772753 hasConcept C203014093 @default.
• W2896772753 hasConcept C2776090121 @default.
• W2896772753 hasConcept C2778461978 @default.
• W2896772753 hasConcept C2781018059 @default.
• W2896772753 hasConcept C29537977 @default.
• W2896772753 hasConcept C502942594 @default.
• W2896772753 hasConcept C54355233 @default.
• W2896772753 hasConcept C555283112 @default.
• W2896772753 hasConcept C62112901 @default.
• W2896772753 hasConcept C62478195 @default.
• W2896772753 hasConcept C86803240 @default.
• W2896772753 hasConcept C8891405 @default.
• W2896772753 hasConcept C95444343 @default.
• W2896772753 hasConceptScore W2896772753C121608353 @default.
• W2896772753 hasConceptScore W2896772753C1491633281 @default.
• W2896772753 hasConceptScore W2896772753C172512520 @default.
• W2896772753 hasConceptScore W2896772753C173396325 @default.
• W2896772753 hasConceptScore W2896772753C179464577 @default.
• W2896772753 hasConceptScore W2896772753C190232843 @default.
• W2896772753 hasConceptScore W2896772753C190283241 @default.
• W2896772753 hasConceptScore W2896772753C203014093 @default.
• W2896772753 hasConceptScore W2896772753C2776090121 @default.
• W2896772753 hasConceptScore W2896772753C2778461978 @default.
• W2896772753 hasConceptScore W2896772753C2781018059 @default.
• W2896772753 hasConceptScore W2896772753C29537977 @default.
• W2896772753 hasConceptScore W2896772753C502942594 @default.
• W2896772753 hasConceptScore W2896772753C54355233 @default.
• W2896772753 hasConceptScore W2896772753C555283112 @default.
• W2896772753 hasConceptScore W2896772753C62112901 @default.

• next