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• W2896773356 abstract "With 19–25 nucleotides long, microRNAs (miRNAs) are small noncoding RNA molecules which play crucial roles in major cellular functions such as cell cycle control, apoptosis, metabolism, cell proliferation, and cell differentiation. Changes in the expression of miRNAs can cause significant effects to normal and aberrant cells. The dysregulation of miRNAs has been implicated in various human diseases such as brain tumor, osteoarthritis, schizophrenia, and breast cancer. Generally, miRNAs negatively regulate gene expression by binding to their specific mRNAs, thereby blocking their translation of the mRNAs. However, a few studies have reported that miRNAs could also upregulate the translation of certain proteins. This shows the important roles of miRNAs in various cell functions. This chapter will focus on the role of miRNAs in normal osteoblast and osteosarcoma cells. In addition, the great potential of miRNA as a new therapeutic approach to treat human bone diseases will also be discussed." @default.
• W2896773356 created "2018-10-26" @default.
• W2896773356 creator A5000598612 @default.
• W2896773356 creator A5023102473 @default.
• W2896773356 creator A5047453603 @default.
• W2896773356 creator A5064000426 @default.
• W2896773356 date "2018-10-10" @default.
• W2896773356 modified "2023-09-27" @default.
• W2896773356 title "MicroRNAs in Bone Diseases: Progress and Prospects" @default.
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• W2896773356 doi "https://doi.org/10.5772/intechopen.79275" @default.
• W2896773356 hasPublicationYear "2018" @default.
• W2896773356 type Work @default.
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