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- W2896774438 abstract "Abstract The protection reactions of alcohols (primary and secondary) were efficiently performed applying silyl chlorides (Me 3 SiCl, Et 3 SiCl, t ‐BuMe 2 SiCl and t ‐BuPh 2 SiCl) as protecting source, on grinding, without the use of a catalyst. The reactions proceeded smoothly, either at room temperature or at 40 °C, depending on the protecting group applied, and under solvent‐free conditions. In comparison with the classical reaction conditions, which employ, most of the times, solvent in anhydrous conditions (tetrahydrofuran or N,N ‐dimethylformamide), this synthetic protocol exhibits the advantages of shorter reaction times, milder reaction conditions, higher yields and simpler purification steps. Under this method 21 examples could be obtained at short reaction times (5 – 10 min) and presenting up to 98% of yields. When the substrate was a diol bearing primary and phenolic hydroxyl moieties, the monoprotected or the diprotected product could be obtained as a sole product, in excellent yields." @default.
- W2896774438 created "2018-10-26" @default.
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- W2896774438 date "2018-10-16" @default.
- W2896774438 modified "2023-09-26" @default.
- W2896774438 title "Solvent and Catalyst-Free Synthesis of Silicon-Protected Alcohols" @default.
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- W2896774438 doi "https://doi.org/10.1002/slct.201802487" @default.
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