FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896777445> ?p ?o ?g. }

• W2896777445 endingPage "664" @default.
• W2896777445 startingPage "658" @default.
• W2896777445 abstract "Lithium is the mainstay treatment in bipolar disorder (BD) for its effectiveness in the acute phases of illness and in prevention of recurrences. Lithium's mechanism of action is complex, and while it modulates the function of hundreds of molecular targets, most of these effects could be unspecific and not relevant for its clinical efficacy. In this study, we applied an integrated analytical approach using genome‐wide expression and genotyping data from BD patients to identify lithium‐responsive genes that may serve as biomarkers of its efficacy. To this purpose, we tested the effect of treatment with lithium chloride 1 mM on the transcriptome of lymphoblasts from 10 lithium responders (LR) and 10 nonresponders (NR) patients and identified genes significantly influenced by the treatment exclusively in LR. These findings were integrated with gene‐based analysis on genome‐wide genotyping data from an extended sample of 205 BD patients characterized for lithium response. The expression of 29 genes was significantly changed by lithium exclusively in LR. Gene‐based analysis showed that two of these genes, zinc finger protein 429 (ZNF429) and zinc finger protein 493 (ZNF493), were also significantly associated with lithium response. Validation with quantitative real‐time polymerase chain reaction confirmed the lithium‐induced downregulation of ZNF493 in LR ( p = .036). Using convergent analyses of genome‐wide expression and genotyping data, we identified ZNF493 as a potential lithium‐responsive target that may be involved in modulating lithium efficacy in BD. To our knowledge, this is the first evidence supporting the involvement of zinc finger proteins in lithium response." @default.
• W2896777445 created "2018-10-26" @default.
• W2896777445 creator A5000083928 @default.
• W2896777445 creator A5023657211 @default.
• W2896777445 creator A5023736410 @default.
• W2896777445 creator A5030573407 @default.
• W2896777445 creator A5034083293 @default.
• W2896777445 creator A5048877098 @default.
• W2896777445 creator A5049155736 @default.
• W2896777445 creator A5053853143 @default.
• W2896777445 creator A5061703839 @default.
• W2896777445 creator A5063763690 @default.
• W2896777445 creator A5064011075 @default.
• W2896777445 creator A5065632375 @default.
• W2896777445 creator A5091418738 @default.
• W2896777445 date "2018-10-01" @default.
• W2896777445 modified "2023-09-29" @default.
• W2896777445 title "Convergent analysis of genome-wide genotyping and transcriptomic data suggests association of zinc finger genes with lithium response in bipolar disorder" @default.
• W2896777445 cites W1824346003 @default.
• W2896777445 cites W1833306283 @default.
• W2896777445 cites W1892930942 @default.
• W2896777445 cites W1965959226 @default.
• W2896777445 cites W1974702488 @default.
• W2896777445 cites W1977538823 @default.
• W2896777445 cites W1978382321 @default.
• W2896777445 cites W1979665154 @default.
• W2896777445 cites W1991875060 @default.
• W2896777445 cites W1998308540 @default.
• W2896777445 cites W2000766814 @default.
• W2896777445 cites W2011782794 @default.
• W2896777445 cites W2016907728 @default.
• W2896777445 cites W2017446917 @default.
• W2896777445 cites W2018716777 @default.
• W2896777445 cites W2025700197 @default.
• W2896777445 cites W2026300333 @default.
• W2896777445 cites W2049165791 @default.
• W2896777445 cites W2049480904 @default.
• W2896777445 cites W2051314902 @default.
• W2896777445 cites W2078053925 @default.
• W2896777445 cites W2078925876 @default.
• W2896777445 cites W2081098333 @default.
• W2896777445 cites W2095417278 @default.
• W2896777445 cites W2097870615 @default.
• W2896777445 cites W2103693302 @default.
• W2896777445 cites W2107116316 @default.
• W2896777445 cites W2111096670 @default.
• W2896777445 cites W2121247237 @default.
• W2896777445 cites W2121408857 @default.
• W2896777445 cites W2136422355 @default.
• W2896777445 cites W2145920585 @default.
• W2896777445 cites W2148533501 @default.
• W2896777445 cites W2157752701 @default.
• W2896777445 cites W2160697532 @default.
• W2896777445 cites W2161633633 @default.
• W2896777445 cites W2170989872 @default.
• W2896777445 cites W2175689656 @default.
• W2896777445 cites W2185709237 @default.
• W2896777445 cites W2262279506 @default.
• W2896777445 cites W2339734077 @default.
• W2896777445 doi "https://doi.org/10.1002/ajmg.b.32663" @default.
• W2896777445 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6230310" @default.
• W2896777445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30318722" @default.
• W2896777445 hasPublicationYear "2018" @default.
• W2896777445 type Work @default.
• W2896777445 sameAs 2896777445 @default.
• W2896777445 citedByCount "10" @default.
• W2896777445 countsByYear W28967774452019 @default.
• W2896777445 countsByYear W28967774452020 @default.
• W2896777445 countsByYear W28967774452021 @default.
• W2896777445 countsByYear W28967774452022 @default.
• W2896777445 countsByYear W28967774452023 @default.
• W2896777445 crossrefType "journal-article" @default.
• W2896777445 hasAuthorship W2896777445A5000083928 @default.
• W2896777445 hasAuthorship W2896777445A5023657211 @default.
• W2896777445 hasAuthorship W2896777445A5023736410 @default.
• W2896777445 hasAuthorship W2896777445A5030573407 @default.
• W2896777445 hasAuthorship W2896777445A5034083293 @default.
• W2896777445 hasAuthorship W2896777445A5048877098 @default.
• W2896777445 hasAuthorship W2896777445A5049155736 @default.
• W2896777445 hasAuthorship W2896777445A5053853143 @default.
• W2896777445 hasAuthorship W2896777445A5061703839 @default.
• W2896777445 hasAuthorship W2896777445A5063763690 @default.
• W2896777445 hasAuthorship W2896777445A5064011075 @default.
• W2896777445 hasAuthorship W2896777445A5065632375 @default.
• W2896777445 hasAuthorship W2896777445A5091418738 @default.
• W2896777445 hasBestOaLocation W28967774452 @default.
• W2896777445 hasConcept C104317684 @default.
• W2896777445 hasConcept C134018914 @default.
• W2896777445 hasConcept C135763542 @default.
• W2896777445 hasConcept C141231307 @default.
• W2896777445 hasConcept C150194340 @default.
• W2896777445 hasConcept C162317418 @default.
• W2896777445 hasConcept C24284526 @default.
• W2896777445 hasConcept C2776174506 @default.
• W2896777445 hasConcept C2778541603 @default.
• W2896777445 hasConcept C31467283 @default.
• W2896777445 hasConcept C54355233 @default.
• W2896777445 hasConcept C86339819 @default.

• next