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• W2896777737 abstract "Summary During mitosis, the centrosome acts as a microtubule organizing center (MTOC), orchestrating microtubules into the mitotic spindle through its pericentriolar material (PCM). This activity is biphasic, cycling through assembly and disassembly during the cell cycle. Although hyperactive centrosomal MTOC activity is a hallmark of some cancers, little is known about how the centrosome is inactivated as an MTOC. Analysis of endogenous PCM proteins in C. elegans revealed that the PCM is composed of distinct protein territories that are removed from the centrosome at different rates and using different behaviors. Inhibition of PP2A phosphatases stabilized the PCM and perturbation of cortical pulling forces altered the timing and behavior by which proteins were removed from the centrosome. These data indicate that PCM disassembly is a two-step process, beginning with a phosphatase-dependent dissolution of PCM proteins followed by the ejection of ruptured PCM by cortical forces, ultimately inactivating MTOC function at the centrosome." @default.
• W2896777737 created "2018-10-26" @default.
• W2896777737 creator A5009672213 @default.
• W2896777737 creator A5010411927 @default.
• W2896777737 creator A5043360580 @default.
• W2896777737 date "2018-10-17" @default.
• W2896777737 modified "2023-09-24" @default.
• W2896777737 title "A two-step mechanism for the inactivation of microtubule organizing center function at the centrosome" @default.
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• W2896777737 doi "https://doi.org/10.1101/446088" @default.
• W2896777737 hasPublicationYear "2018" @default.
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