FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896780580> ?p ?o ?g. }

• W2896780580 endingPage "329" @default.
• W2896780580 startingPage "324" @default.
• W2896780580 abstract "Hepatocellular carcinoma (HCC) is a common malignancy found throughout the world that most often occurs in males. The cancer is associated with many risk factors such as viral infection, cirrhosis, alcohol, smoking, and fungal toxins. GSTM1 and GSTT1 are detoxification enzymes activated by the cleansing of carcinogenic compounds. Low DNA copy numbers of Glutathione S-transferases M1 and T1 result in a loss of enzyme activity, which causes carcinogenesis factors. DNA copy number variants (CNVs) were determined to compare the differences between the frequencies of GSTM1 and GSTT1 in a control group and patients. Then, the association of these genes with the pathological/survival status of HCC patients was investigated.Forty-nine Thai HCC patients' DNA and the genomic DNA of 66 healthy controls were investigated for GSTM1 and GSTT1 CNVs by real-time polymerase chain reaction (PCR). Then, the correlations between GSTM1 and GSTT1 patients' CNVs, the control group, and clinico-pathological parameters were determined.The results show that were no differences between the CNVs of GSTM1 and GSTT1 in the controls and patients (P≥0.05). Only GSTT1 genotypes 0/0 correlated to an increase in the risk of hepatocellular carcinogenesis (OR value was 1.88). GSTM1 CNVs were associated with the gender of patients (P=0.002). However, no correlations were found between GSTT1 CNVs and any of the clinico-pathological parameters.The results suggest that only GSTT1 CNVs are associated with increased risk factors of HCC in Thais. GSTM1 copy numbers had a dominant correlation with female HCC patients." @default.
• W2896780580 created "2018-10-26" @default.
• W2896780580 creator A5000427934 @default.
• W2896780580 creator A5008277531 @default.
• W2896780580 creator A5046434968 @default.
• W2896780580 date "2019-04-01" @default.
• W2896780580 modified "2023-10-14" @default.
• W2896780580 title "GSTM1 and GSTT1 copy number variants and the risk to Thai females of hepatocellular carcinoma" @default.
• W2896780580 cites W1494281102 @default.
• W2896780580 cites W1592388468 @default.
• W2896780580 cites W1964791478 @default.
• W2896780580 cites W1974352222 @default.
• W2896780580 cites W1981989535 @default.
• W2896780580 cites W1987177482 @default.
• W2896780580 cites W1988945101 @default.
• W2896780580 cites W2002681738 @default.
• W2896780580 cites W2032331262 @default.
• W2896780580 cites W2032487617 @default.
• W2896780580 cites W2032522259 @default.
• W2896780580 cites W2035313170 @default.
• W2896780580 cites W2048062115 @default.
• W2896780580 cites W2061787766 @default.
• W2896780580 cites W2064669240 @default.
• W2896780580 cites W2066709721 @default.
• W2896780580 cites W2127737179 @default.
• W2896780580 cites W2141713243 @default.
• W2896780580 cites W2167971774 @default.
• W2896780580 cites W2279355599 @default.
• W2896780580 cites W2316328350 @default.
• W2896780580 cites W2333755772 @default.
• W2896780580 cites W2602163211 @default.
• W2896780580 cites W2735882090 @default.
• W2896780580 doi "https://doi.org/10.21037/jgo.2018.09.14" @default.
• W2896780580 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6465500" @default.
• W2896780580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31032101" @default.
• W2896780580 hasPublicationYear "2019" @default.
• W2896780580 type Work @default.
• W2896780580 sameAs 2896780580 @default.
• W2896780580 citedByCount "6" @default.
• W2896780580 countsByYear W28967805802019 @default.
• W2896780580 countsByYear W28967805802020 @default.
• W2896780580 countsByYear W28967805802021 @default.
• W2896780580 countsByYear W28967805802022 @default.
• W2896780580 crossrefType "journal-article" @default.
• W2896780580 hasAuthorship W2896780580A5000427934 @default.
• W2896780580 hasAuthorship W2896780580A5008277531 @default.
• W2896780580 hasAuthorship W2896780580A5046434968 @default.
• W2896780580 hasBestOaLocation W28967805801 @default.
• W2896780580 hasConcept C104317684 @default.
• W2896780580 hasConcept C120821319 @default.
• W2896780580 hasConcept C121608353 @default.
• W2896780580 hasConcept C126322002 @default.
• W2896780580 hasConcept C141231307 @default.
• W2896780580 hasConcept C143998085 @default.
• W2896780580 hasConcept C207886595 @default.
• W2896780580 hasConcept C2777214474 @default.
• W2896780580 hasConcept C2778019345 @default.
• W2896780580 hasConcept C2779399171 @default.
• W2896780580 hasConcept C49105822 @default.
• W2896780580 hasConcept C54355233 @default.
• W2896780580 hasConcept C555283112 @default.
• W2896780580 hasConcept C71924100 @default.
• W2896780580 hasConcept C86803240 @default.
• W2896780580 hasConcept C90924648 @default.
• W2896780580 hasConceptScore W2896780580C104317684 @default.
• W2896780580 hasConceptScore W2896780580C120821319 @default.
• W2896780580 hasConceptScore W2896780580C121608353 @default.
• W2896780580 hasConceptScore W2896780580C126322002 @default.
• W2896780580 hasConceptScore W2896780580C141231307 @default.
• W2896780580 hasConceptScore W2896780580C143998085 @default.
• W2896780580 hasConceptScore W2896780580C207886595 @default.
• W2896780580 hasConceptScore W2896780580C2777214474 @default.
• W2896780580 hasConceptScore W2896780580C2778019345 @default.
• W2896780580 hasConceptScore W2896780580C2779399171 @default.
• W2896780580 hasConceptScore W2896780580C49105822 @default.
• W2896780580 hasConceptScore W2896780580C54355233 @default.
• W2896780580 hasConceptScore W2896780580C555283112 @default.
• W2896780580 hasConceptScore W2896780580C71924100 @default.
• W2896780580 hasConceptScore W2896780580C86803240 @default.
• W2896780580 hasConceptScore W2896780580C90924648 @default.
• W2896780580 hasIssue "2" @default.
• W2896780580 hasLocation W28967805801 @default.
• W2896780580 hasLocation W28967805802 @default.
• W2896780580 hasLocation W28967805803 @default.
• W2896780580 hasLocation W28967805804 @default.
• W2896780580 hasOpenAccess W2896780580 @default.
• W2896780580 hasPrimaryLocation W28967805801 @default.
• W2896780580 hasRelatedWork W2026902286 @default.
• W2896780580 hasRelatedWork W2034000389 @default.
• W2896780580 hasRelatedWork W2255318257 @default.
• W2896780580 hasRelatedWork W2266860383 @default.
• W2896780580 hasRelatedWork W2324406516 @default.
• W2896780580 hasRelatedWork W2412677110 @default.
• W2896780580 hasRelatedWork W2466683206 @default.
• W2896780580 hasRelatedWork W3030449887 @default.
• W2896780580 hasRelatedWork W3091367366 @default.
• W2896780580 hasRelatedWork W1967622845 @default.
• W2896780580 hasVolume "10" @default.

• next