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- W2896784668 abstract "To assess the prognostic value of combined fetal ultrasound and MRI along with fetal blood analysis. We reviewed all cases of proven fetal CMV infection (positive amniocentesis) following primary infection mainly in the first trimester, between 2008 and 2017 with well documented postnatal or post-mortem outcome. Prenatal ultrasound and MRI features along with CMV DNA load in fetal blood and fetal platelet count were reviewed in relation with outcome. Maternal treatment with valaciclovir (8g/day) was accounted for in symptomatic fetuses. Fetal symptoms included extracerebral and cerebral ultrasound and MRI CMV-related features (2016. Am J Obstet Gynecol. 215(3):342–50) as well as values for CMV-DNA and platelet count in fetal blood above and below 5 log/ml and 110, 000/dL respectively. 118 infected fetuses mainly from first trimester maternal primary infection were diagnosed which 60 (66,1%) showed features of infection on ultrasound and/or MRI. Fetal blood profile was abnormal in 54 (61,4%) cases that underwent cordocentesis. At 26+2 (22+5-30+4) weeks', PPV and NPV for ultrasound were 66% and 83% rising to 83% and 86% respectively when combining fetal blood results. At 32+3 (31+2-33+2) weeks' PPV and NPV for MRI and accounting for previous US results and treatment with valaciclovir of symptomatic fetuses, were 78% and 75% rising to 91% and 89% respectively when combining fetal blood results. Prognostic evaluation improved from 2nd to 3rd trimester with the addition of MRI. Accounting for fetal blood parameters recorded at cordocentesis in 2nd trimester significantly improves prediction of a symptomatic or asymptomatic status at birth both in 2nd and 3rd trimesters. Symptoms that could not be predicted consisted of partial and mainly unilateral hearing loss." @default.
- W2896784668 created "2018-10-26" @default.
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- W2896784668 date "2018-10-01" @default.
- W2896784668 modified "2023-10-18" @default.
- W2896784668 title "OC21.04: Prediction of outcome of fetal infection with cytomegalovirus (CMV)" @default.
- W2896784668 doi "https://doi.org/10.1002/uog.19349" @default.
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