FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896789425> ?p ?o ?g. }

• W2896789425 endingPage "7343" @default.
• W2896789425 startingPage "7333" @default.
• W2896789425 abstract "Down-regulation of CXCL 11 inhibits colorectal cancer cell growth and epithelial-mesenchymal transition Yu Jie Gao,1 De Lin Liu,2 Sheng Li,2 Gao Feng Yuan,1 Li Li,1 Hong Yan Zhu,3 Guan Yi Cao3 1Department of Medical Oncology, Suqian First Hospital, Suqian, Jiangsu, China; 2Department of Medical Oncology, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu, China; 3Department of General Surgery, Suqian First Hospital, Suqian, Jiangsu, China Background: The poor prognosis of colorectal cancer (CRC) largely results from local invasion and tumor metastases. Epithelial-mesenchymal transition (EMT) is a key step in the progression of solid tumors and plays a vital role in tumor metastasis. Recent studies demonstrate that C-X-C motif chemokine 11 (CXCL11) is involved in various cancers’ progression. However, its biological activity in CRC needs deeper exploration. Methods: The level of CXCL11 in CRC tissues and cell lines was determined using the quantitative real-time PCR (qRT-PCR) assay. The MTT, colony formation, wound healing and Transwell invasion assays were applied to assess the role of CXCL11 in CRC cell growth, migration and invasion, in vitro, respectively. A xenograft model was constructed to analyze the function of CXCL11 in CRC cell growth in vivo. Results: CXCL11 was over-expressed in CRC tissues and cell lines. Repression of CXCL11 significantly inhibited CRC cell migration, invasion and EMT in vitro. In addition, down-regulation of CXCL11 reduced CRC cell growth and metastasis in vivo. Finally, we revealed that repression of CXCL11 inhibited the metastatic ability of CRC cell in a N-cadherin dependent manner. Conclusion: In summary, this study explicates the oncogenic activities of CXCL11 in CRC cell growth and metastasis. Keywords: colon cancer, CXCL11, migration, invasion, EMT" @default.
• W2896789425 created "2018-10-26" @default.
• W2896789425 creator A5004685226 @default.
• W2896789425 creator A5007463891 @default.
• W2896789425 creator A5020357508 @default.
• W2896789425 creator A5026512168 @default.
• W2896789425 creator A5027475930 @default.
• W2896789425 creator A5054261528 @default.
• W2896789425 creator A5067957605 @default.
• W2896789425 date "2018-10-01" @default.
• W2896789425 modified "2023-09-26" @default.
• W2896789425 title "Down-regulation of CXCL 11 inhibits colorectal cancer cell growth and epithelial-mesenchymal transition" @default.
• W2896789425 cites W1499412587 @default.
• W2896789425 cites W1965531953 @default.
• W2896789425 cites W1985050690 @default.
• W2896789425 cites W2011474505 @default.
• W2896789425 cites W2017985095 @default.
• W2896789425 cites W2050245934 @default.
• W2896789425 cites W2094845673 @default.
• W2896789425 cites W2127594372 @default.
• W2896789425 cites W2233997950 @default.
• W2896789425 cites W2334423374 @default.
• W2896789425 cites W2560372657 @default.
• W2896789425 cites W260290962 @default.
• W2896789425 cites W2614055265 @default.
• W2896789425 cites W2768351947 @default.
• W2896789425 cites W2770893462 @default.
• W2896789425 cites W2776281641 @default.
• W2896789425 cites W2780409833 @default.
• W2896789425 cites W2780465293 @default.
• W2896789425 cites W2782190913 @default.
• W2896789425 cites W2785460122 @default.
• W2896789425 cites W2789084399 @default.
• W2896789425 cites W2791968111 @default.
• W2896789425 cites W2792873661 @default.
• W2896789425 cites W2806927747 @default.
• W2896789425 doi "https://doi.org/10.2147/ott.s167872" @default.
• W2896789425 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6205823" @default.
• W2896789425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30425523" @default.
• W2896789425 hasPublicationYear "2018" @default.
• W2896789425 type Work @default.
• W2896789425 sameAs 2896789425 @default.
• W2896789425 citedByCount "35" @default.
• W2896789425 countsByYear W28967894252019 @default.
• W2896789425 countsByYear W28967894252020 @default.
• W2896789425 countsByYear W28967894252021 @default.
• W2896789425 countsByYear W28967894252022 @default.
• W2896789425 crossrefType "journal-article" @default.
• W2896789425 hasAuthorship W2896789425A5004685226 @default.
• W2896789425 hasAuthorship W2896789425A5007463891 @default.
• W2896789425 hasAuthorship W2896789425A5020357508 @default.
• W2896789425 hasAuthorship W2896789425A5026512168 @default.
• W2896789425 hasAuthorship W2896789425A5027475930 @default.
• W2896789425 hasAuthorship W2896789425A5054261528 @default.
• W2896789425 hasAuthorship W2896789425A5067957605 @default.
• W2896789425 hasBestOaLocation W28967894251 @default.
• W2896789425 hasConcept C121608353 @default.
• W2896789425 hasConcept C126322002 @default.
• W2896789425 hasConcept C137738243 @default.
• W2896789425 hasConcept C143998085 @default.
• W2896789425 hasConcept C2779013556 @default.
• W2896789425 hasConcept C502942594 @default.
• W2896789425 hasConcept C526805850 @default.
• W2896789425 hasConcept C54355233 @default.
• W2896789425 hasConcept C62112901 @default.
• W2896789425 hasConcept C71924100 @default.
• W2896789425 hasConcept C76419328 @default.
• W2896789425 hasConcept C81885089 @default.
• W2896789425 hasConcept C86803240 @default.
• W2896789425 hasConceptScore W2896789425C121608353 @default.
• W2896789425 hasConceptScore W2896789425C126322002 @default.
• W2896789425 hasConceptScore W2896789425C137738243 @default.
• W2896789425 hasConceptScore W2896789425C143998085 @default.
• W2896789425 hasConceptScore W2896789425C2779013556 @default.
• W2896789425 hasConceptScore W2896789425C502942594 @default.
• W2896789425 hasConceptScore W2896789425C526805850 @default.
• W2896789425 hasConceptScore W2896789425C54355233 @default.
• W2896789425 hasConceptScore W2896789425C62112901 @default.
• W2896789425 hasConceptScore W2896789425C71924100 @default.
• W2896789425 hasConceptScore W2896789425C76419328 @default.
• W2896789425 hasConceptScore W2896789425C81885089 @default.
• W2896789425 hasConceptScore W2896789425C86803240 @default.
• W2896789425 hasLocation W28967894251 @default.
• W2896789425 hasLocation W28967894252 @default.
• W2896789425 hasLocation W28967894253 @default.
• W2896789425 hasLocation W28967894254 @default.
• W2896789425 hasOpenAccess W2896789425 @default.
• W2896789425 hasPrimaryLocation W28967894251 @default.
• W2896789425 hasRelatedWork W1970423756 @default.
• W2896789425 hasRelatedWork W2092623911 @default.
• W2896789425 hasRelatedWork W2100044165 @default.
• W2896789425 hasRelatedWork W2255000697 @default.
• W2896789425 hasRelatedWork W2295552376 @default.
• W2896789425 hasRelatedWork W2461728256 @default.
• W2896789425 hasRelatedWork W2937327588 @default.
• W2896789425 hasRelatedWork W3022892502 @default.
• W2896789425 hasRelatedWork W3041026090 @default.
• W2896789425 hasRelatedWork W4248542331 @default.

• next