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- W2896790022 abstract "The c-ros oncogene 1 (ROS1) fusion is almost mutually exclusive to MET amplication in non-small cell lung cancer (NSCLC), and it is not seen in the literature for patients to exhibitthree mutations. A 66-year-old female diagnosed with IV stage adenocarcinoma, who was shown to have ROS1 fusion and MET amplication by fluorescence in situ hybridization (FISH), and verified by next generation sequencing. The patient with right lung tumor and brain metastases NSCLC. Histological examination of surgical sepecimens from primary focus show adenocarcinoma. By fluorescence in situ hybridization (FISH), we found ROS1 fusion and MET amplication. Then we verified a novel ROS1fusion: ZCCHC8-ROS1, and the patient experienced a remarkable tumor response to crizotinib for 6 months (PFS). To the best of to our knowledge, this is the first case report of a patient with concurrent ROS1 fusion and MET amplication, and ZCCHC8-ROS1. This patient had an excellent response to crizotinib, suggesting that concurrent ROS1 fusion and MET amplication response to crizotinib was less than ROS1 fusion single driver." @default.
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- W2896790022 date "2018-10-01" @default.
- W2896790022 modified "2023-09-28" @default.
- W2896790022 title "P3.CR-11 ROS1 Fusion and MET Amplification Dual Drive Coexistence in Lung Adenocarcinoma and Response to Crizotinib: A Case Report" @default.
- W2896790022 doi "https://doi.org/10.1016/j.jtho.2018.08.1990" @default.
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