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• W2896790247 abstract "Protopanaxadiol (PPD), an active triterpene compound, is the precursor of high-value ginsenosides. In this study, we report a strategy for the enhancement of PPD production in Saccharomyces cerevisiae by cofermentation of glucose and xylose. In mixed sugar fermentation, strain GW6 showed higher PPD titer and yield than that obtained from glucose cultivation. Then, engineering strategies were implemented on GW6 to enhance the PPD yields, such as adjustment of the central carbon metabolism, optimization of the mevalonate pathway, reinforcement of the xylose assimilation pathway, and regulation of cofactor balance, namely, overexpression of xPK/PTA, ERG10/ERG12/ERG13, XYL1/XYL2/TAL1, and POS5, respectively. In particular, the final obtained strain GW10, harboring overexpressed POS5, exhibited the highest PPD yield, which was 2.06 mg of PPD/g of mixed sugar. In a 5-L fermenter, PPD titer reached 152.37 mg/L. These promising results demonstrate the great advantages of mixed sugar over glucose for high-yield production of PPD." @default.
• W2896790247 created "2018-10-26" @default.
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• W2896790247 date "2018-10-23" @default.
• W2896790247 modified "2023-09-24" @default.
• W2896790247 title "Engineering <i>Saccharomyces cerevisiae</i> for Enhanced Production of Protopanaxadiol with Cofermentation of Glucose and Xylose" @default.
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• W2896790247 doi "https://doi.org/10.1021/acs.jafc.8b04916" @default.
• W2896790247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30350965" @default.
• W2896790247 hasPublicationYear "2018" @default.
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