Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896790318> ?p ?o ?g. }
- W2896790318 endingPage "91" @default.
- W2896790318 startingPage "66" @default.
- W2896790318 abstract "Background: Alkylphospholipids (APLs) are synthetically derived from cell membrane components, which they target and thus modify cellular signalling and cause diverse effects. This study reviews the mechanism of action of anticancer, antiprotozoal, antibacterial and antiviral activities of ALPs, as well as their clinical use. Methods: A literature search was used as the basis of this review. Results: ALPs target lipid rafts and alter phospholipase D and C signalling cascades, which in turn will modulate the PI3K/Akt/mTOR and RAS/RAF/MEK/ERK pathways. By feedback coupling, the SAPK/JNK signalling chain is also affected. These changes lead to a G2/M phase cell cycle arrest and subsequently induce programmed cell death. The available knowledge on inhibition of AKT phosphorylation, mTOR phosphorylation and Raf down-regulation renders ALPs as attractive candidates for modern medical treatment, which is based on individualized diagnosis and therapy. Corresponding to their unusual profile of activities, their side effects result from cholinomimetic activity mainly and focus on the gastrointestinal tract. These aspects together with their bone marrow sparing features render APCs well suited for modern combination therapy. Although the clinical success has been limited in cancer diseases so far, the use of miltefosine against leishmaniosis is leading the way to better understanding their optimized use. Conclusion: Recent synthetic programs generate congeners with the increased therapeutic ratio, liposomal formulations, as well as diapeutic (or theranostic) derivatives with optimized properties. It is anticipated that these innovative modifications will pave the way for the further successful development of ALPs." @default.
- W2896790318 created "2018-10-26" @default.
- W2896790318 creator A5022970757 @default.
- W2896790318 creator A5038807067 @default.
- W2896790318 creator A5053719188 @default.
- W2896790318 creator A5064332179 @default.
- W2896790318 date "2019-05-08" @default.
- W2896790318 modified "2023-10-14" @default.
- W2896790318 title "Alkylphospholipids are Signal Transduction Modulators with Potential for Anticancer Therapy" @default.
- W2896790318 cites W12170387 @default.
- W2896790318 cites W1564576446 @default.
- W2896790318 cites W1571056179 @default.
- W2896790318 cites W1773841220 @default.
- W2896790318 cites W1938321078 @default.
- W2896790318 cites W1960406178 @default.
- W2896790318 cites W1965645145 @default.
- W2896790318 cites W1966133006 @default.
- W2896790318 cites W1966862537 @default.
- W2896790318 cites W1968263552 @default.
- W2896790318 cites W1971002996 @default.
- W2896790318 cites W1972334526 @default.
- W2896790318 cites W1972390625 @default.
- W2896790318 cites W1972943971 @default.
- W2896790318 cites W1973453420 @default.
- W2896790318 cites W1974381618 @default.
- W2896790318 cites W1974420223 @default.
- W2896790318 cites W1974649364 @default.
- W2896790318 cites W1977448894 @default.
- W2896790318 cites W1978091045 @default.
- W2896790318 cites W1978377333 @default.
- W2896790318 cites W1978605483 @default.
- W2896790318 cites W1979649191 @default.
- W2896790318 cites W1980376409 @default.
- W2896790318 cites W1980815474 @default.
- W2896790318 cites W1981052904 @default.
- W2896790318 cites W1985964913 @default.
- W2896790318 cites W1988460195 @default.
- W2896790318 cites W1988546147 @default.
- W2896790318 cites W1991260580 @default.
- W2896790318 cites W1991463695 @default.
- W2896790318 cites W1991618461 @default.
- W2896790318 cites W1991674117 @default.
- W2896790318 cites W1992361007 @default.
- W2896790318 cites W1993633440 @default.
- W2896790318 cites W1994626051 @default.
- W2896790318 cites W1996094668 @default.
- W2896790318 cites W1997932312 @default.
- W2896790318 cites W1999034493 @default.
- W2896790318 cites W2000525583 @default.
- W2896790318 cites W2004247994 @default.
- W2896790318 cites W2004469056 @default.
- W2896790318 cites W2004504718 @default.
- W2896790318 cites W2004538436 @default.
- W2896790318 cites W2005058529 @default.
- W2896790318 cites W2005533813 @default.
- W2896790318 cites W2005880838 @default.
- W2896790318 cites W2005922899 @default.
- W2896790318 cites W2006061622 @default.
- W2896790318 cites W2006298982 @default.
- W2896790318 cites W2006941041 @default.
- W2896790318 cites W2007959663 @default.
- W2896790318 cites W2007998678 @default.
- W2896790318 cites W2009007155 @default.
- W2896790318 cites W2009981964 @default.
- W2896790318 cites W2010310448 @default.
- W2896790318 cites W2010461655 @default.
- W2896790318 cites W2012200757 @default.
- W2896790318 cites W2012271054 @default.
- W2896790318 cites W2013782816 @default.
- W2896790318 cites W2014961333 @default.
- W2896790318 cites W2015010911 @default.
- W2896790318 cites W2015417856 @default.
- W2896790318 cites W2017981328 @default.
- W2896790318 cites W2019558984 @default.
- W2896790318 cites W2023732508 @default.
- W2896790318 cites W2023823393 @default.
- W2896790318 cites W2024025010 @default.
- W2896790318 cites W2024902882 @default.
- W2896790318 cites W2025486703 @default.
- W2896790318 cites W2027115732 @default.
- W2896790318 cites W2028525522 @default.
- W2896790318 cites W2028730118 @default.
- W2896790318 cites W2029065481 @default.
- W2896790318 cites W2029211755 @default.
- W2896790318 cites W2029261380 @default.
- W2896790318 cites W2030756885 @default.
- W2896790318 cites W2032352006 @default.
- W2896790318 cites W2033210402 @default.
- W2896790318 cites W2033585196 @default.
- W2896790318 cites W2034149848 @default.
- W2896790318 cites W2034199371 @default.
- W2896790318 cites W2036353575 @default.
- W2896790318 cites W2036949585 @default.
- W2896790318 cites W2037754829 @default.
- W2896790318 cites W2037979021 @default.
- W2896790318 cites W2038464032 @default.
- W2896790318 cites W2038685526 @default.
- W2896790318 cites W2038701060 @default.