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• W2896793382 abstract "There are accumulating reports for the potential role of Interleukin-6 (IL-6) rs1800796 polymorphism in the risk of periodontitis. However, distinct conclusions are observed. In this study, we have an interest in comprehensively analyzing the genetic relationship between IL-6 rs1800796 and the susceptibility to periodontitis.We retrieved the eligible case-control studies from on-line database and conducted a meta-analysis. P-value of association test, OR (odd ratios) and 95% CI (confidence interval) were calculated for the assessment of potential genetic association.We enrolled a total of 20 case-control studies for pooling analysis. A positive association between periodontitis cases and controls was observed in the overall meta-analysis under all genetic models (all P < 0.05, OR > 1). Similar results were detected in the population-based, PB and China subgroups (all P < 0.05, OR > 1). In the Asian subgroup, there is an increased periodontitis risk under the allele, homozygote, heterozygote, dominant and carrier models (all P < 0.05, OR > 1). Nevertheless, negative results were found in the Caucasian subgroup under all models [all P > 0.05]. In addition, a positive association between IL-6 rs1800796 and the risk of chronic periodontitis was detected under the models of allele [G vs. C], GG vs. CC, GG vs. CC+ CG and carrier [G vs. C] (all P < 0.05, OR > 1).IL-6 rs1800796 may serve as one genetic risk factor for periodontitis patients in the Asian population, especially the Chinese population. G/G genotype of IL-6 rs1800796 appears to be associated with an increased risk of chronic periodontitis." @default.
• W2896793382 created "2018-10-26" @default.
• W2896793382 creator A5005894447 @default.
• W2896793382 creator A5020575707 @default.
• W2896793382 creator A5070014390 @default.
• W2896793382 date "2018-10-09" @default.
• W2896793382 modified "2023-10-01" @default.
• W2896793382 title "Genetic Relationship Between <i>IL-6</i> rs1800796 Polymorphism and Susceptibility to Periodontitis" @default.
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• W2896793382 doi "https://doi.org/10.1080/08820139.2018.1517365" @default.
• W2896793382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30300034" @default.
• W2896793382 hasPublicationYear "2018" @default.
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