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• W2896794788 abstract "Ischemia which leads to heart attacks and strokes is one of the major causes of death in the world. Whether an occlusion occurs or not depends on the ability of a growing thrombus to resist flow forces exerted on its structure. This manuscript provides the first known in vivo measurement of how much stress a clot can withstand, before yielding to the surrounding blood flow. Namely, Lattice-Boltzmann Method flow simulations are performed based on 3D clot geometries, which are estimated from intravital microscopy images of laser-induced injuries in cremaster microvasculature of live mice. In addition to reporting the blood clot yield stresses, we also show that the thrombus core does not experience significant deformation, while its shell does. This indicates that the shell is more prone to embolization. Therefore, drugs should be designed to target the shell selectively, while leaving the core intact to minimize excessive bleeding. Finally, we laid down a foundation for a nondimensionalization procedure which unraveled a relationship between clot mechanics and biology. Hence, the proposed framework could ultimately lead to a unified theory of thrombogenesis, capable of explaining all clotting events. Thus, the findings presented herein will be beneficial to the understanding and treatment of heart attacks, strokes and hemophilia." @default.
• W2896794788 created "2018-10-26" @default.
• W2896794788 creator A5020470730 @default.
• W2896794788 creator A5023499479 @default.
• W2896794788 creator A5063556631 @default.
• W2896794788 creator A5071910655 @default.
• W2896794788 date "2019-03-01" @default.
• W2896794788 modified "2023-10-15" @default.
• W2896794788 title "In vivo measurement of blood clot mechanics from computational fluid dynamics based on intravital microscopy images" @default.
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• W2896794788 doi "https://doi.org/10.1016/j.compbiomed.2019.01.001" @default.
• W2896794788 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6390965" @default.
• W2896794788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30660757" @default.
• W2896794788 hasPublicationYear "2019" @default.
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