Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896800569> ?p ?o ?g. }
- W2896800569 abstract "Abstract Variation in reproductive lifespan and female fertility have implications for health, population size and ageing. Fertility declines well before general signs of menopause and is also adversely affected by common reproductive diseases, including polycystic ovarian syndrome (PCOS) and endometriosis. Understanding the factors that regulate the timing of puberty and menopause, and the relationships with fertility are important for individuals and for policy. Substantial genetic variation exists for common traits associated with reproductive lifespan and for common diseases influencing female fertility. Genetic studies have identified mutations in genes contributing to disorders of reproduction, and in the last ten years, genome-wide association studies (GWAS) have transformed our understanding of common genetic contributions to these complex traits and diseases. These studies have made great progress towards understanding the genetic factors contributing to variation in traits and diseases influencing female fertility. The data emerging from GWAS demonstrate the utility of genetics to explain epidemiological observations, revealing shared biological pathways linking puberty timing, fertility, reproductive ageing and health outcomes. Many variants implicate DNA damage/repair genes in variation in the age at menopause with implications for follicle health and ageing. In addition to the discovery of individual genes and pathways, the increasingly powerful studies on common genetic risk factors help interpret the underlying relationships and direction of causation in the regulation of reproductive lifespan, fertility and related traits." @default.
- W2896800569 created "2018-10-26" @default.
- W2896800569 creator A5011288738 @default.
- W2896800569 creator A5034283738 @default.
- W2896800569 creator A5064749062 @default.
- W2896800569 date "2018-10-12" @default.
- W2896800569 modified "2023-10-12" @default.
- W2896800569 title "Complex genetics of female fertility" @default.
- W2896800569 cites W1128977061 @default.
- W2896800569 cites W1492235692 @default.
- W2896800569 cites W1501791679 @default.
- W2896800569 cites W1543017846 @default.
- W2896800569 cites W1576212228 @default.
- W2896800569 cites W1577097214 @default.
- W2896800569 cites W1594932835 @default.
- W2896800569 cites W1885849841 @default.
- W2896800569 cites W1895171560 @default.
- W2896800569 cites W1904407543 @default.
- W2896800569 cites W1908598451 @default.
- W2896800569 cites W1913232349 @default.
- W2896800569 cites W1926000511 @default.
- W2896800569 cites W1965756118 @default.
- W2896800569 cites W1974161548 @default.
- W2896800569 cites W1974717633 @default.
- W2896800569 cites W1977932419 @default.
- W2896800569 cites W1978720848 @default.
- W2896800569 cites W1999859068 @default.
- W2896800569 cites W2002223395 @default.
- W2896800569 cites W2012096564 @default.
- W2896800569 cites W2012650501 @default.
- W2896800569 cites W2020445250 @default.
- W2896800569 cites W2021992969 @default.
- W2896800569 cites W2025322481 @default.
- W2896800569 cites W2026406649 @default.
- W2896800569 cites W2027257508 @default.
- W2896800569 cites W2027763741 @default.
- W2896800569 cites W2034825035 @default.
- W2896800569 cites W2053105417 @default.
- W2896800569 cites W2058667120 @default.
- W2896800569 cites W2066200788 @default.
- W2896800569 cites W2080832433 @default.
- W2896800569 cites W2080956060 @default.
- W2896800569 cites W2085768803 @default.
- W2896800569 cites W2095936660 @default.
- W2896800569 cites W2096528264 @default.
- W2896800569 cites W2097313599 @default.
- W2896800569 cites W2100555931 @default.
- W2896800569 cites W2102844820 @default.
- W2896800569 cites W2107661454 @default.
- W2896800569 cites W2110153407 @default.
- W2896800569 cites W2112245559 @default.
- W2896800569 cites W2115236407 @default.
- W2896800569 cites W2118139844 @default.
- W2896800569 cites W2121466085 @default.
- W2896800569 cites W2122894295 @default.
- W2896800569 cites W2124648245 @default.
- W2896800569 cites W2128590024 @default.
- W2896800569 cites W2129585892 @default.
- W2896800569 cites W2139624389 @default.
- W2896800569 cites W2139915659 @default.
- W2896800569 cites W2140115764 @default.
- W2896800569 cites W2151834160 @default.
- W2896800569 cites W2153003425 @default.
- W2896800569 cites W2153282882 @default.
- W2896800569 cites W2153589742 @default.
- W2896800569 cites W2155441570 @default.
- W2896800569 cites W2160536058 @default.
- W2896800569 cites W2163435967 @default.
- W2896800569 cites W2165413853 @default.
- W2896800569 cites W2178378154 @default.
- W2896800569 cites W2181344063 @default.
- W2896800569 cites W2186418777 @default.
- W2896800569 cites W2228917354 @default.
- W2896800569 cites W2238707848 @default.
- W2896800569 cites W2257508508 @default.
- W2896800569 cites W2265634200 @default.
- W2896800569 cites W2269343312 @default.
- W2896800569 cites W2272597365 @default.
- W2896800569 cites W2291123596 @default.
- W2896800569 cites W2303701034 @default.
- W2896800569 cites W2341550951 @default.
- W2896800569 cites W2342100485 @default.
- W2896800569 cites W2342971458 @default.
- W2896800569 cites W2407451224 @default.
- W2896800569 cites W2418575920 @default.
- W2896800569 cites W2418627758 @default.
- W2896800569 cites W2510391108 @default.
- W2896800569 cites W2514335655 @default.
- W2896800569 cites W2523566009 @default.
- W2896800569 cites W2544485223 @default.
- W2896800569 cites W2561869874 @default.
- W2896800569 cites W2593205529 @default.
- W2896800569 cites W2608920382 @default.
- W2896800569 cites W2610887355 @default.
- W2896800569 cites W2617005810 @default.
- W2896800569 cites W2623396617 @default.
- W2896800569 cites W2625789405 @default.
- W2896800569 cites W2725988230 @default.
- W2896800569 cites W2726084609 @default.
- W2896800569 cites W2735598012 @default.