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- W2896801201 abstract "Alzheimer's disease (AD) prevalence is expected to triple by 2050, and current medications do not change the disease course. Recent studies have projected that up to 30% of AD and other dementias may be preventable by targeting modifiable risk factors. Yet, multi-domain interventions aimed at reducing risk factors for dementia have not been well studied (especially in the US) and rarely with a personalized approach. We present the protocol for a new NIH-funded pilot trial designed to assess the effect of personalized risk factor modification on 2-year cognitive decline among members of an integrated health care delivery system. The Systematic Multidomain Alzheimer's Risk Reduction Trial (SMARRT) is a 2-year pilot trial designed to compare a personalized risk reduction intervention to usual care among 200 at risk older adults without dementia. Intervention participants will receive a personalized team-based (e.g. health coach, nurse) program with contacts by phone and in person. Key components are tailored risk assessments, personalized action plans, and content addressing various risk factors including poor hypertension and diabetes control; smoking; physical inactivity; depression; social isolation; diet; poor sleep quality and high risk medications. The control group will receive health education materials over the 2-year period. We have developed a novel personalized multi-domain risk reduction intervention to reduce AD risk and slow cognitive decline in an integrated healthcare delivery setting. An in-depth protocol has been developed to conduct this novel trial. An operations manual and intervention modules have been designed, and a DSMB has been convened. The primary outcome of the trial will be cognitive test performance; secondary outcomes will include risk reduction, quality of life, functional status, and incident mild cognitive impairment. The results will provide insight into key dementia risk reduction strategies and their effects on cognitive decline among older adults at increased risk for dementia and lay the groundwork for large scale roll-out of this intervention." @default.
- W2896801201 created "2018-10-26" @default.
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- W2896801201 date "2018-07-01" @default.
- W2896801201 modified "2023-10-16" @default.
- W2896801201 title "P4‐180: THE RATIONALE AND PROTOCOL FOR THE SYSTEMATIC MULTIDOMAIN ALZHEIMER'S RISK REDUCTION TRIAL (SMARRT)" @default.
- W2896801201 doi "https://doi.org/10.1016/j.jalz.2018.06.2585" @default.
- W2896801201 hasPublicationYear "2018" @default.
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