FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896801306> ?p ?o ?g. }

• W2896801306 abstract "We previously demonstrated that a cerebral white matter reference region could improve the ability of longitudinal florbetapir standard uptake value (SUV) ratios (SUVR) to track changes in amyloid-β (Aβ) levels (Chen et al., 2015). Here we sought to compare white matter to two candidate reference regions to test their the ability to detect Aβ elevations and associations with age and memory decline with cross-sectional florbetapir SUVRs in Presenilin (PSEN1) E280A mutation carriers from the Colombian Autosomal Dominant Alzheimer's Disease (ADAD) kindred. Cerebral white matter (corpus callosum[CC], centrum semi-ovale[CSO], and combined[WM]), cerebellar, and pontine reference regions were used to compute cerebral-to-reference region SUVRs using florbetapir PET scans acquired as reported (Fleisher et al., 2012). Nineteen cognitively unimpaired mutation carriers (mean age=32), 11 impaired mutation carriers (mean age=47), and 20 age-matched non-carriers of the PSEN1 mutation were included in the analyses. We compared the ability of different reference regions to detect elevated SUVRs and characterize associations with age and memory performance in the carrier group. Finally, since deceased mutation carriers with cognitive impairment are known to have neuropathological evidence of Aβ burden in the cerebellum, we compared reference region SUVs between our three groups. There were significant between-group SUVR differences (impaired carriers>unimpaired carriers>non-carriers) using each of the five reference regions. All reference regions similarly detected elevated levels of Aβ, and showed significant associations of SUVRs with age and worse memory performance in mutation carriers. However, associations with memory performance were stronger when using CC (p=0.02), CSO (p=.002), and WM reference regions (p=.06) compared to pontine. In comparison with impaired mutation carriers and non-carriers, SUVs were significantly greater in impaired mutation carriers in the cerebellar region, but not in white matter or pontine regions. Use of a white matter reference region may increase the ability to characterize cross-sectional florbetapir PET measurements of Aβ burden in ADAD mutation carriers, aid in identifying individuals at preclinical stages, and better inform future clinical trials. While our previously employed pontine reference region may be an acceptable alternative, a cerebellar reference region may be confounded by Aβ burden in the clinical stages of ADAD." @default.
• W2896801306 created "2018-10-26" @default.
• W2896801306 creator A5002451678 @default.
• W2896801306 creator A5003866262 @default.
• W2896801306 creator A5004794322 @default.
• W2896801306 creator A5024744959 @default.
• W2896801306 creator A5026950221 @default.
• W2896801306 creator A5027820710 @default.
• W2896801306 creator A5047768726 @default.
• W2896801306 creator A5055843167 @default.
• W2896801306 creator A5063895877 @default.
• W2896801306 creator A5073489682 @default.
• W2896801306 date "2018-07-01" @default.
• W2896801306 modified "2023-10-16" @default.
• W2896801306 title "IC‐P‐010: COMPARING CEREBRAL WHITE MATTER, CEREBELLAR, AND PONTINE REFERENCE REGIONS TO CHARACTERIZE FLORBETAPIR PET MEASUREMENTS OF AMYLOID‐β BURDEN IN PSEN1 E280A MUTATION CARRIERS AND NONCARRIERS FROM THE COLOMBIAN AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE KINDRED" @default.
• W2896801306 doi "https://doi.org/10.1016/j.jalz.2018.06.2074" @default.
• W2896801306 hasPublicationYear "2018" @default.
• W2896801306 type Work @default.
• W2896801306 sameAs 2896801306 @default.
• W2896801306 citedByCount "0" @default.
• W2896801306 crossrefType "journal-article" @default.
• W2896801306 hasAuthorship W2896801306A5002451678 @default.
• W2896801306 hasAuthorship W2896801306A5003866262 @default.
• W2896801306 hasAuthorship W2896801306A5004794322 @default.
• W2896801306 hasAuthorship W2896801306A5024744959 @default.
• W2896801306 hasAuthorship W2896801306A5026950221 @default.
• W2896801306 hasAuthorship W2896801306A5027820710 @default.
• W2896801306 hasAuthorship W2896801306A5047768726 @default.
• W2896801306 hasAuthorship W2896801306A5055843167 @default.
• W2896801306 hasAuthorship W2896801306A5063895877 @default.
• W2896801306 hasAuthorship W2896801306A5073489682 @default.
• W2896801306 hasConcept C126838900 @default.
• W2896801306 hasConcept C142724271 @default.
• W2896801306 hasConcept C143409427 @default.
• W2896801306 hasConcept C15744967 @default.
• W2896801306 hasConcept C169760540 @default.
• W2896801306 hasConcept C175344181 @default.
• W2896801306 hasConcept C2776485563 @default.
• W2896801306 hasConcept C2779134260 @default.
• W2896801306 hasConcept C2779652256 @default.
• W2896801306 hasConcept C2781192897 @default.
• W2896801306 hasConcept C502032728 @default.
• W2896801306 hasConcept C71924100 @default.
• W2896801306 hasConceptScore W2896801306C126838900 @default.
• W2896801306 hasConceptScore W2896801306C142724271 @default.
• W2896801306 hasConceptScore W2896801306C143409427 @default.
• W2896801306 hasConceptScore W2896801306C15744967 @default.
• W2896801306 hasConceptScore W2896801306C169760540 @default.
• W2896801306 hasConceptScore W2896801306C175344181 @default.
• W2896801306 hasConceptScore W2896801306C2776485563 @default.
• W2896801306 hasConceptScore W2896801306C2779134260 @default.
• W2896801306 hasConceptScore W2896801306C2779652256 @default.
• W2896801306 hasConceptScore W2896801306C2781192897 @default.
• W2896801306 hasConceptScore W2896801306C502032728 @default.
• W2896801306 hasConceptScore W2896801306C71924100 @default.
• W2896801306 hasIssue "7S_Part_1" @default.
• W2896801306 hasLocation W28968013061 @default.
• W2896801306 hasOpenAccess W2896801306 @default.
• W2896801306 hasPrimaryLocation W28968013061 @default.
• W2896801306 hasRelatedWork W1977100803 @default.
• W2896801306 hasRelatedWork W2001854231 @default.
• W2896801306 hasRelatedWork W2024024756 @default.
• W2896801306 hasRelatedWork W2133132878 @default.
• W2896801306 hasRelatedWork W2151288930 @default.
• W2896801306 hasRelatedWork W2169313980 @default.
• W2896801306 hasRelatedWork W2416462336 @default.
• W2896801306 hasRelatedWork W2766902548 @default.
• W2896801306 hasRelatedWork W2801312068 @default.
• W2896801306 hasRelatedWork W2950273610 @default.
• W2896801306 hasVolume "14" @default.
• W2896801306 isParatext "false" @default.
• W2896801306 isRetracted "false" @default.
• W2896801306 magId "2896801306" @default.
• W2896801306 workType "article" @default.