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• W2896810436 abstract "Abstract Background Stem cell transplantation (SCT) outcomes have improved over the last three decades, with many patients being rescued with this treatment. However, improved outcomes have led to issues with long‐term sequelae. One of these sequelae in children is renal dysfunction, an index of which is estimated using glomerular filtration rate (eGFR). Procedure We retrospectively analyzed eGFR in 83 pediatric patients who received SCT. Data from all patients extended up to 12 months or more post SCT. The median follow‐up time was 127.7 months (range 12.0‐268.8 months). Results Eighteen patients (21.7%) had low eGFR (<90 ml/min/1.73 m 2 ) post SCT. Cumulative incidence of low eGFR was 25.8 ± 2.0%. Nine (10.6%) patients had a low eGFR pre‐SCT. However, pre‐ and post‐SCT incidence of low eGFR were not correlated. Meanwhile, only two patients (2.4%) exhibited severe renal dysfunction, with eGFRs < 60 ml/min/1.73 m 2 . Independent risk factors for low eGFR were solid tumor and use of fludarabine. Moreover, age at SCT ≥ 7 years was also a long‐term post‐SCT risk factor for low eGFR in all patients. Conclusion Independent post‐SCT long‐term risk factors for low eGFR in children were solid tumor and use of fludarabine. Moreover, age at SCT ≥ 7 years was a post‐SCT long‐term risk factor for low eGFR across all patients." @default.
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• W2896810436 date "2018-10-23" @default.
• W2896810436 modified "2023-10-18" @default.
• W2896810436 title "Long-term outcome of renal function in children after stem cell transplantation measured by estimated glomerular filtration rate" @default.
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• W2896810436 doi "https://doi.org/10.1002/pbc.27478" @default.
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