Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896811518> ?p ?o ?g. }
- W2896811518 endingPage "929" @default.
- W2896811518 startingPage "915" @default.
- W2896811518 abstract "Cancer survivors often carry disseminated tumour cells (DTCs), yet owing to DTC dormancy they do not relapse from treatment. Understanding how the local microenvironment regulates the transition of DTCs from a quiescent state to active proliferation could suggest new therapeutic strategies to prevent or delay the formation of metastases. Here, we show that implantable biomaterial microenvironments incorporating human stromal cells, immune cells and cancer cells can be used to examine the post-dissemination phase of the evolution of the tumour microenvironment. After subdermal implantation in mice, porous hydrogel scaffolds seeded with human bone marrow stromal cells form a vascularized niche and recruit human circulating tumour cells released from an orthotopic prostate tumour xenograft. Systemic injection of human peripheral blood mononuclear cells slowed the evolution of the active metastatic niches but did not change the rate of overt metastases, as the ensuing inflammation promoted the formation of DTC colonies. Implantable pre-metastatic niches might enable the study of DTC colonization and proliferation, and facilitate the development of effective anti-metastatic therapies." @default.
- W2896811518 created "2018-10-26" @default.
- W2896811518 creator A5001871093 @default.
- W2896811518 creator A5008075748 @default.
- W2896811518 creator A5018902190 @default.
- W2896811518 creator A5051251433 @default.
- W2896811518 date "2018-10-22" @default.
- W2896811518 modified "2023-10-16" @default.
- W2896811518 title "Implantable pre-metastatic niches for the study of the microenvironmental regulation of disseminated human tumour cells" @default.
- W2896811518 cites W1132419313 @default.
- W2896811518 cites W1159905982 @default.
- W2896811518 cites W1482515349 @default.
- W2896811518 cites W1494987922 @default.
- W2896811518 cites W1495945591 @default.
- W2896811518 cites W1564674105 @default.
- W2896811518 cites W1572028736 @default.
- W2896811518 cites W1601681275 @default.
- W2896811518 cites W1851720544 @default.
- W2896811518 cites W1854274831 @default.
- W2896811518 cites W1963979299 @default.
- W2896811518 cites W1966560779 @default.
- W2896811518 cites W1966705755 @default.
- W2896811518 cites W1971012944 @default.
- W2896811518 cites W1971416592 @default.
- W2896811518 cites W1975604213 @default.
- W2896811518 cites W1980471134 @default.
- W2896811518 cites W1981421409 @default.
- W2896811518 cites W1983701552 @default.
- W2896811518 cites W1984736888 @default.
- W2896811518 cites W1985727076 @default.
- W2896811518 cites W1993497779 @default.
- W2896811518 cites W1999356404 @default.
- W2896811518 cites W2001868807 @default.
- W2896811518 cites W2002355437 @default.
- W2896811518 cites W2005506639 @default.
- W2896811518 cites W2006122359 @default.
- W2896811518 cites W2006960578 @default.
- W2896811518 cites W2006986876 @default.
- W2896811518 cites W2007667352 @default.
- W2896811518 cites W2007897263 @default.
- W2896811518 cites W2030446285 @default.
- W2896811518 cites W2031991121 @default.
- W2896811518 cites W2032386695 @default.
- W2896811518 cites W2035953137 @default.
- W2896811518 cites W2037133813 @default.
- W2896811518 cites W2037225246 @default.
- W2896811518 cites W2042782160 @default.
- W2896811518 cites W2043156676 @default.
- W2896811518 cites W2043166238 @default.
- W2896811518 cites W2044702943 @default.
- W2896811518 cites W2046161326 @default.
- W2896811518 cites W2049959255 @default.
- W2896811518 cites W2052294965 @default.
- W2896811518 cites W2054017641 @default.
- W2896811518 cites W2057359010 @default.
- W2896811518 cites W2058648826 @default.
- W2896811518 cites W2059653502 @default.
- W2896811518 cites W2062253841 @default.
- W2896811518 cites W2062889582 @default.
- W2896811518 cites W2063725270 @default.
- W2896811518 cites W2069121320 @default.
- W2896811518 cites W2069749649 @default.
- W2896811518 cites W2073821065 @default.
- W2896811518 cites W2074469498 @default.
- W2896811518 cites W2076507262 @default.
- W2896811518 cites W2093679515 @default.
- W2896811518 cites W2097025530 @default.
- W2896811518 cites W2100303404 @default.
- W2896811518 cites W2100945326 @default.
- W2896811518 cites W2103919594 @default.
- W2896811518 cites W2106572080 @default.
- W2896811518 cites W2106738771 @default.
- W2896811518 cites W2108929503 @default.
- W2896811518 cites W2115900736 @default.
- W2896811518 cites W2117034501 @default.
- W2896811518 cites W2119560054 @default.
- W2896811518 cites W2127897152 @default.
- W2896811518 cites W2146530991 @default.
- W2896811518 cites W2148881715 @default.
- W2896811518 cites W2151840649 @default.
- W2896811518 cites W2151878529 @default.
- W2896811518 cites W2154706646 @default.
- W2896811518 cites W2155542819 @default.
- W2896811518 cites W2159744630 @default.
- W2896811518 cites W2163472474 @default.
- W2896811518 cites W2164918734 @default.
- W2896811518 cites W2169872175 @default.
- W2896811518 cites W2171298396 @default.
- W2896811518 cites W2193074466 @default.
- W2896811518 cites W2203076610 @default.
- W2896811518 cites W2218034730 @default.
- W2896811518 cites W2220756562 @default.
- W2896811518 cites W2263679062 @default.
- W2896811518 cites W2314203153 @default.
- W2896811518 cites W2328910605 @default.
- W2896811518 cites W2336302298 @default.
- W2896811518 cites W2336642884 @default.
- W2896811518 cites W2406237471 @default.