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• W2896814547 abstract "Background: We aimed to understand the way in which therapeutic drug monitoring (TDM) is used, understood and interpreted for anti-TNF agents in IBD.Research design and methods: We designed an 18-question survey that included 5 TDM-based clinical scenarios, for which the ‘most appropriate’ responses were based on the BRIDGe groups ‘Anti-TNF Optimizer’. This resource combines TDM evidence with expert consensus.Results: We received 110 complete responses: 50 (45%) consultants, 30 (27%) trainees, 25 (23%) IBD nurse specialists and 5 (5%) gastroenterology pharmacists. Over half (61, 55%) only carry out TDM in non-response. The remainder use TDM routinely, including during stable maintenance therapy for patients in remission. Lower therapeutic thresholds used were variable. Most (82, 75%) were unsure whether their laboratory uses a drug-tolerant or drug-sensitive antidrug antibody assay and few (15, 14%) understand the difference. Consultants, high-frequency users (> 3requests/month) and clinicians with larger anti-TNF cohorts (> 100) were significantly more likely to select the ‘most appropriate’ answer to at least 1 of the 5 TDM-based clinical scenarios.Conclusions: There exists marked heterogeneity in the practical use, understanding and interpretation of biologic TDM. Biologic decision-making, informed by TDM, should involve consultation with experienced clinicians who are frequent TDM users, ideally, as part of a multidisciplinary, biologics-focused IBD meeting.Abbreviations: TDM: therapeutic drug monitoring; CNS: clinical nurse specialist; ELISA: enzyme-linked immunosorbent assay; RIA: radioimmunoassays; HMSA: homogenous mobility shift assays; BSG: British Society of Gastroenterology." @default.
• W2896814547 created "2018-10-26" @default.
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• W2896814547 date "2018-10-24" @default.
• W2896814547 modified "2023-09-30" @default.
• W2896814547 title "Wide variation in the use and understanding of therapeutic drug monitoring for anti-TNF agents in inflammatory bowel disease: an inexact science?" @default.
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• W2896814547 doi "https://doi.org/10.1080/14712598.2018.1537367" @default.
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