Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896815360> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W2896815360 endingPage "229" @default.
- W2896815360 startingPage "228" @default.
- W2896815360 abstract "Spontaneous preterm birth with preterm delivery (before week 37) and other high prevalence pregnancy-associated diseases, including early-onset preeclampsia, late-onset preeclampsia, and fetal intrauterine growth restriction, form the “Big 4” of pregnancy complications. Until now, truly effective methods to screen, prevent, or manage these complications have been lacking. A major obstacle is the fact that many of these diseases have an early placental origin with late clinical presentation in the mother. Methods that allow presymptomatic screening or diagnosis are urgently needed to overcome the time disparities between disease origin and presentation for the benefit of the mothers and babies involved.In a recent issue of Science , Quake and colleagues have demonstrated 1 of the first prerequisites to reach this goal (1). Their approach was based on their previous work and that of another pioneering group in the field of noninvasive prenatal screening, both of which clearly showed the possibility of maternal plasma sequencing using circulating cell-free fetal nucleic acids. Applying this approach, they identified by maternal plasma RNA sequencing of 38 women (23 full-term and 15 preterm deliveries) that a set of 7 cell-free fetal RNA (cffRNA) transcripts permitted classification of women who delivered preterm up to 2 months in advance of labor (1, 2). Although these results certainly require validation in larger, blinded clinical trials, their proof of principle indicates the potential of the approach used and generates exciting new perspectives, both for preterm delivery and other diseases of the Big 4.A …" @default.
- W2896815360 created "2018-10-26" @default.
- W2896815360 creator A5034876492 @default.
- W2896815360 date "2019-02-01" @default.
- W2896815360 modified "2023-09-25" @default.
- W2896815360 title "Presymptomatic Noninvasive Assessment of Fetal Well-being by Genome-wide RNA Sequencing" @default.
- W2896815360 cites W2103193555 @default.
- W2896815360 cites W2157820287 @default.
- W2896815360 cites W2546698177 @default.
- W2896815360 cites W2805423673 @default.
- W2896815360 doi "https://doi.org/10.1373/clinchem.2018.294199" @default.
- W2896815360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30327300" @default.
- W2896815360 hasPublicationYear "2019" @default.
- W2896815360 type Work @default.
- W2896815360 sameAs 2896815360 @default.
- W2896815360 citedByCount "2" @default.
- W2896815360 countsByYear W28968153602020 @default.
- W2896815360 countsByYear W28968153602021 @default.
- W2896815360 crossrefType "journal-article" @default.
- W2896815360 hasAuthorship W2896815360A5034876492 @default.
- W2896815360 hasBestOaLocation W28968153601 @default.
- W2896815360 hasConcept C104317684 @default.
- W2896815360 hasConcept C141231307 @default.
- W2896815360 hasConcept C172680121 @default.
- W2896815360 hasConcept C2779234561 @default.
- W2896815360 hasConcept C54355233 @default.
- W2896815360 hasConcept C67705224 @default.
- W2896815360 hasConcept C70721500 @default.
- W2896815360 hasConcept C71924100 @default.
- W2896815360 hasConcept C86803240 @default.
- W2896815360 hasConceptScore W2896815360C104317684 @default.
- W2896815360 hasConceptScore W2896815360C141231307 @default.
- W2896815360 hasConceptScore W2896815360C172680121 @default.
- W2896815360 hasConceptScore W2896815360C2779234561 @default.
- W2896815360 hasConceptScore W2896815360C54355233 @default.
- W2896815360 hasConceptScore W2896815360C67705224 @default.
- W2896815360 hasConceptScore W2896815360C70721500 @default.
- W2896815360 hasConceptScore W2896815360C71924100 @default.
- W2896815360 hasConceptScore W2896815360C86803240 @default.
- W2896815360 hasIssue "2" @default.
- W2896815360 hasLocation W28968153601 @default.
- W2896815360 hasLocation W28968153602 @default.
- W2896815360 hasOpenAccess W2896815360 @default.
- W2896815360 hasPrimaryLocation W28968153601 @default.
- W2896815360 hasRelatedWork W1828691184 @default.
- W2896815360 hasRelatedWork W2002128513 @default.
- W2896815360 hasRelatedWork W2030640333 @default.
- W2896815360 hasRelatedWork W2080247180 @default.
- W2896815360 hasRelatedWork W2905474975 @default.
- W2896815360 hasRelatedWork W3037403499 @default.
- W2896815360 hasRelatedWork W3040132961 @default.
- W2896815360 hasRelatedWork W3187879072 @default.
- W2896815360 hasRelatedWork W4246102828 @default.
- W2896815360 hasRelatedWork W2092874662 @default.
- W2896815360 hasVolume "65" @default.
- W2896815360 isParatext "false" @default.
- W2896815360 isRetracted "false" @default.
- W2896815360 magId "2896815360" @default.
- W2896815360 workType "article" @default.