Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896819091> ?p ?o ?g. }
- W2896819091 endingPage "1803925" @default.
- W2896819091 startingPage "1803925" @default.
- W2896819091 abstract "The emergence of antimicrobial resistance poses a major challenge to healthcare. Probiotics offer a potential alternative treatment method but are often incompatible with antibiotics themselves, diminishing their overall therapeutic utility. This work uses biofilm-inspired encapsulation of probiotics to confer temporary antibiotic protection and to enable the coadministration of probiotics and antibiotics. Probiotics are encapsulated within alginate, a crucial component of pseudomonas biofilms, based on a simple two-step alginate cross-linking procedure. Following exposure to the antibiotic tobramycin, the growth and metabolic activity of encapsulated probiotics are unaffected by tobramycin, and they show a four-log survival advantage over free probiotics. This results from tobramycin sequestration on the periphery of alginate beads which prevents its diffusion into the core but yet allows probiotic byproducts to diffuse outward. It is demonstrated that this approach using tobramycin combined with encapsulated probiotic has the ability to completely eradicate methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa in coculture, the two most widely implicated bacteria in chronic wounds." @default.
- W2896819091 created "2018-10-26" @default.
- W2896819091 creator A5003451952 @default.
- W2896819091 creator A5025999852 @default.
- W2896819091 creator A5027428798 @default.
- W2896819091 creator A5039974064 @default.
- W2896819091 creator A5042597057 @default.
- W2896819091 creator A5053332014 @default.
- W2896819091 creator A5065264754 @default.
- W2896819091 creator A5069229817 @default.
- W2896819091 date "2018-10-17" @default.
- W2896819091 modified "2023-10-03" @default.
- W2896819091 title "Biofilm-Inspired Encapsulation of Probiotics for the Treatment of Complex Infections" @default.
- W2896819091 cites W1851197753 @default.
- W2896819091 cites W1965006954 @default.
- W2896819091 cites W1969179300 @default.
- W2896819091 cites W1971500643 @default.
- W2896819091 cites W1979973356 @default.
- W2896819091 cites W1988161935 @default.
- W2896819091 cites W1996224430 @default.
- W2896819091 cites W1996344389 @default.
- W2896819091 cites W2006521319 @default.
- W2896819091 cites W2007331931 @default.
- W2896819091 cites W2010360751 @default.
- W2896819091 cites W2018359273 @default.
- W2896819091 cites W2039983286 @default.
- W2896819091 cites W2047160440 @default.
- W2896819091 cites W2051756303 @default.
- W2896819091 cites W2057213586 @default.
- W2896819091 cites W2060093568 @default.
- W2896819091 cites W2072888501 @default.
- W2896819091 cites W2073395843 @default.
- W2896819091 cites W2078606044 @default.
- W2896819091 cites W2078681628 @default.
- W2896819091 cites W2082405022 @default.
- W2896819091 cites W2091651320 @default.
- W2896819091 cites W2097808005 @default.
- W2896819091 cites W2101425232 @default.
- W2896819091 cites W2101830519 @default.
- W2896819091 cites W2102677849 @default.
- W2896819091 cites W2106800710 @default.
- W2896819091 cites W2108127896 @default.
- W2896819091 cites W2108530765 @default.
- W2896819091 cites W2114923501 @default.
- W2896819091 cites W2115486016 @default.
- W2896819091 cites W2126221953 @default.
- W2896819091 cites W2147038478 @default.
- W2896819091 cites W2155572331 @default.
- W2896819091 cites W2158709371 @default.
- W2896819091 cites W2160311975 @default.
- W2896819091 cites W2169023315 @default.
- W2896819091 cites W2260141621 @default.
- W2896819091 cites W2727909168 @default.
- W2896819091 cites W2800799562 @default.
- W2896819091 cites W4211210519 @default.
- W2896819091 cites W4245920351 @default.
- W2896819091 doi "https://doi.org/10.1002/adma.201803925" @default.
- W2896819091 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30328144" @default.
- W2896819091 hasPublicationYear "2018" @default.
- W2896819091 type Work @default.
- W2896819091 sameAs 2896819091 @default.
- W2896819091 citedByCount "88" @default.
- W2896819091 countsByYear W28968190912019 @default.
- W2896819091 countsByYear W28968190912020 @default.
- W2896819091 countsByYear W28968190912021 @default.
- W2896819091 countsByYear W28968190912022 @default.
- W2896819091 countsByYear W28968190912023 @default.
- W2896819091 crossrefType "journal-article" @default.
- W2896819091 hasAuthorship W2896819091A5003451952 @default.
- W2896819091 hasAuthorship W2896819091A5025999852 @default.
- W2896819091 hasAuthorship W2896819091A5027428798 @default.
- W2896819091 hasAuthorship W2896819091A5039974064 @default.
- W2896819091 hasAuthorship W2896819091A5042597057 @default.
- W2896819091 hasAuthorship W2896819091A5053332014 @default.
- W2896819091 hasAuthorship W2896819091A5065264754 @default.
- W2896819091 hasAuthorship W2896819091A5069229817 @default.
- W2896819091 hasBestOaLocation W28968190912 @default.
- W2896819091 hasConcept C2775832221 @default.
- W2896819091 hasConcept C2777637488 @default.
- W2896819091 hasConcept C2778974779 @default.
- W2896819091 hasConcept C2779489039 @default.
- W2896819091 hasConcept C2780255968 @default.
- W2896819091 hasConcept C2781463711 @default.
- W2896819091 hasConcept C4937899 @default.
- W2896819091 hasConcept C501593827 @default.
- W2896819091 hasConcept C523546767 @default.
- W2896819091 hasConcept C54355233 @default.
- W2896819091 hasConcept C58123911 @default.
- W2896819091 hasConcept C86803240 @default.
- W2896819091 hasConcept C89423630 @default.
- W2896819091 hasConceptScore W2896819091C2775832221 @default.
- W2896819091 hasConceptScore W2896819091C2777637488 @default.
- W2896819091 hasConceptScore W2896819091C2778974779 @default.
- W2896819091 hasConceptScore W2896819091C2779489039 @default.
- W2896819091 hasConceptScore W2896819091C2780255968 @default.
- W2896819091 hasConceptScore W2896819091C2781463711 @default.
- W2896819091 hasConceptScore W2896819091C4937899 @default.
- W2896819091 hasConceptScore W2896819091C501593827 @default.