FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896824926> ?p ?o ?g. }

• W2896824926 abstract "Fibroblast activation is a key step in the establishment of skin fibrosis induced by acute injury, and it is characterized by the differentiation of plastic resident tissue fibroblasts into contractile, extracellular matrix‑secreting myofibroblasts. As fibroblast activation must be regulated in vivo, fibroblasts receive signals from the surrounding environment that initiate their fibrotic program. Thus, the present study investigated the effects of mitogen‑activated protein kinase (MAPK) signaling pathways on fibroblast activation. It was demonstrated in primary human dermal fibroblasts that small molecule‑mediated inhibition of extracellular signal‑regulated kinase (ERK) and c‑Jun N‑terminal kinase (JNK) potentiated fibroblast activation, and that small molecule‑mediated inhibition of p38 antagonized fibroblast activation. ERK and JNK inhibition cooperatively enhanced fibroblast activation mediated by treatment with exogenous transforming growth factor (TGF)‑β1, and p38 inhibition antagonized ERK inhibitor‑mediated or JNK inhibitor‑mediated fibroblast activation. Transcript analysis demonstrated that ERK and JNK inhibitor‑mediated fibroblast activation was accompanied by distinct changes in the expression of TGF‑β‑associated ligands and receptors, and that p38 inhibitor‑mediated antagonism of fibroblast activation was accompanied by a distinct expression paradigm of TGF‑β‑associated genes, including upregulation of betaglycan. ERK inhibitor‑mediated and JNK inhibitor‑mediated fibroblast activation was partially antagonized by small molecule‑mediated inhibition of TGF‑β receptor (R)1, indicating that these mechanisms of fibroblast activation are partially dependent on TGF‑β/TGF‑βR signaling. These data collectively demonstrate and provide partial explanations of the varied effects and pathway dependencies of MAPK inhibitor‑mediated effects on fibroblast activation." @default.
• W2896824926 created "2018-10-26" @default.
• W2896824926 creator A5058058752 @default.
• W2896824926 creator A5059430272 @default.
• W2896824926 creator A5088250651 @default.
• W2896824926 date "2018-10-23" @default.
• W2896824926 modified "2023-09-27" @default.
• W2896824926 title "Crosstalk between mitogen-activated protein kinase inhibitors and transforming growth factor-β signaling results in variable activation of human dermal fibroblasts" @default.
• W2896824926 cites W1517079251 @default.
• W2896824926 cites W1931315964 @default.
• W2896824926 cites W1949832432 @default.
• W2896824926 cites W1965605768 @default.
• W2896824926 cites W1978785485 @default.
• W2896824926 cites W1981269419 @default.
• W2896824926 cites W1983765056 @default.
• W2896824926 cites W1986753065 @default.
• W2896824926 cites W1986963447 @default.
• W2896824926 cites W1988476050 @default.
• W2896824926 cites W1996621568 @default.
• W2896824926 cites W2003809526 @default.
• W2896824926 cites W2008374414 @default.
• W2896824926 cites W2018453308 @default.
• W2896824926 cites W2018998090 @default.
• W2896824926 cites W2024623214 @default.
• W2896824926 cites W2030366802 @default.
• W2896824926 cites W2031334428 @default.
• W2896824926 cites W2032307233 @default.
• W2896824926 cites W2037942851 @default.
• W2896824926 cites W2039133374 @default.
• W2896824926 cites W2044812837 @default.
• W2896824926 cites W2046822015 @default.
• W2896824926 cites W2049530394 @default.
• W2896824926 cites W2057539625 @default.
• W2896824926 cites W2069911905 @default.
• W2896824926 cites W2070702664 @default.
• W2896824926 cites W2071202484 @default.
• W2896824926 cites W2082408176 @default.
• W2896824926 cites W2097202285 @default.
• W2896824926 cites W2100044667 @default.
• W2896824926 cites W2103484049 @default.
• W2896824926 cites W2107495112 @default.
• W2896824926 cites W2109143007 @default.
• W2896824926 cites W2112099875 @default.
• W2896824926 cites W2114570899 @default.
• W2896824926 cites W2116261308 @default.
• W2896824926 cites W2123989622 @default.
• W2896824926 cites W2127042315 @default.
• W2896824926 cites W2129303004 @default.
• W2896824926 cites W2133850870 @default.
• W2896824926 cites W2134931198 @default.
• W2896824926 cites W2136213916 @default.
• W2896824926 cites W2150019943 @default.
• W2896824926 cites W2156436523 @default.
• W2896824926 cites W2159267519 @default.
• W2896824926 cites W2159664830 @default.
• W2896824926 cites W2161186807 @default.
• W2896824926 cites W2171177609 @default.
• W2896824926 cites W2199699123 @default.
• W2896824926 cites W2318349718 @default.
• W2896824926 cites W2476931074 @default.
• W2896824926 cites W2537569701 @default.
• W2896824926 cites W2597639984 @default.
• W2896824926 cites W2750719762 @default.
• W2896824926 cites W2768102825 @default.
• W2896824926 cites W4211100931 @default.
• W2896824926 cites W4253918859 @default.
• W2896824926 cites W2166064381 @default.
• W2896824926 doi "https://doi.org/10.3892/ijmm.2018.3949" @default.
• W2896824926 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6257852" @default.
• W2896824926 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30365043" @default.
• W2896824926 hasPublicationYear "2018" @default.
• W2896824926 type Work @default.
• W2896824926 sameAs 2896824926 @default.
• W2896824926 citedByCount "14" @default.
• W2896824926 countsByYear W28968249262019 @default.
• W2896824926 countsByYear W28968249262020 @default.
• W2896824926 countsByYear W28968249262021 @default.
• W2896824926 countsByYear W28968249262022 @default.
• W2896824926 countsByYear W28968249262023 @default.
• W2896824926 crossrefType "journal-article" @default.
• W2896824926 hasAuthorship W2896824926A5058058752 @default.
• W2896824926 hasAuthorship W2896824926A5059430272 @default.
• W2896824926 hasAuthorship W2896824926A5088250651 @default.
• W2896824926 hasBestOaLocation W28968249261 @default.
• W2896824926 hasConcept C111798993 @default.
• W2896824926 hasConcept C121608353 @default.
• W2896824926 hasConcept C132149769 @default.
• W2896824926 hasConcept C170493617 @default.
• W2896824926 hasConcept C184235292 @default.
• W2896824926 hasConcept C185592680 @default.
• W2896824926 hasConcept C202751555 @default.
• W2896824926 hasConcept C2778005187 @default.
• W2896824926 hasConcept C2780381497 @default.
• W2896824926 hasConcept C2781249067 @default.
• W2896824926 hasConcept C502942594 @default.
• W2896824926 hasConcept C54355233 @default.
• W2896824926 hasConcept C55493867 @default.
• W2896824926 hasConcept C57074206 @default.
• W2896824926 hasConcept C62478195 @default.
• W2896824926 hasConcept C74373430 @default.

• next