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• W2896827002 abstract "Preeclampsia (PE) is a common cause of maternal morbidity, characterized by impaired trophoblast invasion and spiral artery transformation resulting in progressive uteroplacental hypoxia. Given the primary role of LIN28A and LIN28B in modulating cell metabolism, differentiation, and invasion, we hypothesized that LIN28A and/or LIN28B regulates trophoblast differentiation and invasion, and that its dysregulation may contribute to PE. Here we show that LIN28B is expressed ∼1300-fold higher than LIN28A in human term placenta and is the predominant paralog expressed in primary human trophoblast cultures. The expression of LIN28B mRNA and protein levels are significantly reduced in gestational age-matched preeclamptic vs. normal placentas, whereas LIN28A expression is not different. First trimester human placental sections displayed stronger LIN28B immunoreactivity in extravillous (invasive) cytotrophoblasts and syncytial sprouts vs. villous trophoblasts. LIN28B overexpression increased HTR8 cell proliferation, migration, and invasion, whereas LIN28B knockdown in JEG3 cells reduced cell proliferation. Moreover, LIN28B knockdown in JEG3 cells suppressed syncytin 1 (SYN-1), apelin receptor early endogenous ligand (ELABELA), and the chromosome 19 microRNA cluster, and increased mRNA expression of ITGβ4 and TNF-α. Incubation of BeWo and JEG3 cells under hypoxia significantly decreased expression of LIN28B and LIN28A, SYN-1, and ELABELA, whereas TNF-α is increased. These results provide the first evidence that LIN28B is the predominant paralog in human placenta and that decreased LIN28B may play a role in PE by reducing trophoblast invasion and syncytialization, and by promoting inflammation.-Canfield, J., Arlier, S., Mong, E. F., Lockhart, J., VanWye, J., Guzeloglu-Kayisli, O., Schatz, F., Magness, R. R., Lockwood, C. J., Tsibris, J. C. M., Kayisli, U. A., Totary-Jain, H. Decreased LIN28B in preeclampsia impairs human trophoblast differentiation and migration." @default.
• W2896827002 created "2018-10-26" @default.
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• W2896827002 date "2018-10-11" @default.
• W2896827002 modified "2023-10-14" @default.
• W2896827002 title "Decreased LIN28B in preeclampsia impairs human trophoblast differentiation and migration" @default.
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• W2896827002 cites W1897059645 @default.
• W2896827002 cites W1931261640 @default.
• W2896827002 cites W1969150485 @default.
• W2896827002 cites W1976888700 @default.
• W2896827002 cites W1976968454 @default.
• W2896827002 cites W1981190999 @default.
• W2896827002 cites W1982163838 @default.
• W2896827002 cites W1984497969 @default.
• W2896827002 cites W1984970610 @default.
• W2896827002 cites W1988061615 @default.
• W2896827002 cites W1988194907 @default.
• W2896827002 cites W1992551111 @default.
• W2896827002 cites W1998393441 @default.
• W2896827002 cites W2005449334 @default.
• W2896827002 cites W2011993406 @default.
• W2896827002 cites W2012591837 @default.
• W2896827002 cites W2014444101 @default.
• W2896827002 cites W2014894250 @default.
• W2896827002 cites W2018619975 @default.
• W2896827002 cites W2021704352 @default.
• W2896827002 cites W2022674234 @default.
• W2896827002 cites W2023372666 @default.
• W2896827002 cites W2028963449 @default.
• W2896827002 cites W2033000623 @default.
• W2896827002 cites W2034806022 @default.
• W2896827002 cites W2037786477 @default.
• W2896827002 cites W2037885071 @default.
• W2896827002 cites W2038732152 @default.
• W2896827002 cites W2041865329 @default.
• W2896827002 cites W2048321373 @default.
• W2896827002 cites W2048691299 @default.
• W2896827002 cites W2059516008 @default.
• W2896827002 cites W2062723127 @default.
• W2896827002 cites W2066775630 @default.
• W2896827002 cites W2079023822 @default.
• W2896827002 cites W2105698711 @default.
• W2896827002 cites W2113111145 @default.
• W2896827002 cites W2114116986 @default.
• W2896827002 cites W2119043639 @default.
• W2896827002 cites W2135518377 @default.
• W2896827002 cites W2136952545 @default.
• W2896827002 cites W2141642891 @default.
• W2896827002 cites W2147088778 @default.
• W2896827002 cites W2147835141 @default.
• W2896827002 cites W2149323323 @default.
• W2896827002 cites W2150949422 @default.
• W2896827002 cites W2172157901 @default.
• W2896827002 cites W2203521782 @default.
• W2896827002 cites W2254887604 @default.
• W2896827002 cites W2260922547 @default.
• W2896827002 cites W2299735754 @default.
• W2896827002 cites W2314149200 @default.
• W2896827002 cites W2531493801 @default.
• W2896827002 cites W2557302241 @default.
• W2896827002 cites W2563522092 @default.
• W2896827002 cites W2587092965 @default.
• W2896827002 cites W2591249655 @default.
• W2896827002 cites W2593467526 @default.
• W2896827002 cites W2597435890 @default.
• W2896827002 cites W2608579198 @default.
• W2896827002 cites W2728308062 @default.
• W2896827002 cites W2740928018 @default.
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• W2896827002 cites W2783500032 @default.
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• W2896827002 doi "https://doi.org/10.1096/fj.201801163r" @default.
• W2896827002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6338627" @default.
• W2896827002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30307771" @default.
• W2896827002 hasPublicationYear "2018" @default.
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