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- W2896828006 abstract "Amyloid-β (Aβ) aggregation is a key early step in Alzheimer's disease (AD) pathogenesis and is followed by tau aggregation with spreading to neocortex, neuronal and synaptic loss, and cognitive impairment. A major goal of the field is to identify the transition from Aβ deposition without evidence of neuronal injury to the early stages of tauopathy when neuronal loss and then cognitive deficits begin to develop. Other than clinical signs and symptoms of cognitive decline, we currently have few other biomarkers of brain function that change with disease progression. Objective measures of sleep associated with AD pathology may provide a novel way to assess the transition from preclinical to symptomatic AD as well as to serve as a functional marker of disease progression. 40 participants (30 CDR 0, 10 CDR 0.5) underwent standardized cognitive assessments, 6 nights of home sleep monitoring from a single-channel EEG device (Sleep Profiler, Advanced Brain Monitoring, Carlsbad, CA) that records from the forehead, 1 night of an Alice PDX home sleep apnea test (Respironics, Bend, OR), and both amyloid (AV45) and tau (T807) PET imaging. We have shown that the single-channel EEG provides comparable results to polysomnography for assessing multiple sleep parameters, including NREM slow wave activity (SWA). After controlling for multiple factors that may alter sleep and AD pathology (age, sex, race, ApoE4 status, apnea-hypopnea index, and Clinical Dementia Rating score), 1-4.5 Hz NREM SWA showed a negative correlation to tau PET (r=-0.351, p=0.042). This association was due to 1-2 Hz frequencies (r=-0.396, p=0.021), rather than 2-3 Hz (r=-0.267, p=0.127) or 3-4 Hz (r=-0.167, p=0.344). We also found that amyloid PET and NREM SWA were not significantly correlated (p>0.05). Our findings show that increasing tauopathy is associated with lower all night SWA, particularly in the lowest 1-2 Hz frequencies. NREM SWA was not correlated with amyloid deposition. Previous research in humans reported that Aβ accumulation correlated with decreased NREM slow wave activity (SWA). In animal models, however, increased tauopathy was associated with decreased NREM SWA. Longitudinal studies are needed to establish the sequential links for changes in NREM SWA and AD pathology." @default.
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- W2896828006 date "2018-07-01" @default.
- W2896828006 modified "2023-10-16" @default.
- W2896828006 title "F4‐05‐03: ASSOCIATION OF AD PATHOLOGY AND NON‐RAPID EYE MOVEMENT SLOW WAVE ACTIVITY" @default.
- W2896828006 doi "https://doi.org/10.1016/j.jalz.2018.06.2882" @default.
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