Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896829480> ?p ?o ?g. }
- W2896829480 endingPage "257" @default.
- W2896829480 startingPage "247" @default.
- W2896829480 abstract "We compared the effects of single intraveinous injection of pituitary adenylate cyclase-activating polypeptide-38 (P38) to those of its analog, acetyl-[Ala15, Ala20]PACAP-38-propylamide (P38-alg) on spatial memory in the Morris water maze (MWM) using a weak massed-learning procedure, post-training brain derived neurotrophic factor (BDNF) and post-training oxidative stress biomarker assays in male Wistar rats. Acquisition of the MWM task following P38 (30 μg/kg) and P38-alg (30 μg/kg) treatments was similar to control group (Saline: 0.9% NaCl) and there was no interaction between treatments and performance. However, in the probe test, P38-treated group showed a specific interest for the target quadrant whereas the two other groups exhibited less focused place searching behavior. Moreover, P38 had an anxiogenic effect as measured by the distribution of swimming at the periphery of the pool. The swimming test resulted in a decrease in BDNF contents in the hippocampus. P38 but not P38-alg treatment restored BDNF expression. In terms of oxidative stress, both P38 and P38-alg treatments had antioxidative effects. The activity of antioxidative enzymes in the neocortex was increased. However only P38 reduced the levels of carbonylated proteins (CP). These data show that P38 and P38-alg have different behavioral and neurobiological effects. Thus, P38-alg and other analogs with specific functional profiles, inducing beneficial central effects (e.g. neuroprotection) while minimizing undesired peripheral effects may be useful for potential therapeutical use." @default.
- W2896829480 created "2018-10-26" @default.
- W2896829480 creator A5003657445 @default.
- W2896829480 creator A5003826134 @default.
- W2896829480 creator A5012791707 @default.
- W2896829480 creator A5023381438 @default.
- W2896829480 creator A5030108506 @default.
- W2896829480 creator A5034970275 @default.
- W2896829480 creator A5035893939 @default.
- W2896829480 creator A5045924226 @default.
- W2896829480 creator A5051446559 @default.
- W2896829480 creator A5056690448 @default.
- W2896829480 creator A5064939711 @default.
- W2896829480 date "2019-02-01" @default.
- W2896829480 modified "2023-09-26" @default.
- W2896829480 title "Comparison of the effects of PACAP-38 and its analog, acetyl-[Ala15, Ala20] PACAP-38-propylamide, on spatial memory, post-learning BDNF expression and oxidative stress in rat" @default.
- W2896829480 cites W1165140024 @default.
- W2896829480 cites W1194913466 @default.
- W2896829480 cites W1486293218 @default.
- W2896829480 cites W1490818157 @default.
- W2896829480 cites W1561552242 @default.
- W2896829480 cites W1567614586 @default.
- W2896829480 cites W1625944144 @default.
- W2896829480 cites W1750690213 @default.
- W2896829480 cites W1775749144 @default.
- W2896829480 cites W191793640 @default.
- W2896829480 cites W1927704523 @default.
- W2896829480 cites W1966175026 @default.
- W2896829480 cites W1966818151 @default.
- W2896829480 cites W1966935284 @default.
- W2896829480 cites W1969778772 @default.
- W2896829480 cites W1970516662 @default.
- W2896829480 cites W1973298176 @default.
- W2896829480 cites W1973349296 @default.
- W2896829480 cites W1973432238 @default.
- W2896829480 cites W1973800582 @default.
- W2896829480 cites W1973872423 @default.
- W2896829480 cites W1975765156 @default.
- W2896829480 cites W1976373179 @default.
- W2896829480 cites W1981036529 @default.
- W2896829480 cites W1981423842 @default.
- W2896829480 cites W1990095749 @default.
- W2896829480 cites W1990802251 @default.
- W2896829480 cites W1992309025 @default.
- W2896829480 cites W1996694544 @default.
- W2896829480 cites W1998391893 @default.
- W2896829480 cites W2000572114 @default.
- W2896829480 cites W2000954136 @default.
- W2896829480 cites W2002171978 @default.
- W2896829480 cites W2011801069 @default.
- W2896829480 cites W2017169966 @default.
- W2896829480 cites W2017257616 @default.
- W2896829480 cites W2018306273 @default.
- W2896829480 cites W2018869671 @default.
- W2896829480 cites W2021875927 @default.
- W2896829480 cites W2022206129 @default.
- W2896829480 cites W2024261023 @default.
- W2896829480 cites W2024875325 @default.
- W2896829480 cites W2024987339 @default.
- W2896829480 cites W2028563627 @default.
- W2896829480 cites W2033847645 @default.
- W2896829480 cites W2034117619 @default.
- W2896829480 cites W2038400818 @default.
- W2896829480 cites W2040585119 @default.
- W2896829480 cites W2041624508 @default.
- W2896829480 cites W2042445968 @default.
- W2896829480 cites W2044098851 @default.
- W2896829480 cites W2044669233 @default.
- W2896829480 cites W2046858058 @default.
- W2896829480 cites W2052950889 @default.
- W2896829480 cites W2064384267 @default.
- W2896829480 cites W2066954773 @default.
- W2896829480 cites W2067884489 @default.
- W2896829480 cites W2069316602 @default.
- W2896829480 cites W2071200462 @default.
- W2896829480 cites W2072836118 @default.
- W2896829480 cites W2073831388 @default.
- W2896829480 cites W2075927503 @default.
- W2896829480 cites W2076938752 @default.
- W2896829480 cites W2077615989 @default.
- W2896829480 cites W2088866343 @default.
- W2896829480 cites W2089822614 @default.
- W2896829480 cites W2090476662 @default.
- W2896829480 cites W2091854576 @default.
- W2896829480 cites W2098511020 @default.
- W2896829480 cites W2105533498 @default.
- W2896829480 cites W2135148203 @default.
- W2896829480 cites W2137495023 @default.
- W2896829480 cites W2138472216 @default.
- W2896829480 cites W2142766154 @default.
- W2896829480 cites W2149315740 @default.
- W2896829480 cites W2153880751 @default.
- W2896829480 cites W2154723142 @default.
- W2896829480 cites W2155166279 @default.
- W2896829480 cites W2156979070 @default.
- W2896829480 cites W2169222199 @default.
- W2896829480 cites W2279096042 @default.
- W2896829480 cites W2299908460 @default.