Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896835856> ?p ?o ?g. }
- W2896835856 endingPage "38" @default.
- W2896835856 startingPage "31" @default.
- W2896835856 abstract "Background MicroRNA-27a (miR-27a) is a small non-coding RNA, shown to play a role in multiple cancers, including the regulation of ERα expression in breast cancer. Most ERα positive tumors are treated with Selective Estrogen Receptor Modulators (SERMs) and thus the role of miR-27a expression in response to SERM treatment is of interest. Methods Tamoxifen resistant cells were generated by molecular evolution with six cycles of tamoxifen treatment. MCF7 and T47D luminal A breast cancer cell lines were either treated with miR-27a mimics, or ER-signaling was modulated ectopically. The changes were analyzed with RT-qPCR, western blotting and transcriptional activity ERE-reporter assays. Moreover, the response to SERM treatments (tamoxifen, endoxifen and toremifen) was investigated by cell viability and apoptosis measurements. An in silico analysis of survival data from the METABRIC study was performed in order to assess the prognostic value of miR-27a for response to SERM treatment. Results Tamoxifen-resistant cells showed decreased expression of ERα and miR-27a. The overexpression of miR-27a increased the levels of ERα, while modulation of ERα decreased miR-27a expression. High miR-27a expression increased the sensitivity of MCF7 and T47D cells to SERM treatments and re-sensitized the cells to tamoxifen. Patient survival of luminal A breast cancer patients that underwent endocrine therapies was better in groups with high miR-27a expression. Conclusion MiR-27a sensitizes luminal A breast cancer cells to SERM treatments based on a positive feedback loop with ERα. An increased overall-survival of ER-positive breast cancer patients that underwent endocrine treatments and displayed high miR-27a levels was found." @default.
- W2896835856 created "2018-10-26" @default.
- W2896835856 creator A5035820068 @default.
- W2896835856 creator A5041009612 @default.
- W2896835856 creator A5053207916 @default.
- W2896835856 creator A5053929487 @default.
- W2896835856 creator A5054660341 @default.
- W2896835856 date "2019-02-01" @default.
- W2896835856 modified "2023-10-12" @default.
- W2896835856 title "MiRNA-27a sensitizes breast cancer cells to treatment with Selective Estrogen Receptor Modulators" @default.
- W2896835856 cites W1757407923 @default.
- W2896835856 cites W1968745254 @default.
- W2896835856 cites W1971861967 @default.
- W2896835856 cites W1998242092 @default.
- W2896835856 cites W2005895632 @default.
- W2896835856 cites W2011910635 @default.
- W2896835856 cites W2015473392 @default.
- W2896835856 cites W2026467905 @default.
- W2896835856 cites W2026808108 @default.
- W2896835856 cites W2031113361 @default.
- W2896835856 cites W2082326948 @default.
- W2896835856 cites W2089516972 @default.
- W2896835856 cites W2105612107 @default.
- W2896835856 cites W2111442859 @default.
- W2896835856 cites W2114637992 @default.
- W2896835856 cites W2118728607 @default.
- W2896835856 cites W2120878888 @default.
- W2896835856 cites W2121071871 @default.
- W2896835856 cites W2128605357 @default.
- W2896835856 cites W2131199058 @default.
- W2896835856 cites W2131603976 @default.
- W2896835856 cites W2134092271 @default.
- W2896835856 cites W2161977537 @default.
- W2896835856 cites W2165192246 @default.
- W2896835856 cites W2215546485 @default.
- W2896835856 cites W2279779120 @default.
- W2896835856 cites W2286629281 @default.
- W2896835856 cites W2467745789 @default.
- W2896835856 cites W2531294657 @default.
- W2896835856 cites W2597734728 @default.
- W2896835856 cites W2605448241 @default.
- W2896835856 cites W2626249377 @default.
- W2896835856 cites W2739714794 @default.
- W2896835856 cites W2745767490 @default.
- W2896835856 cites W2753109313 @default.
- W2896835856 cites W2789864443 @default.
- W2896835856 cites W4229773606 @default.
- W2896835856 cites W4252714226 @default.
- W2896835856 doi "https://doi.org/10.1016/j.breast.2018.10.007" @default.
- W2896835856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30415143" @default.
- W2896835856 hasPublicationYear "2019" @default.
- W2896835856 type Work @default.
- W2896835856 sameAs 2896835856 @default.
- W2896835856 citedByCount "23" @default.
- W2896835856 countsByYear W28968358562019 @default.
- W2896835856 countsByYear W28968358562020 @default.
- W2896835856 countsByYear W28968358562021 @default.
- W2896835856 countsByYear W28968358562022 @default.
- W2896835856 countsByYear W28968358562023 @default.
- W2896835856 crossrefType "journal-article" @default.
- W2896835856 hasAuthorship W2896835856A5035820068 @default.
- W2896835856 hasAuthorship W2896835856A5041009612 @default.
- W2896835856 hasAuthorship W2896835856A5053207916 @default.
- W2896835856 hasAuthorship W2896835856A5053929487 @default.
- W2896835856 hasAuthorship W2896835856A5054660341 @default.
- W2896835856 hasConcept C104317684 @default.
- W2896835856 hasConcept C121608353 @default.
- W2896835856 hasConcept C126322002 @default.
- W2896835856 hasConcept C143998085 @default.
- W2896835856 hasConcept C145059251 @default.
- W2896835856 hasConcept C172313692 @default.
- W2896835856 hasConcept C2777164284 @default.
- W2896835856 hasConcept C2777176818 @default.
- W2896835856 hasConcept C2777944059 @default.
- W2896835856 hasConcept C502942594 @default.
- W2896835856 hasConcept C530470458 @default.
- W2896835856 hasConcept C55493867 @default.
- W2896835856 hasConcept C71924100 @default.
- W2896835856 hasConcept C84606932 @default.
- W2896835856 hasConcept C86803240 @default.
- W2896835856 hasConceptScore W2896835856C104317684 @default.
- W2896835856 hasConceptScore W2896835856C121608353 @default.
- W2896835856 hasConceptScore W2896835856C126322002 @default.
- W2896835856 hasConceptScore W2896835856C143998085 @default.
- W2896835856 hasConceptScore W2896835856C145059251 @default.
- W2896835856 hasConceptScore W2896835856C172313692 @default.
- W2896835856 hasConceptScore W2896835856C2777164284 @default.
- W2896835856 hasConceptScore W2896835856C2777176818 @default.
- W2896835856 hasConceptScore W2896835856C2777944059 @default.
- W2896835856 hasConceptScore W2896835856C502942594 @default.
- W2896835856 hasConceptScore W2896835856C530470458 @default.
- W2896835856 hasConceptScore W2896835856C55493867 @default.
- W2896835856 hasConceptScore W2896835856C71924100 @default.
- W2896835856 hasConceptScore W2896835856C84606932 @default.
- W2896835856 hasConceptScore W2896835856C86803240 @default.
- W2896835856 hasFunder F4320320879 @default.
- W2896835856 hasLocation W28968358561 @default.
- W2896835856 hasOpenAccess W2896835856 @default.