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• W2896835954 endingPage "1582" @default.
• W2896835954 startingPage "1575" @default.
• W2896835954 abstract "Similar to bacteria, yeast, and other organisms that have evolved pathways to respond to environmental stresses, cancer cells develop mechanisms that increase genetic diversity to facilitate adaptation to a variety of stressful conditions, including hypoxia, nutrient deprivation, exposure to DNA‐damaging agents, and immune responses. To survive, cancer cells trigger mechanisms that drive genomic instability and mutation, alter gene expression programs, and reprogram the metabolic pathways to evade growth inhibition signaling and immune surveillance. A deeper understanding of the molecular mechanisms that underlie the pathways used by cancer cells to overcome stresses will allow us to develop more efficacious strategies for cancer therapy. Herein, we overview several key stresses imposed on cancer cells, including oxidative, metabolic, mechanical, and genotoxic, and discuss the mechanisms that drive cancer cell responses. The therapeutic implications of these responses are also considered, as these factors pave the way for the targeting of stress adaption pathways in order to slow cancer progression and block resistance to therapy." @default.
• W2896835954 created "2018-10-26" @default.
• W2896835954 creator A5039896971 @default.
• W2896835954 creator A5072728610 @default.
• W2896835954 date "2018-10-12" @default.
• W2896835954 modified "2023-10-14" @default.
• W2896835954 title "Therapeutic targeting of cellular stress responses in cancer" @default.
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