Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896837916> ?p ?o ?g. }
- W2896837916 abstract "Chemotherapy is routinely used in cancer treatment to eliminate primary and metastatic tumor cells. However, tumors often display or develop resistance to chemotherapy. Mechanisms of chemoresistance can be either tumor cell autonomous or mediated by the tumor surrounding non-malignant cells, also known as stromal cells, which include fibroblasts, immune cells, and cells from the vasculature. Therapies targeting cancer cells have shown limited effectiveness in tumors characterized by a rich tumor stroma. Tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs) are the most abundant non-cancerous cells in the tumor stroma and have emerged as key players in cancer progression, metastasis and resistance to therapies. This review describes the recent advances in our understanding of how CAFs and TAMs confer chemoresistance to tumor cells and discusses the therapeutic opportunities of combining anti-tumor with anti-stromal therapies. The continued elucidation of the mechanisms by which TAMs and CAFs mediate resistance to therapies will allow the development of improved combination treatments for cancer patients." @default.
- W2896837916 created "2018-10-26" @default.
- W2896837916 creator A5024297597 @default.
- W2896837916 creator A5056987691 @default.
- W2896837916 date "2018-10-09" @default.
- W2896837916 modified "2023-10-14" @default.
- W2896837916 title "Macrophages and Fibroblasts, Key Players in Cancer Chemoresistance" @default.
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