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- W2896838340 abstract "Cerebral amyloid angiopathy (CAA) and hypertensive subcortical vascular cognitive impairments (hSVCI) have close associations with Alzheimer's disease (AD) neuropathologic change. However, the role and extent of amyloid beta (Aß) and neurofibrillary tangles (NFTs), which are hallmark of AD, have not been thoroughly investigated in CAA and hSVCI. Therefore, we investigated the characteristics of AD neuropathologic changes in CAA and hSVCI patients using Aβ and tau PET. We prospectively recruited 65 CAA patients and 195 hSVCI patients who underwent brain MRI and either PiB PET or Florbetaben (FBB) PET scans. Among them, 17 CAA and 51 hSVCI patients underwent AV1451 PET for tau imaging. Normal control (NC) group was included for comparison: 213 NC for FBB PET, and 19 NC for AV1451 PET comparison. We first compared Aβ PET positivity between groups; Aβ PET was defined to be positive when global SUVR was over the cutoff value of 1.5 for PiB PET or visual assessment of FBB PET was scored as 2 or 3 on the brain Aß plaque load scoring system. Then, we used the analysis of covariance model with age as covariates for voxel-based comparisons of FBB and AV1451 uptake in SPM8 between groups. hSVCI had a higher Aβ positivity (Aß (+)) than NC (30.3 vs. 11.7%, p<0.001), but a lower Aβ positivity than CAA (66.2 vs. 30.3%, p<0.001). Aß (+) hSVCI showed higher Aβ uptakes in diffuse cortical regions than NC, while it showed less Aβ uptakes especially in frontal regions than Aß (+) CAA. Similarly, hSVCI group had higher tau uptake than NC, while less tau uptake than CAA. (Figure 2)" @default.
- W2896838340 created "2018-10-26" @default.
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- W2896838340 date "2018-07-01" @default.
- W2896838340 modified "2023-10-16" @default.
- W2896838340 title "P1‐382: COMPARISON OF AD PATHOLOGIES IN HYPERTENSIVE SUBCORTICAL VASCULAR COGNITIVE IMPAIRMENT AND CEREBRAL AMYLOID ANGIOPATHY" @default.
- W2896838340 doi "https://doi.org/10.1016/j.jalz.2018.06.390" @default.
- W2896838340 hasPublicationYear "2018" @default.
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