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- W2896839095 abstract "The adoptive transfer of genetically engineered T cells modified to express a chimeric antigen receptor (CAR) has shown remarkable activity and induces long-term remissions in patients with advanced hematologic malignancies. To date, little is known about predictive indicators of therapeutic efficacy or serious toxicity after CAR T-cell therapy in clinical practice. Biomarkers are not only potentially able to inform physicians and researchers of immunotherapy targets in particular but could also be used to monitor the effectiveness of treatments and to predict incidence of side effects in some circumstances. Identification of new biomarkers can therefore not only contribute to the development of new therapeutic and prognostic strategies for CAR T-cell therapy for cancer but also help to generate improved clinical practices for early recognition and minimization of adverse effects while preserving the antitumor activity of the CAR T cells. Herein, we will consider a variety of predictive and therapeutic biomarkers in CAR T-cell therapy and the state of current understanding of their clinical utility. The incorporation of biomarker studies in CAR T-cell clinical trials and practice will help to realize the potential clinical benefit of biomarker-guided therapy." @default.
- W2896839095 created "2018-10-26" @default.
- W2896839095 creator A5014784394 @default.
- W2896839095 creator A5037938194 @default.
- W2896839095 creator A5043036338 @default.
- W2896839095 creator A5058516379 @default.
- W2896839095 creator A5059447343 @default.
- W2896839095 creator A5086024383 @default.
- W2896839095 date "2018-10-14" @default.
- W2896839095 modified "2023-10-03" @default.
- W2896839095 title "Predictive and therapeutic biomarkers in chimeric antigen receptor T‐cell therapy: A clinical perspective" @default.
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