FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896841699> ?p ?o ?g. }

• W2896841699 endingPage "1431" @default.
• W2896841699 startingPage "1410" @default.
• W2896841699 abstract "Argonaute2 (AGO2) is an effector of small RNA mediated gene silencing. Increasing evidence show that post-translational modifications of AGO2 can change miRNA activity at specific or global levels. Among the six mature miRNAs that are encoded by miR-17-92, miR-19b1 is the most powerful to exert the oncogenic properties of the entire cluster. Here we identify that AGO2 can be acetylated by P300/CBP and deacetylated by HDAC7, and that acetylation occurs at three sites K720, K493, and K355. Mutation of K493R/K720R, but not K355R at AGO2, inhibits miR-19b biogenesis. We demonstrate that acetylation of AGO2 specifically increases its recruiting pre-miR-19b1 to form the miPDC (miRNA precursor deposit complex), thereby to enhance miR-19b maturation. The motif UGUGUG in the terminal-loop of pre-miR-19b1, as a specific processing feature that is recognized and bound by acetylated AGO2, is essential for the assembly of miRISC (miRNA-induced silencing complex) loading complex. Analyses on public clinical data, xenograft mouse models, and IHC and ISH staining of lung cancer tissues, further confirm that the high levels of both AGO2 acetylation and miR-19b correlate with poor prognosis in lung cancer patients. Our finding reveals a novel function of AGO2 acetylation in increasing oncogenic miR-19b biogenesis and suggests that modulation of AGO2 acetylation has potential clinical implications." @default.
• W2896841699 created "2018-10-26" @default.
• W2896841699 creator A5000323703 @default.
• W2896841699 creator A5005070709 @default.
• W2896841699 creator A5007078745 @default.
• W2896841699 creator A5025321904 @default.
• W2896841699 creator A5029084419 @default.
• W2896841699 creator A5034110965 @default.
• W2896841699 creator A5036909733 @default.
• W2896841699 creator A5041146217 @default.
• W2896841699 creator A5059431543 @default.
• W2896841699 creator A5060389151 @default.
• W2896841699 creator A5062082438 @default.
• W2896841699 creator A5075470782 @default.
• W2896841699 creator A5088875686 @default.
• W2896841699 date "2018-10-10" @default.
• W2896841699 modified "2023-10-11" @default.
• W2896841699 title "Acetylation of AGO2 promotes cancer progression by increasing oncogenic miR-19b biogenesis" @default.
• W2896841699 cites W1626423022 @default.
• W2896841699 cites W1968525732 @default.
• W2896841699 cites W1969003435 @default.
• W2896841699 cites W1969367712 @default.
• W2896841699 cites W1975464080 @default.
• W2896841699 cites W1982250275 @default.
• W2896841699 cites W1989015932 @default.
• W2896841699 cites W1998770186 @default.
• W2896841699 cites W2003018477 @default.
• W2896841699 cites W2021364151 @default.
• W2896841699 cites W2023121881 @default.
• W2896841699 cites W2025013855 @default.
• W2896841699 cites W2046338307 @default.
• W2896841699 cites W2048378800 @default.
• W2896841699 cites W2049836150 @default.
• W2896841699 cites W2051555720 @default.
• W2896841699 cites W2054109341 @default.
• W2896841699 cites W2060666846 @default.
• W2896841699 cites W2062290101 @default.
• W2896841699 cites W2064792413 @default.
• W2896841699 cites W2066035587 @default.
• W2896841699 cites W2071596792 @default.
• W2896841699 cites W2078986358 @default.
• W2896841699 cites W2082213106 @default.
• W2896841699 cites W2085592081 @default.
• W2896841699 cites W2086227770 @default.
• W2896841699 cites W2090285371 @default.
• W2896841699 cites W2101543035 @default.
• W2896841699 cites W2102440372 @default.
• W2896841699 cites W2105549148 @default.
• W2896841699 cites W2116365126 @default.
• W2896841699 cites W2130979840 @default.
• W2896841699 cites W2135837360 @default.
• W2896841699 cites W2137084098 @default.
• W2896841699 cites W2139115320 @default.
• W2896841699 cites W2145484344 @default.
• W2896841699 cites W2146308072 @default.
• W2896841699 cites W2154841861 @default.
• W2896841699 cites W2156629568 @default.
• W2896841699 cites W2161222316 @default.
• W2896841699 cites W2161751301 @default.
• W2896841699 cites W2162328257 @default.
• W2896841699 cites W2162599367 @default.
• W2896841699 cites W2163868691 @default.
• W2896841699 cites W2165804743 @default.
• W2896841699 cites W2167430092 @default.
• W2896841699 cites W2168239981 @default.
• W2896841699 cites W2169465106 @default.
• W2896841699 cites W2238354465 @default.
• W2896841699 cites W2336797911 @default.
• W2896841699 cites W2342147827 @default.
• W2896841699 cites W2550327713 @default.
• W2896841699 cites W2552543114 @default.
• W2896841699 cites W2583057870 @default.
• W2896841699 cites W2606863448 @default.
• W2896841699 cites W2647027503 @default.
• W2896841699 cites W2732184391 @default.
• W2896841699 doi "https://doi.org/10.1038/s41388-018-0530-7" @default.
• W2896841699 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6372475" @default.
• W2896841699 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30305728" @default.
• W2896841699 hasPublicationYear "2018" @default.
• W2896841699 type Work @default.
• W2896841699 sameAs 2896841699 @default.
• W2896841699 citedByCount "50" @default.
• W2896841699 countsByYear W28968416992019 @default.
• W2896841699 countsByYear W28968416992020 @default.
• W2896841699 countsByYear W28968416992021 @default.
• W2896841699 countsByYear W28968416992022 @default.
• W2896841699 countsByYear W28968416992023 @default.
• W2896841699 crossrefType "journal-article" @default.
• W2896841699 hasAuthorship W2896841699A5000323703 @default.
• W2896841699 hasAuthorship W2896841699A5005070709 @default.
• W2896841699 hasAuthorship W2896841699A5007078745 @default.
• W2896841699 hasAuthorship W2896841699A5025321904 @default.
• W2896841699 hasAuthorship W2896841699A5029084419 @default.
• W2896841699 hasAuthorship W2896841699A5034110965 @default.
• W2896841699 hasAuthorship W2896841699A5036909733 @default.
• W2896841699 hasAuthorship W2896841699A5041146217 @default.
• W2896841699 hasAuthorship W2896841699A5059431543 @default.
• W2896841699 hasAuthorship W2896841699A5060389151 @default.

• next