Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896849380> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2896849380 abstract "Most neurodegenerative disorders, such as Alzheimer's disease (AD) or Parkinson's disease (PD), are chronic, not only is the clinical course after the onset but is also the prodromal neurodegenerative process, which is believed to take decades. This is true in the relevant animal models as well, in which synaptic/dendritic degeneration and behavioral deficits occur long before significant neuronal loss is evident. Therefore, it appears that central nervous system (CNS) neurons can afford to lose their distal terminals without triggering the neuronal death. This is almost like trees losing their leaves in the winter, which is a survival strategy and deemed to fully replenish in the spring. Our question is that given the decade-long time window of having these many “winterized” neurons, would it be possible to revitalize these degenerating CNS neurons before they head to their destination of death? To explore such a possibility that the “winterized” degenerating CNS neurons can stop the degenerative process and regenerate their neurites, we employed single neuron culture technique and observed primary hippocampal neurons for their spontaneous degenerative process and regenerative activities, if any. We found that 42.3% of the primary hippocampal neurons (PHN) underwent rapid necrotic dell death whereas 57.7% PHN underwent a chronic neurodegeneration resembling the “dying-back” process. Although the durations varied among different neurons, there was a clearly identifiable time window between the initial distal neurite fragmentation and the eventual lysis of the cell body. Surprisingly, we found that a few hippocampal neurons can lose their neurites up to 92% without triggering the cell death; moreover, they fully regrow their neurites just like a winterized tree revitalizing in the spring. This observation implicates that, given the right conditions, the “winterized” degenerating CNS neurons in AD or PD possess the ability to fully regenerate and revitalize that may offer a great therapeutic opportunity even more realistic than stem cell transplantation." @default.
- W2896849380 created "2018-10-26" @default.
- W2896849380 creator A5032902120 @default.
- W2896849380 creator A5039837606 @default.
- W2896849380 creator A5040540478 @default.
- W2896849380 creator A5070208373 @default.
- W2896849380 date "2018-07-01" @default.
- W2896849380 modified "2023-10-02" @default.
- W2896849380 title "P4‐187: AN ALTERNATIVE FATE OF DEGENERATIVE HIPPOCAMPAL NEURONS" @default.
- W2896849380 doi "https://doi.org/10.1016/j.jalz.2018.06.2592" @default.
- W2896849380 hasPublicationYear "2018" @default.
- W2896849380 type Work @default.
- W2896849380 sameAs 2896849380 @default.
- W2896849380 citedByCount "0" @default.
- W2896849380 crossrefType "journal-article" @default.
- W2896849380 hasAuthorship W2896849380A5032902120 @default.
- W2896849380 hasAuthorship W2896849380A5039837606 @default.
- W2896849380 hasAuthorship W2896849380A5040540478 @default.
- W2896849380 hasAuthorship W2896849380A5070208373 @default.
- W2896849380 hasConcept C113246987 @default.
- W2896849380 hasConcept C142724271 @default.
- W2896849380 hasConcept C148762608 @default.
- W2896849380 hasConcept C169760540 @default.
- W2896849380 hasConcept C190283241 @default.
- W2896849380 hasConcept C202751555 @default.
- W2896849380 hasConcept C2776925932 @default.
- W2896849380 hasConcept C2778794669 @default.
- W2896849380 hasConcept C2779134260 @default.
- W2896849380 hasConcept C2779354088 @default.
- W2896849380 hasConcept C2781161787 @default.
- W2896849380 hasConcept C31573885 @default.
- W2896849380 hasConcept C55493867 @default.
- W2896849380 hasConcept C71924100 @default.
- W2896849380 hasConcept C86803240 @default.
- W2896849380 hasConceptScore W2896849380C113246987 @default.
- W2896849380 hasConceptScore W2896849380C142724271 @default.
- W2896849380 hasConceptScore W2896849380C148762608 @default.
- W2896849380 hasConceptScore W2896849380C169760540 @default.
- W2896849380 hasConceptScore W2896849380C190283241 @default.
- W2896849380 hasConceptScore W2896849380C202751555 @default.
- W2896849380 hasConceptScore W2896849380C2776925932 @default.
- W2896849380 hasConceptScore W2896849380C2778794669 @default.
- W2896849380 hasConceptScore W2896849380C2779134260 @default.
- W2896849380 hasConceptScore W2896849380C2779354088 @default.
- W2896849380 hasConceptScore W2896849380C2781161787 @default.
- W2896849380 hasConceptScore W2896849380C31573885 @default.
- W2896849380 hasConceptScore W2896849380C55493867 @default.
- W2896849380 hasConceptScore W2896849380C71924100 @default.
- W2896849380 hasConceptScore W2896849380C86803240 @default.
- W2896849380 hasIssue "7S_Part_29" @default.
- W2896849380 hasLocation W28968493801 @default.
- W2896849380 hasOpenAccess W2896849380 @default.
- W2896849380 hasPrimaryLocation W28968493801 @default.
- W2896849380 hasRelatedWork W1501306774 @default.
- W2896849380 hasRelatedWork W1997281208 @default.
- W2896849380 hasRelatedWork W2010108080 @default.
- W2896849380 hasRelatedWork W2101607104 @default.
- W2896849380 hasRelatedWork W2138730144 @default.
- W2896849380 hasRelatedWork W2783633930 @default.
- W2896849380 hasRelatedWork W2980640576 @default.
- W2896849380 hasRelatedWork W3033872672 @default.
- W2896849380 hasRelatedWork W4317939744 @default.
- W2896849380 hasRelatedWork W82234544 @default.
- W2896849380 hasVolume "14" @default.
- W2896849380 isParatext "false" @default.
- W2896849380 isRetracted "false" @default.
- W2896849380 magId "2896849380" @default.
- W2896849380 workType "article" @default.