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- W2896852757 abstract "The first catalytic enantioselective aldol reaction of various unprotected carboxylic acids is described. In the presence of a chiral bis(phosphine oxide) as a Lewis base catalyst, carboxylic acids were activated with silicon tetrachloride to form the corresponding bis(trichlorosilyl)enediolates in situ, which subsequently underwent an aldol reaction with an aldehyde or a ketone to produce β-hydroxycarboxylic acids in high enantioselectivities of up to 92 % ee." @default.
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- W2896852757 date "2018-11-05" @default.
- W2896852757 modified "2023-10-14" @default.
- W2896852757 title "Catalytic Enantioselective Aldol Reactions of Unprotected Carboxylic Acids under Phosphine Oxide Catalysis" @default.
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- W2896852757 doi "https://doi.org/10.1002/anie.201810599" @default.
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