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- W2896853498 abstract "Different terminals of the sensorimotor network show varied somatotopic arrangements of body-part representations. Since somatotopy is best characterized in the primary somatosensory (S1) and motor (M1) cortices, these terminals have been the main target for research on somatotopic alterations following loss of sensory input (e.g. arm amputation). Such reorganization is generally considered to be driven by the spatial layout of the underlying somatotopy, such that neighboring body-part representations tend to occupy the deprived brain region. For example, following arm deafferentation in non-human primates, the S1 deprived hand area becomes responsive to inputs from the chin, which has a native representation that cortically neighbors that of the (now deprived) hand region. Here we challenge the assumption of proximity-based reorganization, by comparing patterns of reorganization in people born without one hand (hereafter, one-handers, n=26, 15 female) in the cerebellum and the primary sensorimotor cortex. We first report that in the cerebellum of one-handers, the deprived hand region represents multiple body-parts, despite varying distances between the native representations of these body-parts and the deprived hand region. We further replicate our previous finding, showing a similar pattern of reorganization in the deprived hand region of the cerebral cortex in one-handers. Since the cerebellar and cerebral cortices contain different somatotopic layouts, the parallel reorganization observed in these two terminals demonstrates that the mere spatial layout of body-part representations may not exclusively dictate reorganization in the sensorimotor network. Instead, we discuss alternative drivers of reorganization, and particularly, the possible role of adaptive behavior and sub-cortical plasticity." @default.
- W2896853498 created "2018-10-26" @default.
- W2896853498 creator A5057131793 @default.
- W2896853498 creator A5065801137 @default.
- W2896853498 date "2018-10-09" @default.
- W2896853498 modified "2023-09-23" @default.
- W2896853498 title "Reorganization in cerebral and cerebellar cortices is not restricted by proximity between body-part representations" @default.
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