Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896856307> ?p ?o ?g. }
- W2896856307 endingPage "256" @default.
- W2896856307 startingPage "245" @default.
- W2896856307 abstract "Background: Cancer metastasis has emerged as a major public health threat that causes majority of cancer fatalities. Traditional chemotherapeutics have been effective in the past but suffer from low therapeutic efficiency and harmful side-effects. Recently, it has been reported ursolic acid (UA), one of the naturally abundant pentacyclic triterpenes, possesses a wide range of biological activities including anti-inflammatory, anti-atherosclerotic, and anti-cancer properties. More importantly, UA has the features of low toxicity, liver protection and the potential of anti-cancer metastasis. Objective: This article aimed at reviewing the great potential of UA used as a candidate drug in the field of cancer therapy relating to suppression of tumor initiation, progression and metastasis. Methods: Selective searches were conducted in Pubmed, Google Scholar and Web of Science using the keywords and subheadings from database inception to December 2017. Systemic reviews are summarized here. Results: UA has exhibited chemopreventive and therapeutic effects of cancer mainly through inducing apoptosis, inhibiting cell proliferation, preventing tumor angiogenesis and metastatic. UA nanoformulations could enhance the solubility and bioavailability of UA as well as exhibit better inhibitory effect on tumor growth and metastasis. Conclusion: The information presented in this article can provide useful references for further studies on making UA a promising anti-cancer drug, especially as a prophylactic metastatic agent for clinical applications." @default.
- W2896856307 created "2018-10-26" @default.
- W2896856307 creator A5003753200 @default.
- W2896856307 creator A5031927530 @default.
- W2896856307 creator A5036486877 @default.
- W2896856307 creator A5038682568 @default.
- W2896856307 creator A5064455541 @default.
- W2896856307 creator A5085920690 @default.
- W2896856307 date "2019-03-21" @default.
- W2896856307 modified "2023-10-18" @default.
- W2896856307 title "Ursolic Acid in Cancer Treatment and Metastatic Chemoprevention: From Synthesized Derivatives to Nanoformulations in Preclinical Studies" @default.
- W2896856307 cites W1072449031 @default.
- W2896856307 cites W1773149959 @default.
- W2896856307 cites W1835542131 @default.
- W2896856307 cites W1913371122 @default.
- W2896856307 cites W1927915280 @default.
- W2896856307 cites W1951344334 @default.
- W2896856307 cites W1964698686 @default.
- W2896856307 cites W1965255713 @default.
- W2896856307 cites W1965611547 @default.
- W2896856307 cites W1966748944 @default.
- W2896856307 cites W1967334719 @default.
- W2896856307 cites W1968659809 @default.
- W2896856307 cites W1976442101 @default.
- W2896856307 cites W1976605228 @default.
- W2896856307 cites W1976748056 @default.
- W2896856307 cites W1977352545 @default.
- W2896856307 cites W1977891655 @default.
- W2896856307 cites W1978870744 @default.
- W2896856307 cites W1981717147 @default.
- W2896856307 cites W1981815345 @default.
- W2896856307 cites W1981989535 @default.
- W2896856307 cites W1985374049 @default.
- W2896856307 cites W1986352249 @default.
- W2896856307 cites W1988193392 @default.
- W2896856307 cites W1988541612 @default.
- W2896856307 cites W1993615070 @default.
- W2896856307 cites W1996023050 @default.
- W2896856307 cites W1996456516 @default.
- W2896856307 cites W2003265402 @default.
- W2896856307 cites W2003804164 @default.
- W2896856307 cites W2007237444 @default.
- W2896856307 cites W2013464322 @default.
- W2896856307 cites W2013816495 @default.
- W2896856307 cites W2014260136 @default.
- W2896856307 cites W2014342718 @default.
- W2896856307 cites W2017171454 @default.
- W2896856307 cites W2022607627 @default.
- W2896856307 cites W2024382973 @default.
- W2896856307 cites W2026703836 @default.
- W2896856307 cites W2030141189 @default.
- W2896856307 cites W2034269086 @default.
- W2896856307 cites W2038501684 @default.
- W2896856307 cites W2044765890 @default.
- W2896856307 cites W2046793969 @default.
- W2896856307 cites W2050273205 @default.
- W2896856307 cites W2051792874 @default.
- W2896856307 cites W2052126027 @default.
- W2896856307 cites W2056632213 @default.
- W2896856307 cites W2058635721 @default.
- W2896856307 cites W2063482106 @default.
- W2896856307 cites W2063822371 @default.
- W2896856307 cites W2064921662 @default.
- W2896856307 cites W2068405904 @default.
- W2896856307 cites W2069126054 @default.
- W2896856307 cites W2071890516 @default.
- W2896856307 cites W2071988200 @default.
- W2896856307 cites W2078029501 @default.
- W2896856307 cites W2084682984 @default.
- W2896856307 cites W2089506765 @default.
- W2896856307 cites W2089606905 @default.
- W2896856307 cites W2091085622 @default.
- W2896856307 cites W2091528268 @default.
- W2896856307 cites W2092874417 @default.
- W2896856307 cites W2093921289 @default.
- W2896856307 cites W2094644415 @default.
- W2896856307 cites W2109499935 @default.
- W2896856307 cites W2112394810 @default.
- W2896856307 cites W2115034438 @default.
- W2896856307 cites W2119642652 @default.
- W2896856307 cites W2121666713 @default.
- W2896856307 cites W2133479465 @default.
- W2896856307 cites W2148842714 @default.
- W2896856307 cites W2152083648 @default.
- W2896856307 cites W2153161557 @default.
- W2896856307 cites W2166103775 @default.
- W2896856307 cites W2274305540 @default.
- W2896856307 cites W2327362588 @default.
- W2896856307 cites W2334019335 @default.
- W2896856307 cites W2346645310 @default.
- W2896856307 cites W2403011436 @default.
- W2896856307 cites W2414284584 @default.
- W2896856307 cites W2479381614 @default.
- W2896856307 cites W2479610589 @default.
- W2896856307 cites W2488647228 @default.
- W2896856307 cites W2520530175 @default.
- W2896856307 cites W2522678042 @default.
- W2896856307 cites W2529449388 @default.