FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896862709> ?p ?o ?g. }

• W2896862709 abstract "Baclofen, a GABA-B receptor agonist, is a promising treatment for alcohol use disorder (AUD). Its mechanism of action in this condition is unknown. GABA-B receptors interact with many biological systems potentially involved in AUD, including transduction pathways and neurotransmitter systems. Preclinical studies have shown that GABA-B receptors are involved in memory storage and retrieval, reward, motivation, mood and anxiety; neuroimaging studies in humans show that baclofen produces region-specific alterations in cerebral activity; GABA-B receptor activation may have neuroprotective effects; baclofen also has anti-inflammatory properties that may be of interest in the context of addiction. However, none of these biological effects fully explain the mechanism of action of baclofen in AUD. Data from clinical studies have provided a certain number of elements which may be useful for the comprehension of its mechanism of action: baclofen typically induces a state of indifference toward alcohol; the effective dose of baclofen in AUD is extremely variable from one patient to another; higher treatment doses correlate with the severity of the addiction; many of the side effects of baclofen resemble those of alcohol, raising the possibility that baclofen acts as a substitution drug; usually, however, there is no tolerance to the effects of baclofen during long-term AUD treatment. In the present article, the biological effects of baclofen are reviewed in the light of its clinical effects in AUD, assuming that, in many instances, clinical effects can be reliable indicators of underlying biological processes. In conclusion, it is proposed that baclofen may suppress the Pavlovian association between cues and rewards through an action in a critical part of the dopaminergic network (the amygdala), thereby normalizing the functional connectivity in the reward network. It is also proposed that this action of baclofen is made possible by the fact that baclofen and alcohol act on similar brain systems in certain regions of the brain." @default.
• W2896862709 created "2018-10-26" @default.
• W2896862709 creator A5060083444 @default.
• W2896862709 date "2018-10-17" @default.
• W2896862709 modified "2023-10-12" @default.
• W2896862709 title "A Review of the Potential Mechanisms of Action of Baclofen in Alcohol Use Disorder" @default.
• W2896862709 cites W1486909174 @default.
• W2896862709 cites W1528560625 @default.
• W2896862709 cites W1570477602 @default.
• W2896862709 cites W1586445468 @default.
• W2896862709 cites W1592627143 @default.
• W2896862709 cites W1752388475 @default.
• W2896862709 cites W1759494822 @default.
• W2896862709 cites W1966590399 @default.
• W2896862709 cites W1966817490 @default.
• W2896862709 cites W1967529451 @default.
• W2896862709 cites W1969307826 @default.
• W2896862709 cites W1972452575 @default.
• W2896862709 cites W1972562670 @default.
• W2896862709 cites W1973631822 @default.
• W2896862709 cites W1976531501 @default.
• W2896862709 cites W1978846422 @default.
• W2896862709 cites W1982707902 @default.
• W2896862709 cites W1984160372 @default.
• W2896862709 cites W1986060607 @default.
• W2896862709 cites W1986283937 @default.
• W2896862709 cites W1989583246 @default.
• W2896862709 cites W1997598304 @default.
• W2896862709 cites W1997956841 @default.
• W2896862709 cites W1998472642 @default.
• W2896862709 cites W2002166282 @default.
• W2896862709 cites W2003278415 @default.
• W2896862709 cites W2003711874 @default.
• W2896862709 cites W2003916405 @default.
• W2896862709 cites W2004439638 @default.
• W2896862709 cites W2005635370 @default.
• W2896862709 cites W2005871900 @default.
• W2896862709 cites W2007027293 @default.
• W2896862709 cites W2008145393 @default.
• W2896862709 cites W2009577585 @default.
• W2896862709 cites W2009655691 @default.
• W2896862709 cites W2010759238 @default.
• W2896862709 cites W2012668558 @default.
• W2896862709 cites W2013232872 @default.
• W2896862709 cites W2014157322 @default.
• W2896862709 cites W2015546490 @default.
• W2896862709 cites W2016449743 @default.
• W2896862709 cites W2017171790 @default.
• W2896862709 cites W2017934537 @default.
• W2896862709 cites W2020273146 @default.
• W2896862709 cites W2021782736 @default.
• W2896862709 cites W2022660578 @default.
• W2896862709 cites W2025426971 @default.
• W2896862709 cites W2025761725 @default.
• W2896862709 cites W2029785909 @default.
• W2896862709 cites W2029862519 @default.
• W2896862709 cites W2037809822 @default.
• W2896862709 cites W2039251119 @default.
• W2896862709 cites W2041479117 @default.
• W2896862709 cites W2045914053 @default.
• W2896862709 cites W2046558738 @default.
• W2896862709 cites W2047258662 @default.
• W2896862709 cites W2047688049 @default.
• W2896862709 cites W2057235410 @default.
• W2896862709 cites W2058704897 @default.
• W2896862709 cites W2060355804 @default.
• W2896862709 cites W2066991732 @default.
• W2896862709 cites W2070634445 @default.
• W2896862709 cites W2071815275 @default.
• W2896862709 cites W2074214484 @default.
• W2896862709 cites W2075114927 @default.
• W2896862709 cites W2076432816 @default.
• W2896862709 cites W2078594409 @default.
• W2896862709 cites W2078639824 @default.
• W2896862709 cites W2084236418 @default.
• W2896862709 cites W2084701534 @default.
• W2896862709 cites W2085083593 @default.
• W2896862709 cites W2086115335 @default.
• W2896862709 cites W2086679927 @default.
• W2896862709 cites W2088408732 @default.
• W2896862709 cites W2089140744 @default.
• W2896862709 cites W2089251912 @default.
• W2896862709 cites W2089429969 @default.
• W2896862709 cites W2091076275 @default.
• W2896862709 cites W2096877847 @default.
• W2896862709 cites W2101551081 @default.
• W2896862709 cites W2101997000 @default.
• W2896862709 cites W2103666430 @default.
• W2896862709 cites W2104305453 @default.
• W2896862709 cites W2104753186 @default.
• W2896862709 cites W2115147032 @default.
• W2896862709 cites W2121289963 @default.
• W2896862709 cites W2123575723 @default.
• W2896862709 cites W2125320089 @default.
• W2896862709 cites W2125995400 @default.
• W2896862709 cites W2127279273 @default.
• W2896862709 cites W2134259978 @default.
• W2896862709 cites W2136475835 @default.
• W2896862709 cites W2136824162 @default.
• W2896862709 cites W2136959259 @default.

• next