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- W2896865569 abstract "Background: Innate immune responses activated through myeloid cells contribute to the initiation, progression and complications of atherosclerosis in experimental models. However, the critical upstream pathways that link innate immune activation to foam cell formation are still poorly identified. We hypothesized that activation of TREM (Triggering Receptor Expressed on Myeloid cells)-1 plays a determinant role in macrophage atherogenic responses. Methods and Results: Ldlr-/- mice reconstituted with bone marrow deficient for Trem-1 (Trem-1-/-) showed a strong reduction of atherosclerotic plaque size in both the aortic sinus and the thoraco-abdominal aorta, and displayed a less inflammatory plaque phenotype compared to Trem-1+/+ chimeric mice. Genetic invalidation of Trem-1 led to alteration of monocyte recruitment into atherosclerotic lesions and inhibited Tlr4-initiated pro-inflammatory macrophage responses. Furthermore, we identified a critical role for Trem-1 in the upregulation of Cd36, thereby promoti..." @default.
- W2896865569 created "2018-10-26" @default.
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- W2896865569 date "2016-11-11" @default.
- W2896865569 modified "2023-09-23" @default.
- W2896865569 title "Abstract 18482: Genetic and Pharmacologic Inhibition of Trem-1 Limits the Development of Experimental Atherosclerosis" @default.
- W2896865569 hasPublicationYear "2016" @default.
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